Difficulties in Estimating Glomerular Filtration Rate in the Elderly

Goldberg, Todd H.; Finkelstein, Martin S.

doi:10.1001/archinte.1987.00370080066014

Cited by 103 publications

(49 citation statements)

References 18 publications

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“…They are based on the commonly used variables such as age, body weight, gender, and serum creatinine level. The Cockcroft and Gault formula (CG) [2] is one of the most often used, despite the growing doubts about its precision and accuracy, particularly in individuals with normal or near normal renal function [3,4]. Baracskay et al introduced a special equation, which was dedicated for elderly individuals [5].…”

Section: Introductionmentioning

confidence: 99%

Difference in estimated GFR with two different formulas in elderly individuals

et al. 2006

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The aim of this study was to characterize the differences between the prediction of GFR with Cockcroft-Gault formula (CG=(140-age)/(72 x PCr (mg/ml), for females multiplied by 0.85) and the new formula based on the multicenter trial of the Modification of Diet in Renal Diseases (MDRD=186 x P (Cr) (-1.154) x age(-0.203); 0.742 if patient is female) in elderly subjects. The study involved 100 individuals aged 65-111 years (mean age 88.3+/-14.7; 79 females and 21 males). In all subjects GFR was estimated according to both formulas mentioned above and expressed in ml/min/1.73 m2. Thereafter we calculated the difference between MDRD and CG (MDRD-CG) and analyzed its determinants in every subject. Mean GFR, obtained with MDRD was 76.0+/-24.0, whereas according to CG 67.9+/-18.6 (p < 0.0001). However, the mean MDRD-CG was up to 30.0+/-26.6 which means that MDRD results were much higher in comparison with CG. Using the multiple linear regression analysis we showed that MDRD-CG strongly depend on age (p < 0.0001), BMI (p < 0.0001) and serum creatinine concentration (p<0.0001). However, the gender has not effect on MDRD-CG value. The values of MDRD-CG strongly and positively correlated with age (r=0.7027, p < 0.0001) and negatively both with body mass index (r=-0.7171, p < 0.0001) and serum creatinine (r=-0.5590, p < 0.0001). In summary, our results show that the difference between MDRD and CG strongly depends on age, BMI and Scr. Investigators should be aware of these differences and take it into account in elderly.

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Section: Introductionmentioning

confidence: 99%

Difference in estimated GFR with two different formulas in elderly individuals

et al. 2006

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“…Low precision of serum creatinine measurements in the elderly population is well recognized [33]. Accurate measurement of GFR using clearance of inulin or radioactive tracers is unwieldy and expensive.…”

Section: Ageing Of the Kidneysmentioning

confidence: 99%

Acute kidney injury in the elderly population

Yılmaz

Erdem

2009

Int Urol Nephrol

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The elderly population is more prone to acute kidney injury (AKI) than younger populations. Older patients have less renal reserve because of reduced glomerular filtration rates due to anatomic/functional changes, and concomitant diseases such as hypertension, diabetes, atherosclerosis, heart failure, ischemic renal disease, and obstructive uropathy. The risk of AKI may also increase as a result of aggressive diagnostic and therapeutic procedures, which include medical agents, radiology, and surgical intervention. AKI in the elderly has a multifactorial physiopathology due to different etiologies. Studies that have specifically compared prognosis of AKI in elderly versus young over the recent years suggest that age is a predictor of long-term outcome. In most cases, the treatment of AKI is similar for all age groups. The majority of critically ill patients with AKI will eventually need renal replacement therapy (RRT). The influence of RRT on renal outcome remains a subject of intense investigation and debate. Avoiding situations that could damage the kidney is an important strategy to prevent AKI development in the elderly, besides medical and interventional therapeutics.

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“…À cet inconvénient majeur s'y associe souvent un second lié à un recueil d'urine incomplet. Aussi, on propose en pratique courante d'estimer la clairance de la créati-nine (Clcr) à l'aide de la formule de Cockcroft et Gault [3] : Ou par la formule simplifiée [8] : Néanmoins, cette méthode sousestime le débit de filtration glomé-rulaire en cas d'insuffisance rénale.…”

Section: Sur La Clairance De La Créatinineunclassified

�valuation de la fonction r�nale

Izzedine

Deray

2004

La Revue Francophone de Formation en Oncologie

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Difficulties in Estimating Glomerular Filtration Rate in the Elderly

Cited by 103 publications

References 18 publications

Difference in estimated GFR with two different formulas in elderly individuals

Difference in estimated GFR with two different formulas in elderly individuals

Acute kidney injury in the elderly population

�valuation de la fonction r�nale

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