Differentiating Benign and Malignant Breast Lesions with T2*-Weighted First Pass Perfusion Imaging

Kvistad, Kjell Arne; Lundgren, Steinar; Fjøne, H. E.; Smenes, E.; Smethurst, Hanne B.; Haraldseth, Olav

doi:10.1080/02841859909174402

Cited by 43 publications

(16 citation statements)

References 23 publications

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“…We have confirmed findings in previous reports that indicated T2* effects associated with the first pass of a contrast agent in the breast are detectable when the bolus is administered 10 -15 minutes after the first bolus is administered (15)(16)(17). A decrease in signal intensity was observed approximately 15 seconds after injection.…”

Section: Discussionsupporting

confidence: 92%

“…The net result would be a substantial or complete elimination of the effect of change in R2* (⌬R2*). However, results in several qualitative studies have shown that ⌬R2* effects are observable in the breast (15)(16)(17)(18). The purpose of this study was to quantify microcirculation in breast neoplasms with magnetic susceptibility-based contrast-enhanced MR imaging.…”

mentioning

confidence: 98%

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Breast Cancer: Regional Blood Flow and Blood Volume Measured with Magnetic Susceptibility–based MR Imaging—Initial Results

Delille¹,

Slanetz²,

Yeh³

et al. 2002

Radiology

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The purpose of this study was to quantify microcirculation in breast neoplasms with magnetic susceptibility-based contrast material-enhanced magnetic resonance imaging. With this imaging method for invasive cancers, the mean values of the ratios of tumor to normal blood flow and blood volume were significantly higher (P <.002) than those for benign or normal tissue. The method allows independent measurement of regional blood flow and blood volume in breast cancers.

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 98%

Breast Cancer: Regional Blood Flow and Blood Volume Measured with Magnetic Susceptibility–based MR Imaging—Initial Results

Delille¹,

Slanetz²,

Yeh³

et al. 2002

Radiology

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“…It was observed that dynamic breast MRI should be performed during first half of the menstrual cycle (days [3][4][5][6][7][8][9][10][11][12][13][14] in order to minimize interpretative difficulties related to the uptake of gadoli-nium in normal breast tissue due to hormonal functions during the menstrual cycle. The use of PWI in the characterization of breast lesions have been reported [50,51]. These studies have shown the promise in differentiating benign from malignant lesions.…”

Section: Perfusion-weighted Imaging (Pwi)mentioning

confidence: 96%

“…These studies have shown the promise in differentiating benign from malignant lesions. Kuhl et al [50] and Kvistad et al [51] compared T2* images with T1 imaging of malignant tissues and showed stronger decrease in signal intensity whereas perfusion effects in fibroadenomas were minor. This was explained on the basis of perfusion characteristics alone, despite the significant overlap of T1 enhancement patterns.…”

Section: Perfusion-weighted Imaging (Pwi)mentioning

confidence: 97%

Characterization of Breast Lesions by Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS)

Sharma¹,

Sharma²,

Jagannathan

2006

CMIR

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Breast cancer is a major health problem in women, worldwide. A combination of physical examination, mammography, ultrasound and fine needle aspiration cytology (FNAC) or core biopsy is currently the mainstay for preoperative diagnosis of breast lesions. Magnetic resonance imaging (MRI) has been proposed as a useful complimentary modality to provide additional information. It has shown potential in the detection, diagnosis and management of breast cancer. It can be used to improve preoperative staging, follow response to therapy, and to detect local recurrences. Contrast enhanced MRI (CEMRI) has evolved as an important tool in the evaluation of breast abnormalities with high sensitivity (94-100%), but with poor specificity. Recently, diffusion and perfusion MRI techniques have been applied to breast lesion characterization and show promise but warrant further investigations.Characterization of breast lesions may also be assisted by using information of the cellular chemistry provided by in vivo proton MR spectroscopy (MRS). Recent reports have shown that neoplastic breast tissue contains elevated levels of choline containing compounds, which can be used as a biochemical marker for differentiating benign versus malignant tumor and for monitoring treatment response. Presently, the various MR techniques show promise primarily as adjunct to the existing standard detection techniques, and its acceptability as a primary screening method will increase only if specificity can be increased. This review presents the current status of MRI and MRS in breast imaging.Keywords: Magnetic Resonance Imaging (MRI), contrast enhanced MRI (CEMRI), in vivo 1 H and 31 P magnetic resonance spectroscopy (MRS), in vitro and ex vivo MR, breast cancer.

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“…and Kvistad etal. have qualitatively evaluated the value of DSC-MRI for characterising breast lesions [34, 35]. Both studies showed strong signal intensity decreases in malignant tissues with only minor susceptibility effects in fibroadenomas.…”

Section: Dynamic Susceptibility Contrast Enhanced Mri (Dsc-mri)mentioning

confidence: 99%

Imaging Tumour Angiogenesis

Jeswani

Padhani²

2005

Cancer Imaging

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The development of neovasculature via angiogenesis is a vital component of many normal physiological processes and a number of disease states. Neovascularisation is critical for the growth of malignant tumours and for the development and survival of metastases. Recently, the potential of non-invasive imaging for the functional characterisation of neovasculature has become realised. In this review we describe the process of tumour angiogenesis for radiologists and present a summary of the most available computed tomography/magnetic resonance imaging techniques that can depict the functional vascular status of human tumours.

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Differentiating Benign and Malignant Breast Lesions with T2*-Weighted First Pass Perfusion Imaging

Abstract: Addition of a T2*-weighted first pass perfusion sequence with a high temporal resolution can probably increase the differentiation of fibroadenomas from invasive carcinomas in contrast-enhanced MR imaging of the breast.

Cited by 43 publications

References 23 publications

Breast Cancer: Regional Blood Flow and Blood Volume Measured with Magnetic Susceptibility–based MR Imaging—Initial Results

Breast Cancer: Regional Blood Flow and Blood Volume Measured with Magnetic Susceptibility–based MR Imaging—Initial Results

Characterization of Breast Lesions by Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS)

Imaging Tumour Angiogenesis

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