Diffractive optical coupling element for surface plasmon resonance sensors

Thirstrup, Carsten; Zong, W.; Borre, Martin B.; Neff, H.; Pedersen, Henrik C.; Holzhueter, G.

doi:10.1016/j.snb.2004.01.010

Cited by 83 publications

(52 citation statements)

References 32 publications

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“…A frequently derived quantity from the shift θ RES or λ RES is the temporal variation of an effective refractive index n A , from which binding kinetics and thickness variations of immobilized biochemical or other adsorbed films can be estimated [9] . Surface conditions of polycrystalline sputtered virgin gold films, exposed to an aqueous solution environment, are poorly defined, unstable and crucially depend on whether the metal surface behaves at a hydrophobic or hydrophilic state.…”

Section: Introductionmentioning

confidence: 99%

Line Shape Analysis and Extended Instrumental Operation of Surface Plasmon Resonance Sensors

et al. 2010

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Line shape effects of the surface plasmon resonance (SPR) at the gold-water interface have been exploited, towards extending instrumental performance in the angular interrogation mode. Comprising a microfluidic set-up both, SPR-line broadening and associated signal symmetry/asymmetry features have been monitored in real time for selected adsorption systems and are compared with the simultaneously taken resonance angle that represents the commonly recorded SPR feature. Four angular broadening contributions have been identified: an intrinsic, temperature independent fraction, a temperature dependent part that dominates at ambient temperature, a surface morphology/roughness contribution and an adsorption related fraction. The latter, and substantially smaller contribution, is crucially affected by surface conditions, as the transition from hydrophobic to a hydrophilic surface state. Anionic sub-monolayer adsorption has been clearly resolved, along with detection of a pronounced calorimetric effect that originates from an exothermic surface reaction upon exposure of the protein covered gold surface to a strong chemical oxidant.

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Section: Introductionmentioning

confidence: 99%

Line Shape Analysis and Extended Instrumental Operation of Surface Plasmon Resonance Sensors

et al. 2010

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“…Two polymer SPR biochips have been employed in the experiments: one, proposed in 2004 [5] and called VIRChip. It only works at the AIM case and has diffractive optical coupling elements (DOCEs), manufactured in nanometer dimensions by using holographic techniques; another, proposed in 2009 [6], called PPBIO.…”

Section: Methodsmentioning

confidence: 99%

Leishmania spp. Detection Using a Surface Plasmon Resonance Biosensor

Ferreira

Lima

Alves-Balvedi

et al. 2017

Proceedings of Eurosensors 2017, Paris, France, 3–6 September 2017

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Abstract:The detection of Leishmania spp. through a disposable surface plasmon resonance (SPR) biochip, using mono-and polychromatic sources, is presented here. A highly specific and sensitiveconstrained synthetic peptide (LC2) derived from a mimotope of Leishmania chagasi antigen was immobilized on the sensing region using a simple protocol. ELISA-and PCR-confirmed negative and positive sera of Leishmania chagasi infected patients were used. Detection of positive IgG showed a fast response with good sensitivity and specificity for the proposed method.

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“…Attempts to integrate SPR biosensor apparatus, in order to reduce size and cost, have been proposed, like the use of: polymer-based prisms, using packaged (Chinowsky et al, 2003;Chinowsky et al, 2007;Elkind et al, 1999) or non-packaged arrangements (Loureiro et al, 2009;Loureiro et al, 2011;Moreira et al, 2009 andThirstrup et al, 2004), conventional (Cennamo et al 2013) and microstructured (Dash and Jha, 2014) optical fibers, silicon-based devices (Ghosh andRay, 2015 andPatskovsky et al, 2003) and nanoparticles-based devices (Atar et al, 2015;Rivero et al, 2012;Sener et al, 2011 andWillets andVan Duyne, 2007). For the nanoparticles-based devices the associated physics is different than SPR physics and the phenomenon is known as Localized SPR or LSPR.…”

Section: Theoretical Aspectsmentioning

confidence: 99%

“…Another commercial SPR sensor chip proposed in 2004 (Neff et al, 2005;Thirstrup et al, 2004), called VIRChip uses a flat disposable optical chip, equipped with two integrated focusing / defocusing diffractive grating elements (DOCE´s) for internal beam forming and guiding to and from the sensing surface. The optical chip is made from TOPAS polymer material, producible in a high volume injection molding process, thus accounting for very low chip cost.…”

Section: Polymer-based Spr Devicesmentioning

confidence: 99%

“…The optical chip is made from TOPAS polymer material, producible in a high volume injection molding process, thus accounting for very low chip cost. The set-up leads to drastic reduction in instrumental volume, simplified optical design and practically maintenance free operation (Thirstrup et al, 2004). VIRChip has been applied only for AIM applications.…”

Section: Polymer-based Spr Devicesmentioning

confidence: 99%

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Polymer-based surface plasmon resonance biochip: construction and experimental aspects

et al. 2016

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Introduction: Surface plasmon resonance biosensors are high sensitive analytical instruments that normally employ glass materials at the optical substrate layer. However, the use of polymer-based substrates is increasing in the last years due to favorable features, like: disposability, ease to construction and low-cost design. Review: Recently, a polymer-based SPR biochip was proposed by using monochromatic and polychromatic input sources. Its construction and experimental considerations are detailed here. Experimental considerations and results, aspects from performance characteristics (resonance parameters, sensitivity and full width at half maximum -FWHM -calculations) are presented for hydrophilic and hydrophobic solutions. It is included also a brief description of the state of the art of polymer-based SPR biosensors.

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Diffractive optical coupling element for surface plasmon resonance sensors

Cited by 83 publications

References 32 publications

Line Shape Analysis and Extended Instrumental Operation of Surface Plasmon Resonance Sensors

Line Shape Analysis and Extended Instrumental Operation of Surface Plasmon Resonance Sensors

Leishmania spp. Detection Using a Surface Plasmon Resonance Biosensor

Polymer-based surface plasmon resonance biochip: construction and experimental aspects

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