Differentiating secondary from primary dengue using IgG to IgM ratio in early dengue: an observational hospital based clinico-serological study from North India

Changal, Khalid; Raina, Adnan; Raina, Manzoor Ahmad; Bashir, Rehana; Latief, Muzamil; Mir, Tanveer; Changal, Qayum Hamid

doi:10.1186/s12879-016-2053-6

Cited by 84 publications

(64 citation statements)

References 24 publications

(25 reference statements)

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“…The prevalence of secondary dengue infection varied in different studies. Two studies by Sidique O et al 15 and Changal K et al 14 reported the prevalence of secondary dengue infection as 68.4 % and 66.7% respectively, which was higher compared to our study results. However, Kumar et al 16 reported the prevalence of secondary dengue infection as 50%.…”

Section: Discussioncontrasting

confidence: 85%

Clinical Profile and Role of Haematological Parameters in the Prognosis of Dengue Fever Patients Admitted in a Tertiary Hospital

Joena¹,

R²

2019

IJCMR

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Introduction: Even after the discovery of vaccines for dengue fever, it remains a major public health problem in developing tropical and subtropical countries, especially in India. The dengue fever has a varied clinical spectrum ranging from a mild headache to severe organ impairment or bleeding, depending on the virulence and susceptibility of the individual. The current study investigated the clinical profile of laboratoryconfirmed dengue patients. A secondary objective was to find the role of haematological parameters in prognosis. Material and Methods: This was a retrospective study conducted in a tertiary care hospital at Madurai following a dengue fever outbreak between August 2017 to November 2017 among laboratory-confirmed dengue patients older than 16 years. All the relevant clinical and laboratory investigation details of the patients were obtained from the medical records of the hospital. Results: Fever was present in all the cases with an average duration of 4.86 ± 1.59 days followed by myalgia (57.39%), vomiting (46.96%), headache (30.43%) and abdominal pain (20%). Bleeding and hepatic complication was presented by 22.16% and 50.43%. The mean platelet recovery duration was 8.42 ± 1.74 days. A strong positive correlation between day of recovery (increasing trend of platelet) from the onset of fever and WBC recovery (r s value: 0.0.713, P value: <0.001) was observed. Conclusion: Dengue fever patients have varied clinical features varying from fever to severe hepatic complication. For assessing the prognosis of dengue fever, along with the continuous monitoring of clinical profile and platelet count, evaluation of WBC recovery is also recommended.

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Section: Discussioncontrasting

confidence: 85%

Clinical Profile and Role of Haematological Parameters in the Prognosis of Dengue Fever Patients Admitted in a Tertiary Hospital

Joena¹,

R²

2019

IJCMR

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“…Delhi, Pune and Hyderabad ( Damodar et al, 2017 ). Various reports from pan India ( Changal et al, 2016 ; Damodar et al, 2017 ; Islam et al, 2016 ; Khan et al, 2014 ; Mishra et al, 2017 ; Muruganandam et al, 2014 and Neeraja et al, 2014 ) and south Asia ( Alera et al, 2016 ; Hapuarachchi et al, 2016 ; Myat et al, 2016 ; Song et al, 2017 and Suleman et al, 2017 ) shows that the co-infections (Infection with more than one serotype), is frequently reported ( Table 4 ). In Dadra & Nagar Haveli the co-infections (infection with more than one serotype) rate is from 7.3% to 17.2% during study period (2014–2016).…”

Section: Resultsmentioning

confidence: 98%

Circulation of dengue serotypes in the Union Territory of Dadra & Nagar Haveli (India)

Zala¹,

Khan²,

Kakadiya³

et al. 2018

Parasite Epidemiology and Control

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The presence of chronological infection by the multi serotype of dengue virus (DENV) is a major contributing factor for the induction of Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). The results indicate that all serotype of dengue along with concurrent infection were reported from the third smallest Union Territory of India furthermore, rare serotype DENV 4, gradually spreads in new areas of India. Therefore, a need to understand the epidemiology of locally circulating serotype and accordingly the control strategy can be implemented. The study was conducted during 2014–2017 in the Union Territory of Dadra & Nagar Haveli (India).

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“…Similarly, in the study done by Changal et al in 2016, 11.7% patients had secondary dengue infection. 12 But in the study done by Vikram et al, the secondary infection rate was 25.3%. 13 Regarding other serological parameters, only NS1 Ag in 144(40%) cases.…”

Section: Discussionmentioning

confidence: 92%

A study on the outbreak of dengue fever in a tertiary care children’s hospital in southern Tamil Nadu, India

Premkumar

Stephenson

Hepzibah³

et al. 2019

Int J Contemp Pediatr

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Background: Dengue fever is the most rapidly spreading mosquito-borne viral disease in the world.Incidence has increased 230-fold with increasing geographic expansion with potential for further spread. The rapidly expanding global footprint of dengue is a public health challenge with an economic burden. This study’s objective is to assess the outbreak of epidemic of dengue fever in a tertiary care children hospital and to describe their socio-demographic, clinical outcome and serological profile.Methods: It is an observational descriptive study conducted for a period of 1 year in less than 12 years old children in a tertiary care hospital at Southern Tamil Nadu.Results: Among the 360 children admitted with dengue fever, there were 198 boys (55%) and 162 (45%) were girls. Maximum incidence of dengue incidence was seen in infants less than 1 year (25%). The highest number of cases were admitted during September and October. The most common affected age group was less than 3 years with 179 (49%). Among the cases, 297 (82%) were of severe dengue which constitute dengue haemorrhagic fever-183(38%) and Dengue shock syndrome 114 (62%). Serological analysis showed NS1 Ag was positive in 144 children (40%), Dengue IgM was positive in 54 children (15%), both IgM and IgG positive in 126 children (35%) and IgG was positive in 36 children (10%). Out of the total children admitted with dengue fever, the case fatality was 0.5% (2 children).Conclusions: This study highlights the importance of WHO clinical criteria for early diagnosis of severe dengue. Moreover, the early and intensive management reduces the mortality significantly.

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Differentiating secondary from primary dengue using IgG to IgM ratio in early dengue: an observational hospital based clinico-serological study from North India

Cited by 84 publications

References 24 publications

Clinical Profile and Role of Haematological Parameters in the Prognosis of Dengue Fever Patients Admitted in a Tertiary Hospital

Clinical Profile and Role of Haematological Parameters in the Prognosis of Dengue Fever Patients Admitted in a Tertiary Hospital

Circulation of dengue serotypes in the Union Territory of Dadra & Nagar Haveli (India)

A study on the outbreak of dengue fever in a tertiary care children’s hospital in southern Tamil Nadu, India

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