Diffuse Idiopathic Skeletal Hyperostosis Is Associated with Lower Lung Volumes in Current and Former Smokers

Oudkerk, Sytse F.; Buckens, Constantinus F.; Mali, Willem P.Th.M.; Koning, Harry J. de; Öner, F. Cumhur; Vliegenthart, Rozemarijn; Pompe, Esther; Lammers, Jan‐Willem J.; Hoesein, Firdaus A. A. Mohamed; Verlaan, Jorrit‐Jan; Jong, Pim A. de

doi:10.1164/rccm.201510-1971le

Cited by 12 publications

(6 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We showed that these subjects with DISH have a substantial higher burden of coronary artery disease compared to subjects without DISH, independent of age, gender and race. Although DISH was known to be associated with worse outcome in the setting of trauma, there is now growing evidence that DISH is associated with restrictive respiratory physiology [20] and with these findings is associated with coronary artery disease. This challenges the notion that the incidental finding of DISH on radiography or crosssectional imaging is a benign characteristic or event.…”

Section: Discussionmentioning

confidence: 99%

Subjects with diffuse idiopathic skeletal hyperostosis have an increased burden of coronary artery disease: An evaluation in the COPDGene cohort

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Subjects with diffuse idiopathic skeletal hyperostosis have an increased burden of coronary artery disease: An evaluation in the COPDGene cohort

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“… 1 , 2 If spinal ankylosis develops, clinical symptoms such as back pain, restricted range of motion, reduced vital capacity, dysphagia, and airway obstruction arise. 1 - 6 Vertebral body fracture can be caused by even minimal injury, with the risk of such fracture reported to be 2 to 5 times higher than in patients without ankylosis. 7 - 9 In cases of spinal fracture accompanied by DISH, the spine assumes the form of a long lever arm, resulting in concentration of stress at the fractured site.…”

Section: Introductionmentioning

confidence: 99%

Progression of Ossification of the Anterior Longitudinal Ligament Associated With Diffuse Idiopathic Skeletal Hyperostosis by Age: A Study of Computed Tomography Findings Over 5 Years

Murakami

Morino

Hino

et al. 2020

Global Spine Journal

View full text Add to dashboard Cite

Study Design: Observational study. Objective: To investigate whether the progression of anterior longitudinal ligament ossification varies by age among patients with diffuse idiopathic skeletal hyperostosis (DISH). Methods: Of the patients who underwent computed tomography (CT) of the thoracic to pelvic region at least twice from 2009 to 2018, 191 who underwent CT at an interval of 5 years and 0 months to 5 years and 2 months were enrolled (87 men and 104 women). Sex, age at the time of the first CT scan, the presence/absence of DISH, level of complete vertebral body fusion associated with DISH, and extent of ligament ossification using the modified Mata scoring system were investigated. Results: DISHs were detected in 53 (27.7%) of 191 patients. The score of ligament ossification increased over time in 35 (66%) of 53 patients; 93 intervertebral spaces were affected. The percentage of completely fused intervertebral spaces increased by 6.7% from 31.3% to 38.0% over time. The increase in score for all intervertebral spaces in individual patients was significantly greater in the ≤70 years old group (2.7 ± 2.8 points, n = 28) than in the ≥71 years old group (1.2 ± 1.4 points; n = 25; P = .028). The mean age of patients with a recorded score that increased by ≥1 point was 67.4 years and that of patients without any change in the score was 73.3 years ( P = .036). Thus, patients with recorded changes in the score were younger. Conclusion: During the approximately 5-year period, ossification progressed more in younger patients than in older patients.

show abstract

“…Moreover, signs of asthma, such as persistent coughing and wheezing sounds, were not observed. Based on a study reporting the association of DISH with reduced FEV 1 , 18) we speculate that DISH affected the patient's expiratory ability and vital capacity.…”

Section: Discussionmentioning

confidence: 88%

Two Cases of Severe Type 2 Respiratory Failure Associated with Diffuse Idiopathic Skeletal Hyperostosis

Sato

Bannai

Miyake

et al. 2021

Ann Geriatr Med Res

View full text Add to dashboard Cite

Diffuse idiopathic skeletal hyperostosis (DISH) is a non-inflammatory process characterized by hyperostosis at tendon insertions and around joint capsules and ossification of the anterior longitudinal ligament of the spine. The flexibility of the spinal column is reduced in DISH and affects the movement of the thorax, leading to restrictive ventilatory function. In this report, we describe the first two cases of severe type 2 (hypercapnic) respiratory failure associated with DISH. Two older men presented with histories of shortness of breath. Radiography of the spine revealed DISH with coexisting ankylosis of the costovertebral joints. The patients’ thoracic motion was severely restricted, reducing the mechanism of lung expansion to diaphragm contraction only. Both patients required non-invasive positive-pressure ventilation therapy to cope with their conditions. Our report sheds light on the risk of potentially life-threatening respiratory manifestations of DISH among older adults.

show abstract

Diffuse Idiopathic Skeletal Hyperostosis Is Associated with Lower Lung Volumes in Current and Former Smokers

Cited by 12 publications

References 8 publications

Subjects with diffuse idiopathic skeletal hyperostosis have an increased burden of coronary artery disease: An evaluation in the COPDGene cohort

Subjects with diffuse idiopathic skeletal hyperostosis have an increased burden of coronary artery disease: An evaluation in the COPDGene cohort

Progression of Ossification of the Anterior Longitudinal Ligament Associated With Diffuse Idiopathic Skeletal Hyperostosis by Age: A Study of Computed Tomography Findings Over 5 Years

Two Cases of Severe Type 2 Respiratory Failure Associated with Diffuse Idiopathic Skeletal Hyperostosis

Contact Info

Product

Resources

About