Differentiation and diagnosis of benign and malignant testicular lesions using 18F-FDG PET/CT

Shao, Dan; Gao, Qiang; Tian, Xu-Wei; Wang, Siyun; Liang, Changhong; Wang, Shuxia

doi:10.1016/j.ejrad.2017.05.001

Cited by 16 publications

(12 citation statements)

References 23 publications

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“…A study involving 203 men has demonstrated that the normal SUV range from 1.23 to 3.85 with a mean value of 2.44 [ 23 ]. In addition, previous study including 53 patients has reported that a SUV max of 3.75 is the optimal cut-off value for differentiating between benign and malignant testicular diseases [ 24 ]. As for the testicular lesions of our population, the mean SUV max was 11.09, with a range of 7.20 to 19.75.…”

Section: Discussionmentioning

confidence: 99%

Functional Parameters of ¹⁸F-FDG PET/CT in Patients with Primary Testicular Diffuse Large B-Cell Lymphoma

Yang

Zhu

Pang

et al. 2018

Contrast Media & Molecular Imaging

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Fluorine-18 fluorodeoxyglucose (18F-FDG) positron-emission tomography/computed tomography (PET/CT), a hybrid imaging technique that simultaneously provides functional and anatomical information, has been reported to be useful in lymphoma. The present study was to evaluate the functional parameters of 18F-FDG PET/CT in patients with testicular diffuse large B-cell lymphoma (DLBCL). We retrospectively reviewed medical records of 5095 patients with lymphoma who treated at West China Hospital between March 2003 and January 2017, and selected patients with 18F-FDG PET/CT findings and subsequently biopsy confirmed the invasion of testis with DLBCL. Maximum standardized uptake values (SUVmax), peak standardized uptake values (SUVpeak), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the patients were measured. We evaluated the characteristics of 18F-FDG PET/CT in this population. Six patients ranged in age from 37 to 73 years (median age, 58 years) were included in the analysis. The mean SUVmax was 11.09 and varied between 7.20 and 19.75; mean SUVpeak was 9.56 and ranged between 6.79 and 14.39. In addition, mean MTV 42% was 18.4 and varied between 1.3 and 61.6; mean MTV 2.5 was 34.7 and varied significantly between 1.6 and 141.9. With regard to TLG, mean TLG 42% was 168.906 and ranged from 7.514 to 687.004, while mean TLG 2.5 was 253.972 and ranged from 8.400 to 1127.802. In conclusion, 18F-FDG PET/CT scan is a useful tool in patients with testicular DLBCL. SUV, MTV, and TLG may vary a lot in different patients. SUVmax of testicular DLBCL lesion is relatively higher than that of normal testis. Also, we provided a set of MTV and TLG data and firstly showed their significant correlation with overall survival, which indicated a potential prognostic value of MTV and TLG. However, studies with larger population are needed to confirm these findings.

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Section: Discussionmentioning

confidence: 99%

Functional Parameters of ¹⁸F-FDG PET/CT in Patients with Primary Testicular Diffuse Large B-Cell Lymphoma

Yang

Zhu

Pang

et al. 2018

Contrast Media & Molecular Imaging

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“…Because of this fact, FDG-PET can be used in clinical routine to aid in discrimination between benign and malignant lesions [5–7], might predict treatment response [8–10] and might also be able to reflect histopathology parameters of tumors [11, 12].…”

Section: Introductionmentioning

confidence: 99%

Associations between GLUT expression and SUV values derived from FDG-PET in different tumors—A systematic review and meta analysis

2019

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Purpose Fluorodeoxyglucose-Positron-emission tomography (FDG-PET), quantified by standardized uptake values (SUV), is one of the most used functional imaging modality in clinical routine. It is widely acknowledged to be strongly associated with Glucose-transporter family (GLUT)-expression in tumors, which mediates the glucose uptake into cells. The present systematic review sought to elucidate the association between GLUT 1 and 3 expression with SUV values in various tumors. Methods MEDLINE library was screened for associations between FDG-PET parameters and GLUT correlation cancer up to October 2018. Results There were 53 studies comprising 2291 patients involving GLUT 1 expression and 11 studies comprising 405 patients of GLUT 3 expression. The pooled correlation coefficient for GLUT 1 was r = 0.46 (95% CI 0.40–0.52), for GLUT 3 was r = 0.35 (95%CI 0.24–0.46). Thereafter, subgroup analyses were performed. The highest correlation coefficient for GLUT 1 was found in pancreatic cancer r = 0.60 (95%CI 0.46–0.75), the lowest was identified in colorectal cancer with r = 0.21 (95% CI -0.57–0.09). Conclusion An overall only moderate association was found between GLUT 1 expression and SUV values derived from FDG-PET. The correlation coefficient with GLUT 3 was weaker. Presumably, the underlying mechanisms of glucose hypermetabolism in tumors are more complex and not solely depended on the GLUT expression.

