Functional Parameters of ¹⁸F-FDG PET/CT in Patients with Primary Testicular Diffuse Large B-Cell Lymphoma

Abstract

Fluorine-18 fluorodeoxyglucose (18F-FDG) positron-emission tomography/computed tomography (PET/CT), a hybrid imaging technique that simultaneously provides functional and anatomical information, has been reported to be useful in lymphoma. The present study was to evaluate the functional parameters of 18F-FDG PET/CT in patients with testicular diffuse large B-cell lymphoma (DLBCL). We retrospectively reviewed medical records of 5095 patients with lymphoma who treated at West China Hospital between March 2003 and January 2017, and selected patients with 18F-FDG PET/CT findings and subsequently biopsy confirmed the invasion of testis with DLBCL. Maximum standardized uptake values (SUVmax), peak standardized uptake values (SUVpeak), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the patients were measured. We evaluated the characteristics of 18F-FDG PET/CT in this population. Six patients ranged in age from 37 to 73 years (median age, 58 years) were included in the analysis. The mean SUVmax was 11.09 and varied between 7.20 and 19.75; mean SUVpeak was 9.56 and ranged between 6.79 and 14.39. In addition, mean MTV 42% was 18.4 and varied between 1.3 and 61.6; mean MTV 2.5 was 34.7 and varied significantly between 1.6 and 141.9. With regard to TLG, mean TLG 42% was 168.906 and ranged from 7.514 to 687.004, while mean TLG 2.5 was 253.972 and ranged from 8.400 to 1127.802. In conclusion, 18F-FDG PET/CT scan is a useful tool in patients with testicular DLBCL. SUV, MTV, and TLG may vary a lot in different patients. SUVmax of testicular DLBCL lesion is relatively higher than that of normal testis. Also, we provided a set of MTV and TLG data and firstly showed their significant correlation with overall survival, which indicated a potential prognostic value of MTV and TLG. However, studies with larger population are needed to confirm these findings.

Prognostic Values of Baseline 18F-FDG PET/CT in Patients with Peripheral T-Cell Lymphoma

“…However, there are also controversial results. Some studies have suggested that there is no significant correlation between SUV max and prognosis in patients with aggressive NHL [31][32][33]. In our present study, we demonstrated that SUV max was an independent predictor of OS but not PFS.…”

18F‐FDG PET/CT use in functional assessment of the testes: A systematic review

“…who established that testicular metabolism, reflected by FDG uptake and testicular volume, increase sharply with the onset of puberty, reach a plateau between the age of 40 and 60 after which they begin to decline. Despite establishing that glycolytic metabolism in the testis and testicular volume decrease over a male's life, no evidence was obtained to prove whether glycolytic activity is correlated with spermatogenesis, sperm metabolism or hormone production, hypothesised to be the most likely factors 17,31,39 . Nevertheless, Yang et al.…”

“…Despite establishing that glycolytic metabolism in the testis and testicular volume decrease over a male's life, no evidence was obtained to prove whether glycolytic activity is correlated with spermatogenesis, sperm metabolism or hormone production, hypothesised to be the most likely factors. 17,31,39 Nevertheless, Yang et al made an important observation regarding any possible correlation. Their results showed that testicular metabolism declines at a slower pace than testicular volume after 60 years of age.…”

Physiologic testicular uptake of 18-F fluorodeoxyglucose in the Indian population

“…Testicular FDG uptake in various malignant and nonmalignant tumors has been reported in various studies. [ 27 28 29 30 31 32 33 34 ] More studies and clinical trials are required and would help formulate uniform guidelines for the management of various testicular diseases.…”