Differentiating unipolar and bipolar depression by alterations in large‐scale brain networks

Goya-Maldonado, Roberto; Brodmann, Katja; Keil, Maria; Trost, Sarah; Dechent, Peter; Gruber, Oliver

doi:10.1002/hbm.23070

Cited by 115 publications

(55 citation statements)

References 58 publications

(82 reference statements)

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“…Our primary finding of decreased negative functional connectivity between the DMN and salience networks is supported by previous studies in adults with BD (16–20, 57). Our findings are also consistent with studies in PBD that reported increased functional connectivity of the DMN to the insula with higher bipolar index scores (34).…”

Section: Discussionsupporting

confidence: 90%

Abnormal Functional Connectivity Between Default and Salience Networks in Pediatric Bipolar Disorder

Lopez-Larson

Shah

Weeks

et al. 2017

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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Section: Discussionsupporting

confidence: 90%

Abnormal Functional Connectivity Between Default and Salience Networks in Pediatric Bipolar Disorder

Lopez-Larson

Shah

Weeks

et al. 2017

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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“…Studies compatible with the hypothesis generally investigated these areas and related networks, finding changes in BD patients that matched the prediction of the model, i.e ., increased strio-anterior cingulate connectivity [24, 32, 48] or decreased cortical-striatal-control [23] in the manic BD phase and  even in euthymia [25, 29, 53] and in unaffected first-degree relatives [38]. Opposite results were found in depressive phases, with decreased activity in the cingulate [63]. The Yamada model-network was more active in patients with BD compared to those with major depressive disorder [64]; although this is not a strong evidence in favour of the PoM hypothesis, it is indicative.…”

Section: Discussionmentioning

confidence: 99%

Neurobiological Evidence for the Primacy of Mania Hypothesis

Kotzalidis¹,

Rapinesi

Savoja

et al. 2017

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Background: Athanasios Koukopoulos proposed the primacy of mania hypothesis (PoM) in a 2006 book chapter and later, in two peer-reviewed papers with Nassir Ghaemi and other collaborators. This hypothesis supports that in bipolar disorder, mania leads to depression, while depression does not lead to mania.Objective: To identify evidence in literature that supports or falsifies this hypothesis.Method: We searched the medical literature (PubMed, Embase, PsycINFO, and the Cochrane Library) for peer-reviewed papers on the primacy of mania, the default mode function of the brain in normal people and in bipolar disorder patients, and on illusion superiority until 6 June, 2016. Papers resulting from searches were considered for appropriateness to our objective. We adopted the PRISMA method for our review. The search for consistency with PoM was filtered through the neurobiological results of superiority illusion studies.Results: Out of a grand total of 139 records, 59 were included in our analysis. Of these, 36 were of uncertain value as to the primacy of mania hypothesis, 22 favoured it, and 1 was contrary, but the latter pooled patients in their manic and depressive phases, so to invalidate possible conclusions about its consistency with regard to PoM. All considered studies were not focused on PoM or superiority illusion, hence most of their results were, as expected, unrelated to the circuitry involved in superiority illusion. A considerable amount of evidence is consistent with the hypothesis, although indirectly so. Limitations. Only few studies compared manic with depressive phases, with the majority including patients in euthymia.Conclusion: It is possible that humans have a natural tendency for elation/optimism and positive self-consideration, that are more akin to mania; the depressive state could be a consequence of frustrated or unsustainable mania. This would be consistent with PoM.

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“…rumination) in unipolar depression is associated with increased default mode network recruitment and reduced salience network recruitment (30-36). Behavioral, emotional and cognitive dysregulation in bipolar disorder is associated with disrupted salience network recruitment and decreased fronto-parietal executive control network recruitment (37-43). Thus, dysfunction in mood disorders may be associated with inefficient or inflexible switching between processing modes.…”

Section: Introductionmentioning

confidence: 99%

Functional Connectivity Between Anterior Insula and Key Nodes of Frontoparietal Executive Control and Salience Networks Distinguish Bipolar Depression From Unipolar Depression and Healthy Control Subjects

Ellard

Zimmerman

Kaur

et al. 2018

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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Impaired functional connectivity between the anterior insula and the inferior parietal lobule of the ECN distinguishes patients with bipolar depression from those with unipolar depression and healthy control subjects. This finding highlights a pathophysiological mechanism with potential as a therapeutic target and a clinical biomarker for bipolar disorder, exhibiting reasonable sensitivity and specificity.

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Differentiating unipolar and bipolar depression by alterations in large‐scale brain networks

Abstract: Unipolar and bipolar groups displaying similar symptomatology could be clearly distinguished by characteristic changes in large-scale networks, encouraging further investigation of network fingerprints for clinical use. Hum Brain Mapp 37:808-818, 2016. © 2015 Wiley Periodicals, Inc.

Cited by 115 publications

References 58 publications

Abnormal Functional Connectivity Between Default and Salience Networks in Pediatric Bipolar Disorder

Abnormal Functional Connectivity Between Default and Salience Networks in Pediatric Bipolar Disorder

Neurobiological Evidence for the Primacy of Mania Hypothesis

Functional Connectivity Between Anterior Insula and Key Nodes of Frontoparietal Executive Control and Salience Networks Distinguish Bipolar Depression From Unipolar Depression and Healthy Control Subjects

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