Differentiation of Chronic Focal Pancreatitis From Pancreatic Carcinoma by In Vivo Proton Magnetic Resonance Spectroscopy

Cho, Soon Gu; Lee, Don Haeng; Lee, Keon Young; Ji, Hoon; Lee, Kyung Hee; Ros, Pablo R.; Suh, Chang Hae

doi:10.1097/01.rct.0000153956.33296.b5

Cited by 68 publications

(36 citation statements)

References 46 publications

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“…With in vivo 1 H MRS technology, clinical research has concluded that lipid in chronic focal pancreatitis is significantly less than that observed in pancreatic carcinoma tissues (37). Cancerous tissues generally have high lipid content, but the reverse is not always true for other pancreatic diseases, as tissue lipid content varies widely due to factors such as genetics, aging, gender and the environment.…”

Section: Discussionmentioning

confidence: 99%

Metabolic characteristics of acute necrotizing pancreatitis and chronic pancreatitis

Tian

Wang

et al. 2012

Mol Med Report

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Abstract. The etiology and pathogenesis of pancreatitis remains unclear. In the presence of pancreatic inflammation, metabolite abnormalities appear before transformation of tissue structure and changes in functions occur. Detection of abnormalities in metabolite levels facilitates a greater understanding of the pathophysiological events and aids in the early diagnosis of the disease. In this study, metabolic profiles from the pancreas of Wistar rats were examined using high-resolution proton magic angle spinning nuclear magnetic resonance (MAS NMR) spectroscopy to investigate the metabolite indicator(s) of acute necrotizing pancreatitis (ANP) and chronic pancreatitis (CP). The animals were divided into three groups: those with histologically confirmed ANP (n=7), those with CP (n=6) and a control group (n=9). The processed NMR spectra were analyzed using principal component analysis (PCA) to extract characteristic metabolites of ANP and CP. Levels of leucine, isoleucine and valine were increased in the ANP group, whereas an opposite trend was observed in the CP group. Increases in phosphocholine, glycerophosphocholine and choline levels, and decreases in fatty acids, lactate, betaine and glycine levels were observed in both the ANP and CP groups. Additionally, the lipid content in the CP group was higher than that observed in the ANP group. An increase in taurine levels was observed only in the CP group. In conclusion, pancreatitis causes a disruption of the metabolism in the pancreas at a molecular level, with increased taurine levels being a potential metabolite indicator for those with CP.

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Section: Discussionmentioning

confidence: 99%

Metabolic characteristics of acute necrotizing pancreatitis and chronic pancreatitis

Tian

Wang

et al. 2012

Mol Med Report

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“…From last few years its use has been tried in many other tumors including esophagus [18], colon [19], prostate [20], pancreas [21], breast [22] and cervix [23]. In MRS instead of detecting the magnetic resonance of water (as done in conventional MRI); various other chemical compounds are detected.…”

Section: Imaging Studies a Magnetic Resonance Spectroscopy (Mrs)mentioning

confidence: 99%

Newer Diagnostic Methods in Oncology

Goyal

Hingmire

Parikh

2006

Medical Journal Armed Forces India

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“…110 1 H MRS has also been used to study tumors of the breast, pancreas, cervix, and thyroid gland. 111 31 P MRS also has potential utility to noninvasively assess tumors. It has shown some promise to differentiate prostate carcinoma from benign prostatic hypertrophy.…”

Section: -108mentioning

confidence: 99%

“…Whole-body SSTR imaging is performed with radiolabeled derivatives of octreotide, which have a preference for subtype 2 SSTRs (ie, SSTR 2 ). The most commonly used agent is 111 In-pentetreotide for SPECT imaging, although SSTR-targeted tracers have also been developed for PET, including 68 Ga-DPhe1-Tyr3-octrotide ( 68 Ga-DOTATOC) and Gluc-Lys( Ga-DOTATOC in the assessment of neuroendocrine tumors. 77 …”

Section: Somatostatin Receptorsmentioning

confidence: 99%

Functional Imaging of Cancer with Emphasis on Molecular Techniques

Torigian

Huang

Houseni

et al. 2007

CA: A Cancer Journal for Clinicians

123

105

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A multitude of noninvasive, quantitative, functional imaging techniques are currently in use to study tumor physiology, to probe tumor molecular processes, and to study tumor molecules and metabolites in vitro and in vivo using computed tomography (CT), magnetic resonance imaging (MRI), ultrasonography (US), positron emission tomography (PET), single-photon emission computed tomography (SPECT), and optical imaging (OI). Such techniques can be used in conjunction with structural imaging techniques to detect, diagnose, characterize, or monitor tumors before and after therapeutic intervention. These can also be used to study tumor gene expression, to track cells and therapeutic drugs, to optimize individualized treatment planning for patients with tumors, and to foster new oncologic drug development.In this article, we review the rich variety of functional imaging techniques that are available for these purposes, which are becoming increasingly important for optimal individualized patient treatment in this day and age of "personalized medicine." (CA Cancer J Clin 2007;57:206-224.)

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Differentiation of Chronic Focal Pancreatitis From Pancreatic Carcinoma by In Vivo Proton Magnetic Resonance Spectroscopy

Abstract: Chronic focal pancreatitis and pancreatic carcinoma can be distinguished from each other by analysis of in vivo H-MR spectra, and in vivo H-MRS can be a useful method for making a differential diagnosis between chronic focal pancreatitis and pancreatic carcinoma.

Cited by 68 publications

References 46 publications

Metabolic characteristics of acute necrotizing pancreatitis and chronic pancreatitis

Metabolic characteristics of acute necrotizing pancreatitis and chronic pancreatitis

Newer Diagnostic Methods in Oncology

Functional Imaging of Cancer with Emphasis on Molecular Techniques

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