Diffuse large B-cell lymphoma, not otherwise specified of the palate: a case report

Abstract

Diffuse large B-cell lymphoma (DLBCL) is the most frequent type of non-Hodgkin´s lymphoma found in oral and maxillofacial regions. A large number of cases may be biologically heterogeneous, which are commonly defined as DLBCL, not otherwise specified (NOS) by the World Health Organization (WHO-2008). The present case reports on an ulcer of raised and irregular edges, found on the border between the hard and soft palate, as the first and only manifestation of an extranodal non-Hodgkin lymphoma in an 85-year-old patient. Incisional biopsy was carried out, and the specimen revealed a proliferation of large lymphoid cells suggestive of diffuse large cell lymphoma. An immunohistochemical analysis was performed. EBV-RNA was assessed by in situ hybridization that also proved to be negative. Immunohistochemical and EBV analyses are important to avoid delays and inappropriate treatment strategies. Although advanced age is considered an adverse prognostic factor, early diagnosis did prove to be a key contributory factor in the cure of non-Hodgkin lymphoma. Key words:Diffuse large B-cell lymphoma, elderly, EBV.

Profile of usage of a reference diagnostic service on oral pathology: a 10-year evaluation

“…Instead, immunohistochemistry should be useful to confirm diagnostic hypothesis in some cases, helping to identify some rare or atypical benign lesions, or to characterize malignant tumors [ 8 ]. Both situations are exemplified in our service with diagnoses of lesions such as solitary fibrous tumor [ 9 ] and lymphomas [ 10 ] (Figure 4 ).…”

Oral Adenosquamous Carcinoma Mimicking a Pyogenic Granuloma: a Challenging Diagnosis

“…In the present case, the mass was lobulated and located centrally in hard palate. Due to the benign characteristics of the lesion and clinical history, malignant tumours were not considered as hypotheses, although some oral manifestations of malignant diseases, such as non-Hodgkin's lymphomas may occur in the palate, with unusual reports of subtype B (16)(17) even as nodular lesion (17).…”

Effects of viral proteins on the nuclear organization of human peripheral blood B-cells

“…Le lymphome diffus à grandes cellules B est classifié parmi les lymphomes agressifs et les plus fréquents. C'est une maladie hétérogène en terme de comportement clinique et biologique (pour revue (Schmidt-Hansen et al, 2017)), avec des caractéristiques moléculaires et pronostiques différentes, malgré le traitement uniforme des patients (Souto et al, 2013;Zhou et al, 2014b).…”

“…Cependant, un pourcentage significatif de DLBCL manque d'anomalies génétiques spécifiques (Souto et al, 2013;Vose, 1998). Les DLBCL présentant une surexpression de l'oncogène MYC, sont les plus agressifs et les plus résistants aux thérapies standards (Smith et al, 2010).…”