Differentiation of cysts from solid tumors in the breast with diffuse optical tomography1

Gu, Xuejun; Zhang, Qizhi; Bartlett, Matthew; Schutz, Leonard; Fajardo, Laurie L.; Jiang, Huabei

doi:10.1016/s1076-6332(03)00562-2

Cited by 69 publications

(50 citation statements)

References 16 publications

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“…Intra-and interobserver agreement were good to excellent, indicating a reproducible method. Our results are in agreement with previously published studies using different techniques [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. Detection rates ranging from 0.04 to 1.00 were reported, irrespective of lesion classification (benign/malignant).…”

Section: Discussionsupporting

confidence: 93%

Diffuse optical tomography of the breast: preliminary findings of a new prototype and comparison with magnetic resonance imaging

et al. 2009

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This paper presents an evaluation of a prototype diffuse optical tomography (DOT) system. Seventeen women with 18 breast lesions (10 invasive carcinomas, 2 fibroadenomas, and 6 benign cysts; diameters 13-54 mm) were evaluated with DOT and magnetic resonance imaging (MRI). A substantial fraction of the original 36 recruited patients could not be examined using this prototype due to technical problems. A region of interest (ROI) was drawn at the lesion position as derived from MRI and at the mirror image site in the contralateral healthy breast. ROIs were assessed quantitatively and qualitatively by two observers independently in two separate readings. Intra-and interobserver agreements were calculated using kappa statistics (k) and intraclass correlation coefficients (ICCs). Discriminatory values for presence of malignancy were determined by receiver operating characteristic (ROC) analyses. Intraobserver agreements were excellent (k 0.88 and 0.88; ICC 0.978 and 0.987), interobserver agreements were good to excellent (k 0.77-0.95; ICC 0.96-0.98). Discriminatory values for presence of malignancy were 0.92-0.93 and 0.97-0.99 for quantitative and qualitative ROC analysis, respectively. This DOT system has the potential to discriminate malignant from benign breast tissue in a reproducible qualitative and quantitative manner. Important technical improvements are required before this technique is ready for clinical application.

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Section: Discussionsupporting

confidence: 93%

Diffuse optical tomography of the breast: preliminary findings of a new prototype and comparison with magnetic resonance imaging

et al. 2009

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“…A large amount of work has been performed on the utilisation of light to noninvasively study human tissues [1,2] and to deliver various treatments [3]. These positive results are based on a good understanding of light transport in turbid media, the availability of powerful numerical tools and a precise knowledge of the optical properties of the biological materials of interest.…”

Section: Introductionmentioning

confidence: 99%

Shape based Monte Carlo code for light transport in complex heterogeneous Tissues

Margallo-Balbás

French

2007

Opt. Express

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A Monte Carlo code for the calculation of light transport in heterogeneous scattering media is presented together with its validation. Triangle meshes are used to define the interfaces between different materials, in contrast with techniques based on individual volume elements. This approach allows to address realistic problems in a flexible way. A hierarchical spatial organisation enables a fast photon-surface intersection test. The application of the new environment to evaluate the impact of the trabecular structure of bone on its optical properties is demonstrated. A model of the trabecular micro structure recovered from microCT data was used to compute light distribution within tissue. Time-resolved curves across a spherical bone volume were computed. The work presented enables simulation of radiative transport in complex reality-based models of tissue and serves as a powerful, generic tool to study the effect of heterogeneity in the field of biomedical optics. 547-560 (1998 193-206 (1998). 24. A. Pifferi, A. Torricelli, P. Taroni, A. Bassi, E. Chikoidze, E. Giambattistelli, and R. Cubeddu, "Optical biopsy of bone tissue: a step toward the diagnosis of bone pathologies," J. Biomed. Opt. 9(3), 474-479 (2004).

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“…The system was developed based on experience with an existing MR-guided NIRST approach [34], but for the purpose of dynamic monitoring of responses to neoadjuvant chemotherapy within the infusion suite. Studies utilizing diffuse optical tomography technique typically incorporate less than 4 wavelengths in the range of 680 -850nm [6,7,42,43], which inhibits accurate recovery of water and lipid content. Here, three FD wavelengths and six CW wavelengths provided coverage in the range of 661 -1064nm.…”

Section: Discussionmentioning

confidence: 99%

Portable, parallel 9-wavelength near-infrared spectral tomography (NIRST) system for efficient characterization of breast cancer within the clinical oncology infusion suite

Zhao¹,

Pogue²,

Haider³

et al. 2016

Biomed. Opt. Express

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A portable near-infrared spectral tomography (NIRST) system was developed with simultaneous frequency domain (FD) and continuouswave (CW) optical measurements for efficient characterization of breast cancer in a clinical oncology setting. Simultaneous FD and CW recordings were implemented to speed up acquisition to 3 minutes for all 9 wavelengths, spanning a range from 661nm to 1064nm. An adjustable interface was designed to fit various breast sizes and shapes. Spatial images of oxy-and deoxy-hemoglobin, water, lipid, and scattering components were reconstructed using a 2D FEM approach. The system was tested on a group of 10 normal subjects, who were examined bilaterally and the recovered optical images were compared to radiographic breast density. Significantly higher total hemoglobin and water were estimated in the high density relative to low density groups. One patient with invasive ductal carcinoma was also examined and the cancer region was characterized as having a contrast ratio of 1.4 in total hemoglobin and 1.2 in water. ©2016 Optical Society of America

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Differentiation of cysts from solid tumors in the breast with diffuse optical tomography1

Cited by 69 publications

References 16 publications

Diffuse optical tomography of the breast: preliminary findings of a new prototype and comparison with magnetic resonance imaging

Diffuse optical tomography of the breast: preliminary findings of a new prototype and comparison with magnetic resonance imaging

Shape based Monte Carlo code for light transport in complex heterogeneous Tissues

Portable, parallel 9-wavelength near-infrared spectral tomography (NIRST) system for efficient characterization of breast cancer within the clinical oncology infusion suite

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