Differentiation among Glioblastoma Multiforme, Solitary Metastatic Tumor, and Lymphoma Using Whole-Tumor Histogram Analysis of the Normalized Cerebral Blood Volume in Enhancing and Perienhancing Lesions

Abstract

BACKGROUND AND PURPOSE:The histogram method has been shown to demonstrate heterogeneous morphologic features of tumor vascularity. This study aimed to determine whether whole-tumor histogram analysis of the normalized CBV for contrast-enhancing lesions and perienhancing lesions can differentiate among GBMs, SMTs, and lymphomas.

The diagnostic role and dynamic changes in cerebrospinal fluid neopterin during treatment of patients with primary central nervous system lymphoma

“…MRI does not have a high specificity for distinguishing PCNSL from glioma and metastatic brain tumors39, 40 and often results in misdiagnosis 6, 8, 9. In the present study, the sensitivity of MRI for the diagnosis of PCNSL was 52.4% (11/21), whereas the sensitivity of CSF Npt concentration for the diagnosis of PCNSL was 90% (9/10) in the 10 false‐negative PCNSL cases.…”

Differentiation between Brain Glioblastoma Multiforme and Solitary Metastasis: Qualitative and Quantitative Analysis Based on Routine MR Imaging

“…7 With regard to the enhancing part of the tumor, DTI and perfusion metrics showed inconsistent conclusions, with some authors believing there was no difference between the 2 types of tumors, 10,13,16 contrary to the others. 6,8,14,15 As for the peritumoral T2 prolongation, the results were also controversial. Some articles demonstrated that the region was helpful in the differentiation between GBM and MET by DWI, DTI, and PWI metrics, 6,8,10,13,15 which is inconsistent with other papers.…”

“…6,8,14,15 As for the peritumoral T2 prolongation, the results were also controversial. Some articles demonstrated that the region was helpful in the differentiation between GBM and MET by DWI, DTI, and PWI metrics, 6,8,10,13,15 which is inconsistent with other papers. 5,7 In some research, the peritumoral T2 prolonged region was artificially divided into 2 parts: the proximal edema and the distal edema, and the results indicated that the proximal edema was helpful for the differentiation.…”

“…3,5,6,8-10,13, 15 The second mainly deals with 1 location: either the enhancing part of the tumor 14,16,17 or the surrounding hyperintense region on the T2WI. 11,12 The third type is focused on 3 locations: the enhancing part of the tumor, regions with peritumoral T2 prolongation, and the necrotic areas within the tumor.…”

“…2,3 Therefore, it is thought to be very difficult to distinguish between these 2 types of tumors with routine MR imaging alone. [4][5][6] Many studies have focused on other advanced MR imaging modalities, such as DTI, 3,5,7,8 DWI, 9,10 PWI, 6,[11][12][13][14][15][16] and MR spectroscopy, 17 to explore the differentiating characteristics.…”