Diffuse B cell lymphoma without lymphadenopathy accompanied by reactive histiocytosis simulating malignant histiocytosis: A report of three autopsy cases.

Saito, Chikara; Takagi, Toshiyuki; Oguro, M; Wakatsuki, Susumu; Aoi, Takeshi; Maruyama, Kohshi

doi:10.3960/jslrt1961.31.27

Cited by 3 publications

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“…Respiratory signs and symptoms such as dyspnoea, hypoxia and chest radiographs and/or CT abnormalities were described in three cases. Of these three cases, TBLB was performed in two; one was case 3 in our series and the other was reported by Sakai et al (1991). The latter case also should have been diagnosed as IVL based on the TBLB specimen.…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge in the literature, nine cases of MH-like BCL have been reported in Japan (Kuratsune et al, 1988;Sakai et al, 1991;Imai et al, 1992;Iwahashi et al, 1992;Takeshita et al, 1993;Yamada et al, 1996). Table III summarizes the clinicopathological features of the 14 cases reported as MH-like BCL, including our five cases.…”

Section: Discussionmentioning

confidence: 99%

“…However, autopsies of two cases revealed histopathologic findings which were characteristic of IVL. Based on these observations, careful investigation of the other three cases of the present series and the nine cases previously described as MH-like BCL in the Japanese literature (Kuratsune et al, 1988;Sakai et al, 1991;Imai et al, 1992;Iwahashi et al, 1992;Takeshita et al, 1993;Yamada et al, 1996) suggests that most of them might fall within the framework of IVL and form a distinct variant.…”

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confidence: 99%

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Malignant histiocytosis‐like B‐cell lymphoma, a distinct pathologic variant of intravascular lymphomatosis: a report of five cases and review of the literature

Murase¹,

Nakamura

Tashiro³

et al. 1997

Br J Haematol

102

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Summary. Malignant histiocytosis (MH)-like B-cell lymphoma (BCL) is a neoplastic proliferation of large B cellsclinically characterized by fever, hepatosplenomegaly, haemophagocytosis and abnormal laboratory data, without lymphadenopathy or skin lesions. Interestingly, most cases have been reported in Asian patients, and it is unclear whether MH-like BCL is biologically distinct from conventional large B-cell lymphomas. We report five Japanese patients with MH-like BCL. Biopsied specimens of bone marrow, liver and/or spleen showed infiltration of neoplastic B cells accompanied by haemophagocytosing histiocytes. Lymphoma cells were positive for CD19, CD20 and HLA-DR surface antigens, and negative for CD5 and CD10. In four cases elevated serum levels of interleukin (IL)-6 and the soluble IL-2 receptor isoform were noted, but not IL-1b, IL-2 or tumour necrosis factor-a. Autopsies of two cases were pathologically diagnosed as intravascular lymphomatosis (IVL). Based on these observations, the current and nine previous cases reported as MH-like BCL in Japan were reevaluated. They appear to form a peculiar variant of IVL, characterized by bone marrow involvement at presentation, haemophagocytic syndrome, and a rapidly aggressive clinical course, but rarely neurological complications or skin lesions. This variant may merit separate consideration because of the problems posed in the initial diagnosis and therapeutic approaches.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Malignant histiocytosis‐like B‐cell lymphoma, a distinct pathologic variant of intravascular lymphomatosis: a report of five cases and review of the literature

Murase¹,

Nakamura

Tashiro³

et al. 1997

Br J Haematol

102

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“…However, its detailed clinicopathological features and follow‐up information remain limited, as most studies about AIVL or BCL‐HS are case reports, indicating the diagnostic difficulties while patients are alive (Shibuya et al , 1983; Sakai et al , 1991; Imai et al , 1992; Yamada et al , 1996). This may be caused in part by an imprecise definition or criteria of the disease.…”

