Differentiation between Benign and Malignant Adrenal Mass using Contrast-Enhanced Ultrasound

Friedrich‐Rust, Mireen; Glasemann, T.; Polta, A.; Eichler, Katrin; Holzer, Katharina; Kriener, Susanne; Herrmann, Eva; Nierhoff, J.; Bon, D.; Bechstein, Wolf O.; Vogl, Thomas J.; Zeuzem, Stefan; Bojunga, Joerg

doi:10.1055/s-0031-1273408

Cited by 39 publications

(50 citation statements)

References 12 publications

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“…In general, the combination of these morphological imaging methods provides sufficient information about the nature and extension of the lesion allowing a correct diagnosis of neck PGL [17] without submitting the patient to cytologic analysis which does often not provide additional information, may lead to vascular complications and diagnostic errors [22]. The role of contrast enhanced US (CEUS) in the initial diagnosis and classification of malignant masses requires further testing [23].…”

Section: Discussionmentioning

confidence: 99%

Role of ultrasound and color Doppler imaging in the detection of carotid paragangliomas

Demattè

Sarra

Schiavi³

et al. 2012

Journal of Ultrasound

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KEYWORDSCarotid body paraganglioma; Carotid-body tumor; Ultrasound; Color Doppler ultrasound.Abstract Introduction: Carotid body paragangliomas (PGLs) are highly vascularized lesions that arise from the paraganglia located at the carotid bifurcation. Purpose: To evaluate the usefulness of gray-scale ultrasound (US) and color Doppler ultrasound (CDUS) in the detection and follow-up of carotid PGLs of the neck. Materials and methods: The authors retrospectively reviewed US and CDUS examinations of the neck performed in 40 patients with PGL syndrome type 1 and single or bilateral neck PGLs confirmed by CT or MRI; the patients had a total of 60 PGLs of the neck. US and CDUS outcome was compared to the outcome of second-line imaging techniques such as magnetic resonance imaging (MRI) or computed tomography (CT). The following findings were considered: presence/absence of focal lesions at US imaging and difference in maximum diameter of the lesion measured at US and MRI/CT. Results were compared using the Student's t-test. Results: Of the 60 PGLs of the neck only 5 (8.3%) were not visualized at US or CDUS examination. The difference in maximum diameter of these lesions measured at CT/MRI and US/CDUS ranged between À5 mm and þ16 mm (mean difference 2.2 AE 6.0). This difference was statistically significant (p Z 0.008). Conclusions: US and CDUS are useful methods for identifying carotid PGLs also measuring less than 10 mm in diameter. However, diagnostic accuracy of US and CDUS is reduced in the measurement of the exact dimensions of the lesions.Sommario Introduzione: I paragangliomi (PGLs) carotidei sono lesioni altamente vascolarizzate che originano dai paragangli localizzati a livello della biforcazione carotidea. Scopo: Valutare l'utilità dell'ecografia (US) e dell'Eco color Doppler (USD) del collo nella diagnosi e nel follow-up dei PGLs carotidei. Materiali e metodi: Abbiamo visionato retrospettivamente tutte le US e gli USD del collo, eseguiti nell'Ospedale Santa Chiara di Trento tra il 2007 e il 2011, di soggetti affetti da sindrome paraganglioma di tipo 1 con sicuri paragangliomi del collo singoli o bilaterali. Abbiamo quindi confrontato i risultati con quelli di metodiche di imaging di secondo livello, Risonanza Magnetica (RM) o Tomografia Computerizzata (TC). Sono stati calcolati i casi discordanti in termini di presenza/assenza della lesione focale alle immagini ecografiche e in termini di differenze del diametro maggiore rilevate tra le due metodiche. Risultati: Sono stati revisionati i dati di imaging (US e/o USD, RM o TC) eseguiti tra il 2007 e il 2011 di 40 pazienti aventi 60 sicuri paragangliomi del collo. Di questi solo 5/60 (8,3%) non sono stati visualizzati mediante US e/o USD. La differenza nella misura del diametro maggiore di tali lesioni rilevate dalle due tecniche di imaging, è risultata compresa tra -5 e þ16 mm (media di 2,2 AE 6,0). Tale differenza è risultata statisticamente significativa (p Z 0,008) (test-Student). Conclusioni: L'US e l'USD del collo risultano metodiche di imaging utili nell'...

