Differentiation of Benign From Malignant Focal Splenic Lesions Using Sulfur Hexafluoride–Filled Microbubble Contrast-Enhanced Pulse-Inversion Sonography

Stang, Axel; Keles, Handan; Hentschke, Suna; Seydewitz, Cay Uwe von; Dahlke, Joachim; Malzfeldt, Ernst; Braumann, D.

doi:10.2214/ajr.07.3988

Cited by 55 publications

(65 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[10][11][12]18,19 Several studies have described the contrast-enhanced sonographic findings of various splenic lesions. 14,26,27 Benign vascular tumors in the spleen typically present as isoenhancement or a short period of slight hyperenhancement during the arterial phase and isoenhancement or hypoenhancement during the parenchymal phase. Malignant tumors in the spleen usually present as progressively hypoenhancing patterns.…”

Section: Discussionmentioning

confidence: 99%

Littoral Cell Angioma of the Spleen

Yunhua

Liu

Wang

et al. 2013

Journal of Ultrasound in Medicine

View full text Add to dashboard Cite

Objectives The purpose of this study was to evaluate the sonographic and pathologic features of littoral cell angioma of the spleen in 7 patients. Methods The sonographic appearance in 7 cases of littoral cell angioma confirmed by surgical pathologic examination was retrospectively reviewed. All underwent color Doppler imaging. Two underwent contrast‐enhanced sonography. The sonographic appearance was compared with pathologic findings. Results Splenic lesions were solitary in 5 cases and multiple in 2 cases. The masses ranged from 10 to 64 mm in maximum diameter. Five hypoechoic and 2 hyperechoic lesions on grayscale sonography corresponded to few and multiple blood‐filled spaces on pathologic examination, respectively. Four hypovascular lesions, 1 hypervascular lesion, and the other 2 hypervascular lesions full of color flow signals on color Doppler imaging corresponded to few, several, and multiple arteries on pathologic examination. On contrast‐enhanced sonography, 1 hypervascular lesion full of color flow signals showed homogeneous hyperenhancement for 8 minutes during the arterial and parenchymal phases. One hypovascular lesion showed inhomogeneous isoenhancement transiently during the arterial phase and became hypoechoic later. Conclusions Littoral cell angioma is a primary vascular splenic neoplasm with variable features on grayscale sonography and color Doppler imaging as well as contrast‐enhanced sonography. The sonographic appearance of littoral cell angioma mainly depends on the type and number of tumor vessels.

show abstract

Section: Discussionmentioning

confidence: 99%

Littoral Cell Angioma of the Spleen

Yunhua

Liu

Wang

et al. 2013

Journal of Ultrasound in Medicine

View full text Add to dashboard Cite

show abstract

“…Hemangiomas are composed of vascular channels of variable size, ranging from capillary to cavernous, which are lined with a single layer of endothelium filled with red blood cells (5). According to the predominant component (either capillary or cavernous) hemangiomas adopt different sonographic patterns.…”

Section: Discussionmentioning

confidence: 99%

Contribution of contrast enhanced sonography in the etiological diagnosis of focal splenic lesions

Casanova-Martínez

Marín-Serrano

Jaquotot-Herranz

et al. 2012

Rev. esp. enferm. dig.

View full text Add to dashboard Cite

“…The combination of contrast enhancement in the early phase followed by rapid wash-out and demarcation of the lesion without contrast enhancement in the parenchymal phase (60 s after injection) was typical for malignant lesions [45] . For correct diagnosis of benignancy or malignancy, the overall accuracy was 43%-74% before CEUS vs 81%-92% after CEUS [46] . CEUS improves the characterization of focal splenic lesions with and without the availability of clinical data.…”

Section: Kidneymentioning

confidence: 98%

Contrast-enhanced ultrasound: The evolving applications

Xu¹

2009

WJR

View full text Add to dashboard Cite

Contrast-enhanced ultrasound (CEUS) is a major breakthrough for ultrasound imaging in recent years. By using a microbubble contrast agent and contrast-specific imaging software, CEUS is able to depict the microand macro-circulation of the targeted organ, which in turn leads to improved performance in diagnosis. Due to the special dual blood supply system in the liver, CEUS is particularly suitable for liver imaging. It is evident that CEUS facilitates improvement for characterization of focal liver lesions (FLLs), detection of liver malignancy, guidance for interventional procedures, and evaluation of treatment response after local therapies. CEUS has been demonstrated to be equal to contrast-enhanced computed tomography or magnetic resonance imaging for the characterization of FLLs. In addition, the applicability of CEUS has expanded to non-liver structures such as gallbladder, bile duct, pancreas, kidney, spleen, breast, thyroid, and prostate. The usefulness of CEUS in these applications is confirmed by extensive literature production. Novel applications include detecting bleeding sites and hematomas in patients with abdominal trauma, guiding percutaneous injection therapy and therefore achieving the goal of using interventional ultrasonography in managing splenic trauma, assessing the activity of Crohn's disease, and detecting suspected endoleaks after endovascular abdominal aneurysm repair. Contrast-enhanced intraoperative ultrasound (US) and intracavitary use of CEUS have been developed and clinically studied. The potential use of CEUS involves sentinel lymph node detection, drug or gene delivery, and molecular imaging. In conclusion, the advent of CEUS has greatly enhanced the usefulness of US and even changed the status of US in clinical practice. The application of CEUS in the clinic is continuously evolving and it is expected that its use will be expanded further in the future.

show abstract

Differentiation of Benign From Malignant Focal Splenic Lesions Using Sulfur Hexafluoride–Filled Microbubble Contrast-Enhanced Pulse-Inversion Sonography

Abstract: Sulfur hexafluoride-filled microbubble-enhanced sonography improves characterization of focal splenic lesions with and without the availability of clinical data.

Cited by 55 publications

References 37 publications

Littoral Cell Angioma of the Spleen

Littoral Cell Angioma of the Spleen

Contribution of contrast enhanced sonography in the etiological diagnosis of focal splenic lesions

Contrast-enhanced ultrasound: The evolving applications

Contact Info

Product

Resources

About