Breast Cancer: Regional Blood Flow and Blood Volume Measured with Magnetic Susceptibility–based MR Imaging—Initial Results

Delille, Jean-Paul; Slanetz, Priscilla J.; Yeh, Edmund; Kopans, Daniel B.; Garrido, Leoncio

doi:10.1148/radiol.2232010428

Cited by 58 publications

(52 citation statements)

References 29 publications

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“…The "f/b" factor can be ignored with higher b values because f generally consists of only a few percentage points. Microperfusion effect has not been observed at a b value of less than 600 sec/mm 2 in normal fibroglandular breast tissue or in adipose tissue, a finding that is consistent with reports that the mammary gland is not a highly vascular organ (15,16). However, the fact that microperfusion is high in both benign and malignant lesions is common knowledge in the scientific community (17).…”

Section: Adc Valuesupporting

confidence: 86%

Diffusion-weighted Imaging of the Breast: Principles and Clinical Applications

Woodhams¹,

Ramadan²,

Stanwell³

et al. 2011

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Diffusion-weighted imaging provides a novel contrast mechanism in magnetic resonance (MR) imaging and has a high sensitivity in the detection of changes in the local biologic environment. A significant advantage of diffusion-weighted MR imaging over conventional contrast material-enhanced MR imaging is its high sensitivity to change in the microscopic cellular environment without the need for intravenous contrast material injection. Approaches to the assessment of diffusion-weighted breast imaging findings include assessment of these data alone and interpretation of the data in conjunction with T2-weighted imaging findings. In addition, the analysis of apparent diffusion coefficient (ADC) value can be undertaken either in isolation or in combination with diffusion-weighted and T2-weighted imaging. Most previous studies have evaluated ADC value alone; however, overlap in the ADC values of malignant and benign disease has been observed. This overlap may be partly due to selection of b value, which can influence the concomitant effect of perfusion and emphasize the contribution of multicomponent model influences. The simultaneous assessment of diffusion-weighted and T2-weighted imaging data and ADC value has the potential to improve specificity. In addition, the use of diffusion-weighted imaging in a standard breast MR imaging protocol may heighten sensitivity and thereby improve diagnostic accuracy. Standardization of diffusion-weighted imaging parameters is needed to allow comparison of multicenter studies and assessment of the clinical utility of diffusion-weighted imaging and ADC values in breast evaluation.

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Section: Adc Valuesupporting

confidence: 86%

Diffusion-weighted Imaging of the Breast: Principles and Clinical Applications

Woodhams¹,

Ramadan²,

Stanwell³

et al. 2011

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155

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“…Some investigators found mean blood volume in malignant tumors to be higher than that in benign tumors when taken as groups (39,40). Other investigators could not find a significant difference in blood volume estimates as a result of the high standard variations of the mean values (4,9,41).…”

Section: Discussionmentioning

confidence: 98%

Quantification of Breast Tumor Microvascular Permeability with Feruglose-enhanced MR Imaging: Initial Phase II Multicenter Trial

Daldrup-Link¹,

Rydland²,

Helbich³

et al. 2003

Radiology

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“…A more stringent test consists of a comparison with MRI and PET studies using tracerbased methods [26,27,49,50]. These have found breast tissue blood flow to be in the 4-6 mL/100mL/ min range, while one study ( [26]) quotes an oxygen consumption rate of 19.8 µmol O 2 /100mL/ s. Our estimate of blood flow, 2.8 ml/min/100 ml is between 1.3 and 2 times lower than the MR and PET values.…”

Section: Metabolic Parameter Estimationmentioning

confidence: 99%

Dynamic Functional and Mechanical Response of Breast Tissue to Compression

Carp¹,

Selb²,

Fang³

et al. 2008

Biomedical Optics

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Physiological tissue dynamics following breast compression offer new contrast mechanisms for evaluating breast health and disease with near infrared spectroscopy. We monitored the total hemoglobin concentration and hemoglobin oxygen saturation in 28 healthy female volunteers subject to repeated fractional mammographic compression. The compression induces a reduction in blood flow, in turn causing a reduction in hemoglobin oxygen saturation. At the same time, a two phase tissue viscoelastic relaxation results in a reduction and redistribution of pressure within the tissue and correspondingly modulates the tissue total hemoglobin concentration and oxygen saturation. We observed a strong correlation between the relaxing pressure and changes in the total hemoglobin concentration bearing evidence of the involvement of different vascular compartments. Consequently, we have developed a model that enables us to disentangle these effects and obtain robust estimates of the tissue oxygen consumption and blood flow. We obtain estimates of 1.9±1.3 µmol/100mL/min for OC and 2.8±1.7 mL/100mL/min for blood flow, consistent with other published values.

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Breast Cancer: Regional Blood Flow and Blood Volume Measured with Magnetic Susceptibility–based MR Imaging—Initial Results

Cited by 58 publications

References 29 publications

Diffusion-weighted Imaging of the Breast: Principles and Clinical Applications

Diffusion-weighted Imaging of the Breast: Principles and Clinical Applications

Quantification of Breast Tumor Microvascular Permeability with Feruglose-enhanced MR Imaging: Initial Phase II Multicenter Trial

Dynamic Functional and Mechanical Response of Breast Tissue to Compression

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