Differentiation between malignant and benign thyroid nodules and stratification of papillary thyroid cancer with aggressive histological features: Whole-lesion diffusion-weighted imaging histogram analysis

Abstract

Whole-lesion ADC histogram analysis might help to differentiate malignant nodules from benign ones and show the PTCs with extrathyroidal extension. J. Magn. Reson. Imaging 2016;44:1546-1555.

Diffusion‐weighted quantitative MRI of pleural abnormalities: Intra‐ and interobserver variability in the apparent diffusion coefficient measurements

“…Similar results were reported by Ohno et al, who found better performance of ADC compared to maximum standardized uptake value obtained from PET‐CT as a quantitative predictor of tumor treatment response after chemoradiotherapy in nonsmall‐cell lung cancer . However, the aim of our study was to assess the repeatability of different protocols of ADC measurement that are generally used in other organs and compartments . Thus, the best method of ADC measurement for clinical application in DW‐MRI of the pleura and its benefit in evaluating and predicting treatment response are yet to be determined by means of further studies.…”

“…45 However, the aim of our study was to assess the repeatability of different protocols of ADC measurement that are generally used in other organs and compartments. [9][10][11]14,[16][17][18][19][20][21][32][33][34] Thus, the best method of ADC measurement for clinical application in DW-MRI of the pleura and its benefit in evaluating and predicting treatment response are yet to be determined by means of further studies. Lastly, in our study the CoV, which represents the ratio of the standard deviation to the mean, could be higher in MSR and OSR methods compared to the other measurement protocols because of the lower mean ADC value of the MSR and OSR methods.…”

“…DW‐MRI provides quantitative data that are generally obtained, in the clinical setting, through the measurement of the apparent diffusion coefficient (ADC) . Several studies have shown the ability of quantitative DW‐MRI to characterize benign and malignant disease in different organs and compartments . However, several factors, which include also the manual method of region‐of‐interest (ROI) positioning for measuring the ADC, affect the measurement and can lead to unreliable values .…”

“…disease in different organs and compartments. [6][7][8][9][10][11] However, several factors, which include also the manual method of region-of-interest (ROI) positioning for measuring the ADC, affect the measurement and can lead to unreliable values. 2,3,[12][13][14][15][16][17][18][19] Indeed, some investigators have found significant differences in ADC values by using different ROI methods in the same tumor, suggesting that the method of measurement significantly affects the ADC.…”

Histogram Analysis of Diffusion Weighted Imaging at 3T is Useful for Prediction of Lymphatic Metastatic Spread, Proliferative Activity, and Cellularity in Thyroid Cancer

“…To the best of the authors’ knowledge, only one study used ADC histogram analysis in thyroid cancer to differentiate benign from malignant nodules and furthermore reveal extra-thyroidal growth of papillary thyroid cancer [18]. So far, no studies demonstrated predictability of lymph node involvement by ADC histogram analysis of the primary tumor.…”