Difference in estimated GFR with two different formulas in elderly individuals

Wieczorowska‐Tobis, Katarzyna; Niemir, Zofia I.; Guzik, Przemysław; Bręborowicz, Andrzej; Oreopoulos, Dimitrios G.

doi:10.1007/s11255-006-0065-7

Cited by 39 publications

(26 citation statements)

References 14 publications

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“…This has been reported recently from a similar group of elderly [31]. Using a paired samples t test, it shows that the mean difference was 13.6 ml in subjects <81 years and 23.1 in subjects >81 years (p = 0.006).…”

Section: Discussionsupporting

confidence: 81%

Differences in the Glomerular Filtration Rate Calculated by Two Creatinine-Based and Three Cystatin-C-Based Formulae in Hospitalized Elderly Patients

et al. 2007

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Background: Reduced renal function is a health problem in elderly patients. Different creatinine- and cystatin-C-based formulae have been used to estimate glomerular filtration rate (GFR). Aims: To investigate individual and group differences of GFR estimates derived from five different formulae. Methods: 60 patients were randomly assigned to participate in this cross-sectional study. Nutrition status was assessed, blood samples were drawn and GFR was calculated using two creatinine- and three cystatin-C-based formulae. Results: Four of five formulae indicate reduced GFR in >70% of the participants, GFR was significantly less in malnourished patients according to one creatinine formula. Estimates from the formulae were highly correlated (r = 0.607–0.863, p < 0.001), but individual differences were between –36.1 and 79.9 ml/min/1.73 m². The formulae grouped 38.3–60.0% of the subjects differently into the five stages of chronic kidney disease. BMI, total cholesterol, age and gender were significant predictors for the calculated GFR differences between the formulae. Conclusion: The prevalence of reduced renal function is high in elderly hospitalized patients. BMI, age and/or gender can affect GFR estimates depending on the formula used, and there is an association between total cholesterol and calculated GFR differences between formulae. Different formulae can result in a different grouping of patients into the five stages of chronic renal disease.

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Section: Discussionsupporting

confidence: 81%

Differences in the Glomerular Filtration Rate Calculated by Two Creatinine-Based and Three Cystatin-C-Based Formulae in Hospitalized Elderly Patients

et al. 2007

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“…These estimation formulas are prone to error particularly in the elderly population. 17 Nevertheless, these equations are practical and still widely used.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Kidney Dimensions Measured by Multi-detector Computed Tomography (MDCT) in 930 Middle-Aged and Elderly Patients

et al. 2011

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Purpose: A few studies investigated renal size using computed tomography (CT) in middle-aged and elderly patients while taking renal function into account. Thus, we aimed to assess kidney dimensions and their predictors in patients without known renal disease by multi-detector computed tomography (MDCT). Methods: This is a 6-month-long prospective observational study. Estimated glomerular filtration rate (eGFR) was calculated with Cockcroft-Gault (CG) and modification of diet in renal disease (MDRD) formulas. Pole-to-pole kidney length (R1) was determined from coronal and sagittal oblique images. Kidney length (R2), width (R3), and parenchymal thickness were measured in axial slices. Results: The data of the 930 patients were included in this study. CG-eGFR was more closely correlated with R1, R2, and R3 than MDRD-eGFR. CG-eGFR, female gender, and presence of diabetes mellitus were independent predictors of R1 size in logistic regression analyses. Conclusion: Kidney sizes diminish with advancing age. CG-eGFR shows a better correlation with kidney dimensions compared with MDRD. Overall, age was a stronger determinant of eGFR than renal dimensions.

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“…In addition, creatinine production depends on muscle mass and is age and sex-related. To apply the C&G formula, plasma creatinine must be in the steady state [14]. The formula is inaccurate in patients with liver disease, muscle wasting, oedema or extreme adiposity [14].…”

Section: Discussionmentioning

confidence: 99%

“…To apply the C&G formula, plasma creatinine must be in the steady state [14]. The formula is inaccurate in patients with liver disease, muscle wasting, oedema or extreme adiposity [14]. Furthermore, with creatinine, the ratio of glomerular filtration to tubular excretion varies unpredictably in pathologic states [16].…”

Section: Discussionmentioning

confidence: 99%

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Comparison of methods for determination of glomerular filtration rate: low and high-dose Tc-99m-DTPA renography, predicted creatinine clearance method, and plasma sample method

et al. 2008

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The gamma camera uptake method with Tc-99m-DTPA (diethylenetriaminepentaacetic acid) is a simple method for determination of glomerular filtration rate (GFR), and is less time-consuming than other methods, but its diagnostic accuracy is debated. Gate's method (low-dose; LD), the high-dose method (HD), the predicted-clearance method, and the plasmaclearance method with Tc-99m-DTPA are compared in this study. We also performed GFR measurement and diuretic renography simultaneously. Tc-99m DTPA renography was performed in 36 patients aged 18-72 years with a wide range of renal function (serum creatinine 1.37 ± 0.49 mg/dl). GFR was determined by four methods: the gamma camera uptake method with low-dose Tc-99m DTPA (Gates, LD); the gamma camera uptake method with high-dose Tc-99m DTPA (HD); the predicted creatinine clearance method (Cockcroft-Gualt, CG); and the plasma sample clearance (PSC) method using a mono-exponential curve. The PSC method was chosen as reference. The regression equations for the CG, Gates (low-dose), and HD methods against the PSC method were 28.68 + 0.80X (r = 0.72; P value \ 0.0001, RMSE = 21.65 ml/min/ 1.73 m 2 ), 6.19 + 0.79X (r = 0.90; P value \ 0.0001, RMSE = 10.64 ml/min/1.73 m 2 ), and 6.53 + 0.88X (r = 0.93; P value \ 0.0001, RMSE = 9.35 ml/min/ 1.73 m 2 ), respectively. In comparison with determination of GFR by the PSC method, the CG method tended to overestimate GFR while, perversely, the LD and HD methods tended to underestimate GFR. The three methods were in agreement with the PSC method but the high-dose GFR method resulted in less error in estimation of GFR. Furthermore, GFR measurement and diuretic renography could be performed at the same time when the high-dose method was used. Because of the low cost and negligible radiation burden, this method might be preferred for routine practice in nuclear medicine.

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Difference in estimated GFR with two different formulas in elderly individuals

Cited by 39 publications

References 14 publications

Differences in the Glomerular Filtration Rate Calculated by Two Creatinine-Based and Three Cystatin-C-Based Formulae in Hospitalized Elderly Patients

Differences in the Glomerular Filtration Rate Calculated by Two Creatinine-Based and Three Cystatin-C-Based Formulae in Hospitalized Elderly Patients

Predictors of Kidney Dimensions Measured by Multi-detector Computed Tomography (MDCT) in 930 Middle-Aged and Elderly Patients

Comparison of methods for determination of glomerular filtration rate: low and high-dose Tc-99m-DTPA renography, predicted creatinine clearance method, and plasma sample method

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