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confidence: 99%

“…However, three of these cases were excluded from the study because of inadequate biopsy or post‐mortem specimens. The current series included 11 cases that have been reported previously as BCL‐HS in Japanese (Sakai et al , 1991; Imai et al , 1992; Yamada et al , 1996) or in English (Murase et al , 1997; Shimazaki et al , 1999). Biopsies from all cases and post‐mortem specimens from 11 autopsied cases were submitted for review to the Department of Pathology and Clinical Laboratories, Aichi Cancer Centre Hospital.…”

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confidence: 99%

An Asian variant of intravascular large B‐cell lymphoma: clinical, pathological and cytogenetic approaches to diffuse large B‐cell lymphoma associated with haemophagocytic syndrome

et al. 2000

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Diffuse large B-cell lymphoma with haemophagocytic syndrome (BCL-HS) has been reported mainly in Asia and is regarded as a distinct variant of intravascular lymphoma (IVL). However, it is unclear whether all cases of BCL-HS fall within the framework of IVL and available clinical information is limited. We analysed 25 cases with BCL-HS, including 11 autopsied cases (median, 66 years; male-female ratio, 1.1:1). The patients presented with fever, anaemia, thrombocytopenia, hepatosplenomegaly, haemophagocytosis, bone marrow invasion, respiratory disturbance and disseminated intravascular coagulopathy, but usually lacked lymphadenopathy, mass formation, neurological abnormalities and skin lesions. The clinical course was aggressive with a median survival of 7 months. The morphological findings were uniform: large lymphoid cells infiltrated vessels and/or sinusoids of the liver, marrow, lung, kidney and other organs. They were positive for CD19, CD20, CD79a and HLA-DR, but negative for CD10, CD23 and CD30. CD5 was positive in five out of 17 cases. Our critical review indicates that BCL-HS is the equivalent of the Asian variant of IVL.

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B‐cell lymphoma associated with haemophagocytic syndrome: a clinical, immunological and cytogenetic study

et al. 1999

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B‐cell lymphoma associated with haemophagocytic syndrome (HPS) is extremely rare in Western countries but has recently been increasingly reported in Asian countries. We describe seven patients with B‐cell lymphoma associated with HPS, six males and one female, age range 41–82 years (median 63 years). All patients had fever and splenomegaly, and six of the seven patients had hepatomegaly with no associated lymphadenopathy. The bone marrow showed haemophagocytosis and an infiltration of lymphoma cells. All patients showed increased levels of lactate dehydrogenase, C‐reactive protein, ferritin and soluble interleukin‐2 receptor. Lymphoma cells were positive for CD19, CD20 and surface immunoglobulin in all patients examined, and positive for CD5 in four of seven patients. Cytogenetic analyses of bone marrow cells showed a complex structural abnormality including chromosome 14q32 in two patients, 19q13 in three patients and deletion of the terminal part of 8p21 in six patients. The prognosis was poor; only two of the seven patients have survived in complete remission with a median survival of 11 months. These data suggested that B‐cell lymphoma associated with HPS might constitute a distinct biological and clinical disease entity. Abnormality of chromosome 19q13 and loss of 8p21 might be involved in the pathogenesis of this disease.

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Diffuse B cell lymphoma without lymphadenopathy accompanied by reactive histiocytosis simulating malignant histiocytosis: A report of three autopsy cases.

Abstract: The clinical and autopsy findings of three cases of B cell lymphoma simulating malignant histiocytosis are reported. Case 1 was 60y.o. female, case 2 was 75y.o.male and case 3 was 61y.o.female.

Cited by 3 publications

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Malignant histiocytosis‐like B‐cell lymphoma, a distinct pathologic variant of intravascular lymphomatosis: a report of five cases and review of the literature

Malignant histiocytosis‐like B‐cell lymphoma, a distinct pathologic variant of intravascular lymphomatosis: a report of five cases and review of the literature

An Asian variant of intravascular large B‐cell lymphoma: clinical, pathological and cytogenetic approaches to diffuse large B‐cell lymphoma associated with haemophagocytic syndrome

B‐cell lymphoma associated with haemophagocytic syndrome: a clinical, immunological and cytogenetic study

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