Differentiation of frontotemporal dementia from dementia with Lewy bodies using FP-CIT SPECT

Morgan, Shirlony; Kemp, P. M.; Booij, Jan; Costa, Durval C.; Padayachee, Shalandran; Lee, Lean; Barber, Christopher; Carter, Janet; Walker, Zuzana

doi:10.1136/jnnp-2012-302577

Cited by 80 publications

(66 citation statements)

References 41 publications

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“…No previously published studies contained the pronation/supination task in the Q-Motor protocol. The mean values of the clinical ratings in the UPDRS are similar to previous studies using UPDRS on AD, FTD, and DLB patients [3, 12, 17-19]. …”

Section: Discussionsupporting

confidence: 70%

“…The Unified Parkinson Disease Rating Scale Part-III (UPDRS) [16], a categorical clinical rating scale providing a subjective visual clinical evaluation of motor dysfunction, has been used to examine motor symptoms in AD, FTD, and DLB with varying results [3, 12, 17-20]. Further, both the MDS-UPDRS and the Unified Huntington Disease Rating Scale-Total Motor Score (UHDRS-TMS) [21] are subject to rater bias and risk of consecutive intra- and interrater variability and error [16, 22].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Quantitative Measurements of Motor Function in Alzheimer’s Disease, Frontotemporal Dementia, and Dementia with Lewy Bodies: A Proof-of-Concept Study

Kragh

Bruun

Budtz‐Jørgensen

et al. 2018

Dement Geriatr Cogn Disord

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Background: This study examines the efficacy of using quantitative measurements of motor dysfunction, compared to clinical ratings, in Alzheimer’s disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB). Methods: In this cross-sectional study, 49 patients with a diagnosis of AD (n = 17), FTD (n = 19), or DLB (n = 13) were included and underwent cognitive testing, clinical motor evaluation, and quantitative motor tests: pronation/supination hand tapping, grasping and lifting, and finger and foot tapping. Results: Our results revealed significantly higher Q-Motor values in pronation/supination and in grip lift force assessment in AD, FTD, and DLB compared to healthy controls (HC). Q-Motor values detected significant differences between AD and HC, while clinical ratings did not. Conclusion: Our results suggest that quantitative measurements provide more objective and sensitive measurements of motor dysfunction in dementia.

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Section: Discussionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Quantitative Measurements of Motor Function in Alzheimer’s Disease, Frontotemporal Dementia, and Dementia with Lewy Bodies: A Proof-of-Concept Study

Kragh

Bruun

Budtz‐Jørgensen

et al. 2018

Dement Geriatr Cogn Disord

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“…Differentiating DLB from frontotemporal dementia on the basis of DAT imaging may be less distinct. In a recent study, one third of the patients with frontotemporal dementia (4/12) presented with reduced DAT binding (74). Further studies are needed to determine whether nigrostriatal loss in frontotemporal dementia is quantitatively distinct from DLB and PDD.…”

Section: Differential Diagnosis Of Dlbmentioning

confidence: 99%

Nigrostriatal Dopamine Terminal Imaging with Dopamine Transporter SPECT: An Update

2013

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Learning Objectives: On successful completion of this activity, participants should be able to describe (1) the radiopharmaceuticals used to evaluate nigrostriatal dopamine imaging; (2) the pattern of uptake of these radiopharmaceuticals in parkinsonian syndromes; and (3) the role of these radiopharmaceuticals in the evaluation of parkinsonian syndromes.Financial Disclosure: Dr. Tatsch is a meeting participant/lecturer for GE Healthcare. The authors of this article have indicated no other relevant relationships that could be perceived as a real or apparent conflict of interest. CME Credit: SNMMI is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to sponsor continuing education for physicians. SNMMI designates each JNM continuing education article for a maximum of 2.0 AMA PRA Category 1 Credits. Physicians should claim only credit commensurate with the extent of their participation in the activity. For CE credit, participants can access this activity through the SNMMI Web site (http:// www.snmmi.org/ce_online) through August 2016.This article gives an update on nigrostriatal dopamine terminal imaging, with emphasis on SPECT performed with the presynaptic dopamine transporter (DAT) ligand 123 I-FP-CIT. The paper covers the rational use of this technique in the diagnostic work-up of patients with known or suspected parkinsonian syndromes. In detail, it addresses the impact of the method for the proof or exclusion of neurodegenerative parkinsonism, for its early and preclinical diagnosis, and for the evaluation of disease progression. The importance of normal DAT binding for differentiating symptomatic parkinsonism and relevant tremor syndromes from neurodegeneration is highlighted. Particularly emphasized is the role of DAT SPECT for diagnosing Lewy body dementia and its separation from Alzheimer dementia. Finally, some remarks deal with the economic aspects of the use of these imaging techniques in the clinical setting.

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“…8 And finally, ( 123 I)FP-CIT SPECT is helpful in differentiating dementia with LBD from AD, but not with LBD from frontotemporal lobe dementia. 9 This last SPECT is also probably little used because of the cost. 10 That is the reason why we really need more clinical data to better diagnose LBD patients, particularly at the beginning of the disease.…”

Section: F Blancmentioning

confidence: 99%

Does cognitive profile distinguish Lewy body disease from Alzheimer's disease in the early stages?

Blanc

2013

J Neurol Neurosurg Psychiatry

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Differentiation of frontotemporal dementia from dementia with Lewy bodies using FP-CIT SPECT

Abstract: This study highlights to clinicians that a positive (abnormal) [123I]FP-CIT SPECT scan, even in a patient with an EPMS, does not exclude the diagnosis of FTD and emphasises the importance of a comprehensive clinical evaluation and a detailed cognitive assessment.

Cited by 80 publications

References 41 publications

Quantitative Measurements of Motor Function in Alzheimer’s Disease, Frontotemporal Dementia, and Dementia with Lewy Bodies: A Proof-of-Concept Study

Quantitative Measurements of Motor Function in Alzheimer’s Disease, Frontotemporal Dementia, and Dementia with Lewy Bodies: A Proof-of-Concept Study

Nigrostriatal Dopamine Terminal Imaging with Dopamine Transporter SPECT: An Update

Does cognitive profile distinguish Lewy body disease from Alzheimer's disease in the early stages?

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