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“…[ 16 ] Mean testicular volume reported by Gupta et al ., Huang et al ., Fui MNT et al ., and Anafa et al . was 16.73 cm 3 ,[ 23 ] 16.57 cm 3 ,[ 25 ] 18.0 cm 3 ,[ 26 ] and 18.57 cm 3 ,[ 14 ] respectively. These values observed in studies done in Asia and Australia are similar to the values observed in the Indian population of our study.…”

Section: Discussionmentioning

confidence: 99%

“…[ 9 10 11 ] Hence, an understanding of the normal physiological variations in the distribution of FDG in testes is important for the proper interpretation of FDG-PET/CT scans. [ 12 13 14 ] There are few studies that have already evaluated the physiological FDG uptake in testes; however, no studies are there among the Indian population to the best of our knowledge. In this study, we have retrospectively analyzed the physiological FDG uptake in the apparently healthy testes, among the Indian population, who have undergone FDG PET/CT scans for various malignancies (excluding testicular malignancies).…”

Section: Introductionmentioning

confidence: 99%

Physiologic testicular uptake of 18-F fluorodeoxyglucose in the Indian population

et al. 2021

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Objective: The objective of the study is to assess the physiologic uptake of testes in patients undergoing 18 F-fluoro-2-deoxyglucose (FDG) position emission tomography/computed tomography (PET/CT) scans for various malignancies other than testicular malignancy. Materials and Methods: The testicular uptake of 18 F-FDG expressed as the standardized uptake value (T) was measured on PET/CT images in 320 men with no known testicular pathology from July 2019 to March 2020 at Tata Main Hospital, Jamshedpur. The ratio of maximum standardized uptake value (SUVmax) of the testis (T) to SUVmax of muscle (M) T/M ratio and to SUVmax of the liver (L) T/L ratio was calculated using SUVmax of right adductor muscle and liver, respectively. Testicular volume was calculated with the measurements taken from the axial, coronal, and sagittal slices of CT images. The correlation of testicular uptake with age, blood serum glucose level, and testicular volume was also analyzed. Results: The mean age of 320 men was 57 ± 15 years (range: 10–94) and the mean blood glucose level was 107.7 ± 23.5 mg/dl (range: 64–175). Mean testicular SUVmax in 320 men was 2.48 ± 0.80 (range: 0.67–5.5). The mean testicular volume of 640 testes of 320 men was 18.80 ± 4.83 cm 3 (range: 3.85–33.56 cm 3 ). The mean values of (T/M) and (T/L) ratios in the studied population were 3.64 ± 1.21 (range: 1.08–5.58) and 0.97 ± 0.251 (range: 0.34–1.88), respectively. The laterality index (L − R/(L + R) ×2) in 320 men was 0.074 ± 0.050 (0.000–0.308). There was a minimal negative correlation between testicular SUVmax and age ( r = −0.136, P = 0.15). Mild negative correlation was noted between T/M ratio and age ( r = −0.291, P < 0.0001) and between T/L ratio and age ( r = −0.182, P = 0.001) in the studied population. Conclusion: The physiological testicular FDG uptake (SUVmax) of testes was 2.48 ± 0.80 (0.67–5.5) among the Indian population in this study, which has a mild negative correlation with age.

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Differentiation and diagnosis of benign and malignant testicular lesions using 18F-FDG PET/CT

Cited by 16 publications

References 23 publications

Functional Parameters of ¹⁸F-FDG PET/CT in Patients with Primary Testicular Diffuse Large B-Cell Lymphoma

Functional Parameters of ¹⁸F-FDG PET/CT in Patients with Primary Testicular Diffuse Large B-Cell Lymphoma

Associations between GLUT expression and SUV values derived from FDG-PET in different tumors—A systematic review and meta analysis

Physiologic testicular uptake of 18-F fluorodeoxyglucose in the Indian population

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Differentiation and diagnosis of benign and malignant testicular lesions using 18F-FDG PET/CT

Cited by 16 publications

References 23 publications

Functional Parameters of 18F-FDG PET/CT in Patients with Primary Testicular Diffuse Large B-Cell Lymphoma

Functional Parameters of 18F-FDG PET/CT in Patients with Primary Testicular Diffuse Large B-Cell Lymphoma

Associations between GLUT expression and SUV values derived from FDG-PET in different tumors—A systematic review and meta analysis

Physiologic testicular uptake of 18-F fluorodeoxyglucose in the Indian population

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Functional Parameters of ¹⁸F-FDG PET/CT in Patients with Primary Testicular Diffuse Large B-Cell Lymphoma

Functional Parameters of ¹⁸F-FDG PET/CT in Patients with Primary Testicular Diffuse Large B-Cell Lymphoma