Differentiation between benign and malignant palatal tumors using conventional MRI: a retrospective analysis of 130 cases

Zheng, Yingyan; Xiao, Zhang; Zhang, Hua; She, Dejun; Lin, Xiangtao; Lin, Yu; Cao, Dairong

doi:10.1016/j.oooo.2018.01.006

Cited by 19 publications

(11 citation statements)

References 26 publications

(36 reference statements)

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“…Low-grade malignant tumors have a generally benign appearance, but microcysts or irregular cystic spaces, hemorrhagic or necrosis are occasionally observed on CT and MR images. High-grade malignant tumors show poorly delated margin, invasion to adjacent structure (nasal cavity, maxillary sinuses) and perineural spread (5). In MR imaging of the MCXPA presented here, the lesion appeared as a lobulated, heterogeneous enhancing mass with internal fluid-hemorrhage level and a necrotic portion, suggesting a malignant tumor.…”

Section: Discussionmentioning

confidence: 66%

“…Myoepithelial carcinoma ex pleomorphic adenoma (MCXPA), defined as MC with malignant transformation in a pleomorphic adenoma, is extremely rare. Recently, there have been several reports of CT or MRI findings for tumors of the palate (4,5). However, so far no reports have been made regarding the MRI features of the MCXPA arising at the palate.…”

Section: Introductionmentioning

confidence: 99%

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MR Imaging Characteristics of Myoepithelial Carcinoma Ex Pleomorphic Adenoma of the Palate: Rare Case Report

Jeon

Kim

et al. 2019

Iran J Radiol

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Carcinoma ex pleomorphic adenoma is an uncommon tumor of salivary gland; moreover, myoepithelial carcinoma of palate is exceedingly rare. This report documents a case of carcinoma ex pleomorphic adenoma arising in the hard palate. A 51-year-old woman presented with foreign body sensation without pain. Preoperative biopsy was performed and resulted in pleomorphic adenoma of the hard palate. MR imaging findings were well circumscribed, dome-shaped, lobulated mass with hyposignal intensity at peripheral fibrous capsule on T2WI. The mass showed internal cyst, hemorrhage, necrosis and heterogeneous enhancement. Because it showed both benign and malignant findings, the radiologic diagnosis was likely to be a malignant tumor of palate. Postoperative pathological analysis revealed invasive myoepithelial carcinoma ex pleomorphic adenoma.

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Section: Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

MR Imaging Characteristics of Myoepithelial Carcinoma Ex Pleomorphic Adenoma of the Palate: Rare Case Report

Jeon

Kim

et al. 2019

Iran J Radiol

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“…However, in addition to visual inspection, the diagnosis of oral SGTs depends on histopathological examination. Although some approaches have been proposed as an aid to detect SGTs, disadvantages exist in the diagnosis, such as low resolution and invasive [3,8,47].…”

Section: Discussionmentioning

confidence: 99%

“…To assist the clinician and improve accuracy, some auxiliary diagnostic methods, such as fluorescence [6], ultrasonography [7], and magnetic resonance imaging [8], have been studied in the oral cavity. However, they exist some limitations, such as resolution, imaging contrast, or portability.…”

Section: Introductionmentioning

confidence: 99%

Classification of Salivary Gland Tumors Based on Quantitative Optical Coherence Tomography

et al. 2021

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Background and Objectives Visual inspection is the primary diagnostic method for oral diseases, and its accuracy of diagnosis mainly depends on surgeons’ experience. Histological examination is still the golden standard, but it is invasive and time‐consuming. In order to address these issues, as a noninvasive imaging technique, optical coherence tomography (OCT) can differentiate oral tissue with advantages of real‐time, in situ, and high resolution. The aim of this study is to explore optimal quantitative parameters in OCT images to distinguish different salivary gland tumors. Study Design/Materials and Methods OCT images of four salivary gland tumors were obtained from 14 patients, including mucoepidermoid carcinoma (MC), adenoid cystic carcinoma (ACC), basal cell adenoma (BCA), and pleomorphic adenoma (PA). Two parameters of optical attenuation coefficient (OAC) and standard deviation (SD) along the depth of OCT signal were combined to create a computational model of classification, and sensitivity/specificity of classification was calculated statistically to evaluate their results. Results A total of 5,919 two‐dimensional (2D) OCT images were used for quantitative analysis. The classification sensitivities of 89.6%, 95.0%, 89.5%, 97.8%, and specificities of 97.6%, 99.0%, 98.0%, 98.2%, respectively, were obtained for MC, ACC, BCA, and PA, with the thresholds of 3.6 mm−1 based on OAC and 0.22/0.18 based on SD. Conclusion It was demonstrated that OAC and SD could be considered as important parameters in quantitative analysis of OCT images for salivary gland tissue characterization and intraoperative diagnosis. It is of great potential value in promoting the application of this method based on OCT in clinical practice. Lasers Surg. © 2020 Wiley Periodicals LLC

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“…Benign salivary gland neoplasms are most common than malignant . On the other hand, the clinical appearance of malignant and benignant salivary gland neoplasms is very similar, specifically in the hard palate . It is necessary to highlight that MSGT presents different phenotypic characteristics and various clinical outcomes .…”

Section: Introductionmentioning

confidence: 99%

High levels of ANXA2 are characteristic of malignant salivary gland tumors

Cardoso

Jesus

Souza

et al. 2019

J Oral Pathology Medicine

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Objective Malignant salivary gland tumors (MSGTs) present different phenotypic characteristics and various clinical outcomes, which proved to be a diagnostic challenge. Considering the heterogeneity of MSGT, this study aims to identify molecule related to the nature of MSGT. Methods For screening, proteomic analysis comparing MSGT with pleomorphic adenoma (PA) and salivary gland was performed. The MSGT‐associated protein which presented in the higher number in the Gene Expression Omnibus (GEO) database was selected. To validate the data, immunohistochemistry (IHC) was performed in 14 patients with PA, 22 patients with MSGT, and 14 controls. Results 16 proteins were associated with MSGT. ANXA2 was the primary protein, according to GEO database analyses. ANXA2 was most expressed in the cell membrane. However, some ANXA2 staining was also observed in the cytoplasm and nucleus. ANXA2 was highly expressed in MSGT in comparison with control. Also, ANXA2 has a higher expression in adenocarcinoma not otherwise specified (ANOS) and myoepithelial carcinoma (MC) in comparison with PA. Conclusion In conclusion, this study demonstrated that MSGT presented higher levels of ANXA2 in comparison with normal salivary glands. Also, ANXA2 might be interesting as a molecular marker of ANOS and MS.

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Differentiation between benign and malignant palatal tumors using conventional MRI: a retrospective analysis of 130 cases

Abstract: Conventional magnetic resonance imaging is useful for differentiating benign from malignant palatal tumors as well as benign salivary gland tumors from low-grade salivary gland malignancies.

Cited by 19 publications

References 26 publications

MR Imaging Characteristics of Myoepithelial Carcinoma Ex Pleomorphic Adenoma of the Palate: Rare Case Report

MR Imaging Characteristics of Myoepithelial Carcinoma Ex Pleomorphic Adenoma of the Palate: Rare Case Report

Classification of Salivary Gland Tumors Based on Quantitative Optical Coherence Tomography

High levels of ANXA2 are characteristic of malignant salivary gland tumors

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