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Section: Discussionmentioning

confidence: 99%

Role of ultrasound and color Doppler imaging in the detection of carotid paragangliomas

Demattè

Sarra

Schiavi³

et al. 2012

Journal of Ultrasound

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“…The use of contrast-enhanced ultrasound has shown an excellent sensitivity and specificity in the differential diagnosis between benign and malignant adrenal mass [78] ; however, no experiences of adrenal oncocytic neoplasm has been described. 18 F-FDG whole-body positron emulsion tomography is utilized to differentiate benign from malignant nonfunctioning adrenal masses; in the literature there are only a few published reports about findings in adrenocortical oncocytoma by this method [79] , and the findings are contradictory [80,81] .…”

Section: Diagnosismentioning

confidence: 99%

Adrenal Oncocytic Neoplasm: A Systematic Review

Mearini¹,

Sordo

Costantini³

et al. 2012

Urol Int

151

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Introduction: Oncocytic neoplasms as tumors arising in the adrenal glands are rare, usually considered as nonfunctional and benign. In the current literature, there are extremely limited reports of adrenal oncocytic neoplasms; as to date, only 147 cases have been described. The rarity of the event prompted this study which reviews and presents the incidence, histology, diagnosis and therapy of adrenal oncocytic neoplasms. Materials and Methods: A review by systematic literature search was done using the MEDLINE®/Cochrane libraries from 1950 to date using the medical subject headings ‘oncocytoma', ‘adrenal gland', ‘adrenal oncocytoma', ‘adrenal oncocytic neoplasm' and ‘adrenal oncocytic carcinoma'. Results: Adrenal oncocytic neoplasm is a rare disease, usually incidentally detected because only 17% are functional adrenal masses. The typical oncocyte displays abundant granular eosinophilic cytoplasm, due to the accumulation of mitochondria. Computed tomography and magnetic resonance imaging are not able to identify or differentiate benign and malignant oncocytic neoplasms. The mainstay of therapy is adrenalectomy, recently performed by laparoscopy. The prognosis is good for benign tumors, while adrenocortical oncocytic carcinoma has a poor survival rate of only 5 years. Conclusions: Adrenal oncocytic neoplasm, a rare and mostly benign tumor, usually presents as an incidental, large adrenal mass; surgery is the mainstay of therapy, by means of laparoscopy which is now the most diffuse approach to adrenalectomy.

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“…The study by Dietrich et al indicated ineptitude to distinguish malignant and benign lesions [6]. On the contrary Friedrich-Rust at al suggested that contrast-enhanced ultrasound may be a useful method in diagnostic work-up of adrenal mass with excellent sensitivity for the diagnosing of malignancy [7]. They established 4 patterns based on times to first contrast enhancement: I = early arterial contrast enhancement (<20 s), II = arterial contrast enhancement beginning in the arterial phase (21-40 s), III = late and little contrast enhancement in the late phase (>40 s), and IV = no recordable contrast enhancement at all.…”

Section: Discussionmentioning

confidence: 99%

“…Recently some new ultrasound modalities have been investigated in regard to adrenal masses differentiation (malignant vs. benign) [6][7][8][9] or within benign group of adrenal masses [10].…”

Section: Introductionmentioning

confidence: 99%

Application of parametric ultrasound contrast agent perfusion studies for differentiation of hyperplastic adrenal nodules from adenomas—Initial study

Słapa

Kasperlik-Załuska²,

Migda

et al. 2015

European Journal of Radiology

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Differentiation between Benign and Malignant Adrenal Mass using Contrast-Enhanced Ultrasound

Abstract: Contrast-enhanced ultrasound may be a useful method in the diagnostic work-up of adrenal mass with excellent sensitivity for the diagnosis of malignancy.

Cited by 39 publications

References 12 publications

Role of ultrasound and color Doppler imaging in the detection of carotid paragangliomas

Role of ultrasound and color Doppler imaging in the detection of carotid paragangliomas

Adrenal Oncocytic Neoplasm: A Systematic Review

Application of parametric ultrasound contrast agent perfusion studies for differentiation of hyperplastic adrenal nodules from adenomas—Initial study

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