Functional Connectivity Between Anterior Insula and Key Nodes of Frontoparietal Executive Control and Salience Networks Distinguish Bipolar Depression From Unipolar Depression and Healthy Control Subjects

Ellard, Kristen K.; Zimmerman, Jared P.; Kaur, Navneet; Dijk, Koene R. A. Van; Roffman, Joshua L.; Nierenberg, Andrew A.; Dougherty, Darin D.; Deckersbach, Thilo; Camprodon, Joan A.

doi:10.1016/j.bpsc.2018.01.013

Cited by 54 publications

(56 citation statements)

References 70 publications

(65 reference statements)

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“…Our finding showed increased FC between right AI and several specific brain regions, including the middle temporal gyrus and angular, which are known as nodes of the default network (DMN). These findings are consistent with previous studies of aberrant FC in BD (33)(34)(35). Ellard et al (33) observed that compared to patients with unipolar depression and HCs, BD patients showed significantly aberrant FC between right AI and the IPL in DMN.…”

Section: Discussionsupporting

confidence: 92%

“…These findings are consistent with previous studies of aberrant FC in BD (33)(34)(35). Ellard et al (33) observed that compared to patients with unipolar depression and HCs, BD patients showed significantly aberrant FC between right AI and the IPL in DMN. The DMN might involve in self-referential mental process and social cognition (29,31,36,37).…”

Section: Discussionsupporting

confidence: 92%

“…The MFG and STG has been identified as key nodes in ECN involvement in goal-directed behavior and cognitive control (26,44,45). Previous studies have found the altered FC between dAI and the IPL in the ECN, which was related to impairments of perceived emotion control (33). Additionally, our study observed that BD patients had hypoconnectivity between dAI and precuneus.…”

Section: Discussionsupporting

confidence: 60%

“…Previous findings showed that BD was associated with abnormal structure and function in specific subdivisions of the insula (30)(31)(32). Neuroimaging studies focusing on the resting-state FC (rsFC) of insular subdivisions revealed the discriminative ability of dysfunctional connectivity patterns of anterior insula for bipolar depression (18,33). Hence, the aberrant profiles of insular subregions may provide a novel insight for the pathophysiology of BD depression.…”

Section: Discussionmentioning

confidence: 99%

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The Insular Subregions Topological Characteristics of Patients With Bipolar Depressive Disorder

et al. 2020

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The insular cortex appears to have a crucial role in emotional processing and cognitive control in bipolar disorder (BD). However, most previous studies focused on the entire insular region of BD, neglecting the topological profile of its subregions. Our study aimed to investigate its subregion topological characteristics using the resting-state functional connectivity (rsFC) in patients with BD on depression episode. The magnetic resonance imaging (MRI) data of 28 depressed BD patients and 28 age-and gender-matched healthy controls (HCs) were acquired. We observed that compared to HCs, depressed patients with BD exhibited significantly decreased rsFC between the right ventral anterior insula (vAI) and the left middle temporal gyrus/the right angular, the right dorsal anterior insula (dAI) and the left precuneus, as well as the right posterior insula and the right lingual gyrus. Furthermore, hyperconnectivity was observed between the left dAI and the left medial frontal gyrus, as well as right dAI and left superior temporal gyrus in BD depression. However, no significant group effect was observed between aberrant FC patterns and clinical variables. These findings revealed the functional connectivity patterns of insular subregions for the depressed BD patients, suggesting the potential neural substrate of insular subregions involved in depressive episode of BD. Hence, these results may provide a neural substrate for the potential treatment target of BD on depression episode.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

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The Insular Subregions Topological Characteristics of Patients With Bipolar Depressive Disorder

et al. 2020

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“…In human imaging studies, the dorsal ACC (dACC) responds to relevant environmental stimuli ( Seeley et al, 2007 ; Uddin, 2015 ). The anterior insula (aINS) co-activates along with the dACC to generate, along with other structures, the so-called salience network of brain regions ( Taylor et al, 2009 ; Cai et al, 2014 ; Uddin, 2015 ; Ellard et al, 2018 ). In the rhesus monkey, the ACC and aINS are connected only by large Von Economo neurons (VENs) found in both dACC and aINS ( Mesulam and Mufson, 1982 ).…”

Section: Discussionmentioning

confidence: 99%

Structural Connectivity of the Anterior Cingulate Cortex, Claustrum, and the Anterior Insula of the Mouse

Qadir

Krimmel

et al. 2018

Front. Neuroanat.

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The claustrum is a narrow subcortical brain structure that resides between the striatum and insular cortex. The function of the claustrum is not fully described, and while our previous work supports a role for the claustrum in top-down cognitive control of action, other evidence suggests the claustrum may be involved in detecting salient changes in the external environment. The anterior cingulate cortex (ACC) and the anterior insular (aINS) are the two major participants in the salience network of human brain regions that activate in response to salient stimuli. While bidirectional connections between the ACC and the claustrum exist from mouse to non-human primate, the aINS connectivity with claustrum remains unclear, particularly in mouse. Here, we explored structural connections of the aINS with the claustrum and ACC through adeno-associated virus neuronal tract tracer injections into the ACC and aINS of the mouse. We detected sparse projections from the claustrum to the aINS and diffuse projections from the aINS to the borders of the claustrum were observed in some cases. In contrast, the insular cortex and endopiriform nucleus surrounding the claustrum had rich interconnectivity with aINS. Additionally, we observed a modest interconnectivity between ACC and the aINS. These data support the idea that claustrum neuron responses to salient stimuli may be driven by the ACC rather than the aINS.

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Therapeutic Neuromodulation for Bipolar Disorder—The Case for Biomarker-Driven Treatment Development

Camprodon

2021

JAMA Netw Open

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Transcranial magnetic stimulation (TMS) is a noninvasive neuromodulation technique with both diagnostic and therapeutic clinical applications. Its capacity to facilitate lasting neuroplastic changes has led to a growing number of treatment indications cleared by the US Food and Drug Administration (FDA), including major depressive disorder (MDD), migraine headaches, obsessive compulsive disorder, and smoking cessation. In 2020, the FDA granted breakthrough device designation to TMS for treating bipolar depression. This is not a formal approval, but it indicates interest, is generally supported by evidence, and provides an expedited path for FDA review.Broadly speaking, TMS is not a therapy but rather a tool. However, when it is applied over a specific brain target using specific parameters that facilitate specific neurophysiological changes, then TMS has the potential to become a treatment. Choosing a different target or changing other

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Functional Connectivity Between Anterior Insula and Key Nodes of Frontoparietal Executive Control and Salience Networks Distinguish Bipolar Depression From Unipolar Depression and Healthy Control Subjects

Cited by 54 publications

References 70 publications

The Insular Subregions Topological Characteristics of Patients With Bipolar Depressive Disorder

The Insular Subregions Topological Characteristics of Patients With Bipolar Depressive Disorder

Structural Connectivity of the Anterior Cingulate Cortex, Claustrum, and the Anterior Insula of the Mouse

Therapeutic Neuromodulation for Bipolar Disorder—The Case for Biomarker-Driven Treatment Development

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