Improving lymph node characterization in staging malignant lymphoma using first‐order ADC texture analysis from whole‐body diffusion‐weighted MRI

Paepe, Katja N. De; Keyzer, Frederik De; Wolter, Pascal; Bechter, Oliver; Dierickx, Daan; Janssens, Ann; Verhoef, Gregor; Oyen, Raymond; Vandecaveye, Vincent

doi:10.1002/jmri.26034

Cited by 19 publications

(7 citation statements)

References 43 publications

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“…Among the potential perspectives of the use of whole-body MRI to image patients with lymphoma, new and interesting fields of application include the computer assisted diagnosis, the texture analysis and the radiomics [55][56][57][58][59]. Several authors proposed the use of CAD to improve the lesion (damage) segmentation and the ADC value calculation in other tumors [55].…”

Section: Future Perspectivesmentioning

confidence: 99%

“…Texture analysis can be used to assess the spatial pattern and arrangement of pixel intensities in images to detect thetumoral heterogeneity, which several authors have shown, to have non-negligible correlations with tumor behavior, prognosis and response to treatment. In this setting, a relatively recent work by De Paepe et al has shown that the first order texture analysis of the ADC values improves the diagnostic performance of DWI in the characterization of locations of lymphoma if compared to the simple ADC average value calculation [58]. Similarly, a recent interesting paper on the texture analysis of post contrast T1 weighted images reported the high diagnostic performance in differentiating follicular from DLBCL that can be a valuable tool to identify the aggressive transformation of i-NHL [59].…”

Section: Future Perspectivesmentioning

confidence: 99%

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Whole-Body Magnetic Resonance Imaging: Current Role in Patients with Lymphoma

et al. 2021

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Imaging of lymphoma is based on the use of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) and/or contrast-enhanced CT, but concerns have been raised regarding radiation exposure related to imaging scans in patients with cancer, and its association with increased risk of secondary tumors in patients with lymphoma has been established. To date, lymphoproliferative disorders are among the most common indications to perform whole-body magnetic resonance imaging (MRI). Whole-body MRI is superior to contrast-enhanced CT for staging the disease, also being less dependent on histology if compared to 18F-FDG-PET/CT. As well, it does not require exposure to ionizing radiation and could be used for the surveillance of lymphoma. The current role of whole-body MRI in the diagnostic workup in lymphoma is examined in the present review along with the diagnostic performance in staging, response assessment and surveillance of different lymphoma subtypes.

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Section: Future Perspectivesmentioning

confidence: 99%

Section: Future Perspectivesmentioning

confidence: 99%

Whole-Body Magnetic Resonance Imaging: Current Role in Patients with Lymphoma

et al. 2021

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“…In this study, we did not analyze or compare quantitative ADC values related to DWI because there are currently no validated single cut-off values to differentiate positive from negative lymph nodes, although lower values have been positively correlated with malignancy, whereas higher values indicate normal histology [25,30]. Future comparative studies between SUV max and ADC values could clarify the correlation (that we expect to be negative or inverse) between the quantitative data offered by these two imaging modalities in the characterization of malignant lymph nodes [31].…”

Section: Discussionmentioning

confidence: 99%

MRI versus CT and PET/CT in the Preoperative Assessment of Hodgkin and Non-Hodgkin Lymphomas

Maccioni

Calabrese

Manganaro

et al. 2021

Hemato

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(1) Background: The purpose of this study is to retrospectively compare CT, MRI, and PET/CT in detecting lymphadenopathies and extra-nodal lesions in lymphoma and in disease staging. (2) Methods: Inclusion criteria were the availability of TB (Total Body) CT and/or PET/CT performed before treatment; MRI performed no later than 2 weeks after TBCT; histological confirmation of lymphoma; clinical-diagnostic follow-up. Using these criteria, we included 64/353 patients with TBCT and MRI performed at our hospital; 20/64 had PET/CT performed in other hospitals. Histology and follow-up were gold standard. (3) Results: The sensitivity, specificity, and accuracy in lymph nodes detection was 84.5%, 94.4%, and 91% for CT and 95%, 98.9%, and 95.6% for MRI. High agreement was observed between CT and MRI regarding the number and size of positive lymph nodes and for disease staging. MRI identified eight more extra-nodal lesions than CT. In the subgroup of 20 patients, PET/CT did not show a significant superiority in sensitivity, specificity, accuracy, and staging ability than CT and MRI. (4) Conclusions: Our study demonstrates a mild superiority of MRI over CT in lymphoma staging. Although PET/CT remains the reference standard, MRI demonstrated a similar diagnostic accuracy, with the added value of being radiation-free.

