Does cognitive profile distinguish Lewy body disease from Alzheimer's disease in the early stages?

Blanc, F.

doi:10.1136/jnnp-2012-304694

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…For instance, our research group found a faster decline in DLB than AD over 5 years (4.4 vs 3.2 points on average per year) ( 8 ). In the second study, patients with mixed AD and DLB were shown to decline faster than AD or DLB, and in the last one, they found some indications of a faster decline in DLB than in AD and Parkinson’s disease dementia (PDD) ( 9 , 10 ).…”

Section: Introductionmentioning

confidence: 95%

A Longitudinal Study of Neurocognition in Dementia with Lewy Bodies Compared to Alzheimer’s Disease

et al. 2018

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IntroductionThere are relatively few longitudinal studies on the differences in cognitive decline between Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB), and the majority of existing studies have suboptimal designs.AimWe investigated the differences in cognitive decline in AD compared to DLB over 4 years and cognitive domain predictors of progression.MethodsIn a longitudinal study, 266 patients with first-time diagnosis of mild dementia were included and followed annually. The patients were tested annually with neuropsychological tests and screening instruments [MMSE (Mini-Mental Status Examination), Clinical Dementia Rating (CDR), the second edition of California Verbal Learning Test (CVLT-II), Trail Making Test A & B (TMT A & B), Stroop test, Controlled Oral Word Associations Test (COWAT) animal naming, Boston Naming Test, Visual Object and Space Perception Battery (VOSP) Cubes and Silhouettes]. Longitudinal analyses were performed with linear mixed effects (LME) models and Cox regression. Both specific neuropsychological tests and cognitive domains were analyzed.ResultsThis study sample comprised 119 AD and 67 DLB patients. In TMT A, the DLB patients had a faster decline over 4 years than patients with AD (p = 0.013). No other longitudinal differences in specific neuropsychological tests were found. Higher executive domain scores at baseline were associated with a longer time to reach severe dementia (CDR = 3) or death for the total sample (p = 0.032). High or low visuospatial function at baseline was not found to be associated with cognitive decline (MMSE) or progression of dementia severity (CDR) over time.ConclusionOver 4 years, patients with DLB had a faster decline in TMT A than patients with AD, but this should be interpreted cautiously. Beyond this, there was little support for faster decline in DLB patients neuropsychologically than in AD patients.

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Section: Introductionmentioning

confidence: 95%

A Longitudinal Study of Neurocognition in Dementia with Lewy Bodies Compared to Alzheimer’s Disease

et al. 2018

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“…Taking into account the different neuropsychological profiles of the above-listed neurodegenerative entities (roughly: greater attention and executive decline in DLB, PD, and FTLD and more prominent episodic memory decline in ad ), it is possible that their “MCI equivalents” might share analogous neuropsychological disparities ( Blanc, 2013 ; Dalrymple-Alford, 2001 ; Hamilton et al., 2021 ; Sadiq et al., 2017 ). Language performance is quite complex in the number of cognitive functions needed to perform it, with verbal fluency tasks being heavily based on both executive skills and semantic memory stores, whereas naming, comprehension, and repetition tasks rely on the semantic reservoir as well as perceptual skills ( Amunts, Camilleri, Eickhoff, Heim, & Weis, 2020 ; Brouillette et al., 2011 ; Hodges, Salmon, & Butters, 1990 ; Kavé & Sapir-Yogev, 2020 ; Rende, Ramsberger, & Miyake, 2002 ; Rohrer et al., 2007 ).…”

Section: Introductionmentioning

confidence: 99%

Language Differences Among Individuals with Normal Cognition, Amnestic and Non-Amnestic MCI, and Alzheimer’s Disease

Liampas

Folia

Morfakidou

et al. 2022

Archives of Clinical Neuropsychology

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Objective To investigate differences in language performance among older adults with normal cognition (CN), mild cognitive impairment (MCI), and Alzheimer’s disease (ad). Owing to the conflicting literature concerning MCI, discrepancies between amnestic (aMCI) and non-amnestic MCI (naMCI) were explored in greater detail. Method The study sample was drawn from the older (>64 years) HELIAD cohort. Language performance was assessed via semantic and phonemic fluency, confrontation naming, verbal comprehension, verbal repetition as well as a composite language index. Age, sex, and education adjusted general linear models were used to quantify potential pairwise differences in language performance. Results The present analysis involved 1607 participants with CN, 146 with aMCI [46 single and 100 multi-domain aMCI], 92 with naMCI [41 single and 51 multi-domain naMCI], and 79 with ad. The mean age and education of our predominantly female (60%) participants were 73.82 (±5.43) and 7.98 (±4.93) years, respectively. MCI individuals performed between those with CN and ad, whereas participants with aMCI performed worse compared to those with naMCI, especially in the semantic fluency and verbal comprehension tasks. Discrepancies between the aMCI and naMCI groups were driven by the exquisitely poor performance of multi-domain aMCI subgroup. Conclusions Overall, individuals could be hierarchically arranged in a continuum of language impairment with the CN individuals constituting the healthy reference and naMCI, aMCI, ad patients representing gradually declining classes in terms of language performance. Exploration of language performance via separation of single from multi-domain naMCI provided a potential explanation for the conflicting evidence of previous research.

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Does cognitive profile distinguish Lewy body disease from Alzheimer's disease in the early stages?

Cited by 2 publications

References 14 publications

A Longitudinal Study of Neurocognition in Dementia with Lewy Bodies Compared to Alzheimer’s Disease

A Longitudinal Study of Neurocognition in Dementia with Lewy Bodies Compared to Alzheimer’s Disease

Language Differences Among Individuals with Normal Cognition, Amnestic and Non-Amnestic MCI, and Alzheimer’s Disease

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