Diffuse correlation spectroscopy and tomography for longitudinal monitoring of blood flow changes induced by chemotherapy in breast cancer xenografts

Choe, Regine; Ramirez, Gabriel A.; Proctor, Ashley R.; Han, Songfeng; Durdurán, Turgut; Brown, Edward B.

doi:10.1364/cancer.2016.ctu4a.4

Cited by 1 publication

(1 citation statement)

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“…With the current methods, longitudinal blood flow changes during graft healing were successfully monitored non-invasively and the spatial and temporal differences among three graft types were revealed. The versatility of the current system also enables direct application in other studies, such as monitoring tumor blood flow change after chemotherapy in rats [65]. Despite the improvements, several limitations remain to be addressed in future studies.…”

Section: Development Of Methodsmentioning

confidence: 99%

Non-invasive diffuse correlation tomography reveals spatial and temporal blood flow differences in murine bone grafting approaches

Han

Proctor

Vella³

et al. 2016

Biomed. Opt. Express

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Longitudinal blood flow during murine bone graft healing was monitored non-invasively using diffuse correlation tomography. The system utilized spatially dense data from a scanning set-up, non-linear reconstruction, and micro-CT anatomical information. Weekly measurements were performed. Blood flow changes in autografts, which heal successfully, were localized to graft regions and consistent across mice. Poor healing allografts showed heterogeneous blood flow elevation and high inter-subject variabilities. Allografts with tissue-engineered periosteum showed responses intermediate to both autografts and allografts, consistent with healing observed. These findings suggest that spatiotemporal blood flow changes can be utilized to differentiate the degree of bone graft healing.

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Section: Development Of Methodsmentioning

confidence: 99%