Differing mechanisms for proactive effects of intermittent and single shock on gastric ulceration

Overmier, J. Bruce; Murison, Robert

doi:10.1016/0031-9384(94)90323-9

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A New Empirical Approach: Search For Modulation1

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Cited by 10 publications

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“…Overmier & Murison, 1991). This effect of prior stress on later vulnerability is illustrated in Figure 2, 1 and it is thought to mediate its effects through opioid‐related mechanisms (Overmier & Murison, 1994).…”

Section: A New Empirical Approach: Search For Modulationmentioning

confidence: 99%

Restoring Psychology's Role in Peptic Ulcer

Overmier¹,

Murison

2012

Applied Psych Health & Well

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This paper reviews the history of the transition from the belief that gastrointestinal ulcers are caused primarily by psychological factors to the current state of belief that they are caused primarily by infection and argues that neither is fully accurate. We argue that psychological factors play a significant role as predisposing to vulnerability, modulating of precipitation, and sustaining of gastric ulceration. We review data that challenge the assumption of a simple infectious disease model and adduce recent preclinical data that confirm the predisposing, modulatory, and sustaining roles for psychological factors. We note that others, too, are now challenging the adequacy of the contemporary simple bacterial infection model. We hope to replace the competition between psychology and medicine with cooperation in understanding and treating patients suffering gastric ulceration and ulcer.

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Section: A New Empirical Approach: Search For Modulationmentioning

confidence: 99%