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“…K. de Paepe с соавт. [13] обследовали пациентов с НХЛ и пришли к аналогичному выводу -ИКД пораженных ЛУ средостения и брюшной полости выше, чем ИКД ЛУ других анатомических областей, что авторы объясняют эффектом частичного объема и двигательными артефактами, связанными с дыханием и перистальтикой кишечника. D. Albano с соавт.…”

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“…Некоторые авторы указывают на отсутствие отличий между значениями ИКД при ЛХ и НХЛ[9], агрессивных и индолентных НХЛ[7], другими авторами получены противоположные результаты[12]. Эти расхождения могут быть связаны с влиянием на значения ИКД ряда клинических и технических факторов, что изучено недостаточно[13][14][15].Во многих работах исследована диагностическая эффективность МРТ-ДВИ всего тела по сравнению с позитронной эмиссионной томографией, комбинированной с компьютерной томографией (ПЭТ/КТ)[3, 6,14]. При интерпретации ПЭТ/КТ для дифференциации нормальных тканей и опухолевых очагов используют количественный показатель уровня метаболизма глюкозы -стандартизованный показатель накопления.…”

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Magnetic resonance imaging apparent diffusion coefficient in lymphomas and its dependence on a number of technical and clinical factors

Kharuzhyk

Karman

Zhavrid

2022

Vescì Nac. akad. navuk Belarusì, Ser. med. navuk

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The purpose of this study was to determine the value of apparent diffusion coefficient (ADC) in various morphological variants of lymphomas, to study dependence of ADC on the anatomical location of lesions and technical scanning parameters to establish the usefulness in differentiating normal and involved lymph nodes (LN).Whole body MRI with diffusion-weighted imaging (DWI) was performed in 209 patients with lymphoma before treatment. A target LN was selected and ADC determined in each patient.The ADC value does not depend on the use of the parallel imaging technique (p = 0.56), higher when using built-in compared to superficial coil (p < 0.0001), higher when using respiratory triggering than free breathing (p < 0.02). The highest ADC values (х10-3 mm2/s) were obtained in the involved LN of the lung hilar (1.429 ± 0.396) and mediastinum (1.338 ± 0.313), lower values (p < 0.01) - in the LN of the abdomen (1.011 ± 0.298), axillary (0.840 ± 0.196), neck (0.834 ± 0.259), inguinal (0.753 ± 0.128) and iliac (0.738 ± 0.129). Depending on the morphological variant of lymphoma, the highest ADC value was obtained in Hodgkin lymphoma - 1.168 ± 0.372 (p < 0.0002). ADC in diffuse large B-cell non-Hodgkin lymphoma was 0.951 ± 0.320, indolent non-Hodgkin lymphomas - 0.756 ± 0.246, mantle zone non-Hodgkin lymphoma - 0.759 ± 0.211.In conclusion, DWI in lymphoma should be performed using surface coil, parallel imaging, and free breathing. Statistically significant differences in ADC were found depending on the anatomical location of the lesions and the morphological variant of lymphoma. Given the dependence of ADC on various technical and clinical factors, it is not possible to establish a single threshold value for differentiating involved and normal LN. The use of the LN size criterion for this purpose is the most optimal in lymphoma.

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Improving lymph node characterization in staging malignant lymphoma using first‐order ADC texture analysis from whole‐body diffusion‐weighted MRI

Abstract: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;48:897-906.

Cited by 19 publications

References 43 publications

Whole-Body Magnetic Resonance Imaging: Current Role in Patients with Lymphoma

Whole-Body Magnetic Resonance Imaging: Current Role in Patients with Lymphoma

MRI versus CT and PET/CT in the Preoperative Assessment of Hodgkin and Non-Hodgkin Lymphomas

Magnetic resonance imaging apparent diffusion coefficient in lymphomas and its dependence on a number of technical and clinical factors

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