Differentiating distinct and converging neural correlates of types of systemic environmental exposures

Abstract

Systemic environmental disadvantage relates to a host of health and functional outcomes. Specific structural factors have seldom been linked to neural structure, however, clouding understanding of putative mechanisms. Examining relations during childhood/preadolescence, a dynamic period of neurodevelopment, could aid bridge this gap. A total of 10,213 youth were recruited from the Adolescent Brain and Cognitive Development study. Self-report and objective measures (Census and Federal bureau of investigation metrics extracted using geocoding) of environmental exposures were used, including stimulation indexing lack of safety and high attentional demands, discrepancy indexing social exclusion/lack of belonging, and deprivation indexing lack of environmental enrichment. Environmental measures were related to cortical thickness, surface area, and subcortical volume regions, controlling for other environmental exposures and accounting for other brain regions. Self-report (jβj = .04-.09)and objective (jβj = .02-.06) environmental domains related to area/thickness in overlapping (e.g., insula, caudal anterior cingulate), and unique regions (e.g., for discrepancy, rostral anterior and isthmus cingulate, implicated in socioemotional functions; for stimulation, precuneus, critical for cue reactivity and integration of environmental cues; and for deprivation, superior frontal, integral to executive functioning). For stimulation and discrepancy exposures, self-report and objective measures showed similarities in correlate regions, while deprivation exposures evidenced distinct correlates for self-report and objective measures. Results represent a necessary step toward broader work aimed at establishing mechanisms and correlates of structural disadvantage, highlighting the relevance of going beyond aggregate models by considering types of environmental factors, and the need to incorporate both subjective and objective measurements in these efforts.

How does the macroenvironment influence brain and behaviour – a review of current status and future perspectives

“…Several studies have demonstrated the effect of neighbourhood disadvantage on brain structure in youth and adults, such as widespread lower volume of WM and GM (178,179), including hippocampus (168,(179)(180)(181), amygdala (168), dlPFC and dorsomedial PFC, superior frontal gyrus (181), IFG and ACC (182). In addition, smaller surface area and cortical thinning was observed in the frontal, parietal, and temporal lobes, cingulate and insula (183)(184)(185)(186)(187). Finally, neighbourhood disadvantage was linked to atypical neurodevelopmental trajectories during adolescence, indicating delayed brain development (188,189).…”