Application of parametric ultrasound contrast agent perfusion studies for differentiation of hyperplastic adrenal nodules from adenomas—Initial study

Słapa, Rafał Z.; Kasperlik-Załuska, A; Migda, Bartosz; Otto, Maciej; Jakubowski, W

doi:10.1016/j.ejrad.2015.05.006

Cited by 9 publications

(9 citation statements)

References 12 publications

(11 reference statements)

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“…The question of differentiating between nodular hyperplasias of the adrenal cortex and adenomas is often missing from papers on diagnostic imaging of adrenal masses. It turned out to have a better sensitivity and specificity, than with the parameter of echogenicity, of 100% and 83%, respectively, based on the assessment of the inflow dynamics pattern of a third-generation ultrasound contrast agent (SonoVue) with parametric images ( 9 ) .…”

Section: Discussionmentioning

confidence: 99%

Echogenicity of benign adrenal focal lesions on imaging with new ultrasound techniques – report with pictorial presentation

et al. 2015

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AimThe aim of the research was to assess the echogenicity of benign adrenal focal lesions using new ultrasound techniques.Material and method34 benign adrenal masses in 29 patients were analyzed retrospectively. The examinations were conducted using Aplio XG (Toshiba, Japan) ultrasound scanner with a convex probe 1–6 MHz in the B-mode presentation with the combined use of new ultrasound techniques: harmonic imaging and spatial compound sonography. The size of the adrenal tumors, their echogenicity and homogeneity were analyzed. Statistical analysis was conducted using the STATISTICA 10 software.ResultsThe following adrenal masses were assessed: 12 adenomas, 10 nodular hyperplasias of adrenal cortex, 7 myelolipomas, 3 pheochromocytomas, a hemangioma with hemorrhage and a cyst. The mean diameter of nodular hyperplasia of adrenal cortex was not statistically different from that of adenomas (p = 0.075). The possibility of differentiating between nodular hyperplasia and adenoma using the parameter of hypoechogenicity or homogeneity of the lesion was demonstrated with the sensitivity and specificity of 100% and 41.7%, respectively. The larger the benign adrenal tumor was, the more frequently did it turn out to have a mixed and inhomogenous echogenicity (p < 0.05; ROC areas under the curve: 0.832 and 0.805, respectively).ConclusionsA variety of echogenicity patterns of benign adrenal focal lesions was demonstrated. The image of an adrenal tumor correlates with its size. The ultrasound examination, apart from its indisputable usefulness in detecting and monitoring adrenal tumors, may also allow for the differentiation between benign lesions. However, for lesions found incidentally an algorithm for the assessment of adrenal incidentalomas is applicable, which includes computed tomography and magnetic resonance imaging.

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Section: Discussionmentioning

confidence: 99%

Echogenicity of benign adrenal focal lesions on imaging with new ultrasound techniques – report with pictorial presentation

et al. 2015

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“…No CEUS criteria can reliably differentiate between benign and malignant adrenal gland tumors, with conflicting reports [119 -121]. Dynamic CEUS using time-intensity curve analysis has been deployed in the investigation of adrenal gland tumors without clear differentiation [120,122]. CEUS may demonstrate characteristic hypervascularity of some adrenal gland tumors, e. g., pheochromocytoma, which typically also have necrotic regions with no contrast enhancement [121,123,124].…”

Section: Adrenal Glandsmentioning

confidence: 99%

The EFSUMB Guidelines and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound (CEUS) in Non-Hepatic Applications: Update 2017 (Long Version)

et al. 2018

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“…12 Several quantitative DCEUS techniques are currently developed on the specific software platform to directly depict and quantify the microvascular hemodynamic characterizations. [13][14][15][16][17][18][19][20] Rognin et al proposed the quantitative classification method based on the contrast-enhanced time-intensity curves (TIC) to characterize the differentiation between benign and malignant focal lesions. 19 According to the modulation of various perfusion parameters estimated from DCEUS loops in focal lesions, Gu 5 and Greis 13 et al developed a novel multiparametric perfusion functional imaging (PFI) technique to respectively quantify the renal and hepatic microvascular hemodynamic distributions.…”

Section: Introductionmentioning

confidence: 99%

A fast scheme for renal microvascular perfusion functional imaging: Assessed by an imaging quality evaluation model

Wang

Xu²,

Zhang

et al. 2019

Medical Physics

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Purpose This study aimed to develop a fast scheme of multiparametric perfusion functional imaging (PFI) based on dynamic contrast‐enhanced ultrasound (DCEUS) for assessing renal microvascular hemodynamics. Method The flow process in the DCEUS‐based PFI was modified step‐by‐step to improve its operational efficiency, which was validated through in vivo renal perfusion experiments. A multiparametric model with a comprehensive coefficient of imaging quality (CIQ) was then built on four terms of the average information entropy, contrast, gray, and noise coefficient of PFIs to evaluate the sacrifice of imaging quality during modifications of DCEUS‐based PFI. Results The multiparametric model successfully evaluated modifications of DCEUS‐based PFI from multiple perspectives (R2 = 0.73, P < 0.01). Compared with the raw scheme in the renal sagittal and coronal planes, the fast PFI scheme significantly improved its operational efficiency by 62.82 ± 1.07% (P < 0.01) and the nine PFIs simultaneously maintained a similar CIQ of 0.26 ± 0.06. Conclusions The inhomogeneous hemodynamic distributions with a ring‐like feature in the renal microvasculature were accurately and efficiently characterized by the fast PFI scheme. The fast PFI scheme can be applied for early diagnosis, follow‐up evaluation and monitoring treatment of chronic kidney disease.

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Application of parametric ultrasound contrast agent perfusion studies for differentiation of hyperplastic adrenal nodules from adenomas—Initial study

Cited by 9 publications

References 12 publications

Echogenicity of benign adrenal focal lesions on imaging with new ultrasound techniques – report with pictorial presentation

Echogenicity of benign adrenal focal lesions on imaging with new ultrasound techniques – report with pictorial presentation

The EFSUMB Guidelines and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound (CEUS) in Non-Hepatic Applications: Update 2017 (Long Version)

A fast scheme for renal microvascular perfusion functional imaging: Assessed by an imaging quality evaluation model

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