Differentiated thyroid carcinoma: a 5-years survival study at a referral hospital in Brazil

Abstract

BACKGROUND: Although the prognosis of differentiated thyroid carcinoma (DTC) therapy is considered excellent over time, some cases have a poorer prognosis and evolve into death. OBJECTIVE: This study aimed to estimate the 5-year specific survival and to identify prognosis factors in a cohort of DTC adult subjects. METHODS: Survival probability was estimated by Kaplan-Meier’s method in a retrospective hospital-based cohort study. Comparisons were made by log-rank test. Prognosis factors were identified using Cox risk modeling and crude and adjusted Hazard Ratio measures were obtained. Two models were estimated, considering age grouping of the 7th and 8th editions of TNM. RESULTS: Specific 5-year survival in the cohort was 98.5% (95%CI: 94.2 – 97.5). Considering TNM 7th edition, the risk estimates were 9.88 (95%CI: 1.67 – 58.33) for age group ≥ 55 years, 18.87 (95%CI: 7.38 – 48.29) for individuals with distant metastasis, 6.36 (95%CI: 2.26 – 17.91) for patients who underwent lymphadenectomy and 0.16 (95%CI: 0.06 – 0.43) for those who received radioiodine therapy. For TNM 8th edition, the risk estimates were 10.12 (95%CI: 2.05 – 50.09) for age group ≥ 55 years, 12.43 (95%CI: 4.58 – 33.77) for individuals with distant metastasis, 5.06 (95%CI: 1.82 – 14.05) for patients who underwent lymphadenectomy and 0.19 (95%CI: 0.07 – 0.51) for those who received radioiodine therapy. CONCLUSIONS: This cohort had a very high survival over a 5-year period. The prognosis was negatively influenced by age, distant metastasis and lymphadenectomy, whereas radioiodine therapy was found to be protective.

Comparison of safety and efficacy between total endoscopic resection and conventional open surgery for malignant thyroid tumors: a meta-analysis

“…In addition, we compared the total incidences of postoperative complications such as hemorrhage and incisional hematoma, recurrence rate of malignant thyroid gland, and found no significant difference in the four indexes between the two surgical options. The results are consistent with previous studies ( 26 - 28 ). Furthermore, observation on the follow-up evaluation of aesthetic effect in two of the 11 studies indicated that patients would be more satisfied with the results from private scars of ET.…”

“…Thyroid diseases often occur in women, and incidence of thyroid neoplasm tends to increase annually and affect younger population ( 24 ). Most patients with thyroid tumors have better long-term survival after operation ( 25 , 26 ), yet the visible scars from thyroidectomy at the neck become the concerns of patients with their beauty, even certain mental burden, potentially messing the quality of life. Therefore, ET with both treatment and cosmetic outcomes has been introduced and rapidly developed, widely accepted by patients.…”

Is there a relationship between preoperative cytological diagnosis and evolution in patients with differentiated thyroid carcinoma? A retrospective study

“…In this study, comparing the DF and NDF groups, other interesting results were observed regarding age, first STg, RIT, distant metastasis and disease-free time. The NDF group was younger at the time of TT, which was unexpected as older ages have been associated with a worse prognosis (31,32). Perhaps the reason for this difference between the results is due to the strict criteria used in the present study, in which only cases with excellent responses in the last assessment were classified as DF (5).The NDF group also had higher percentages of cases with detectable first STg.…”

Transcriptome Analysis Identified 2 New lncRNAs Associated with the Metastasis of Papillary Thyroid Carcinoma

“…Thyroid carcinoma is the most common malignancy among various cancers in the endocrine system and accounts for approximately 1% of new cancer patients diagnosed each year in the USA [1]. The thyroid malignancy is composed of papillary thyroid carcinoma (PTC) (80%), follicular carcinomas (10%), medullary thyroid carcinomas (5–10%), anaplastic carcinomas (1–2%), primary thyroid lymphomas (rare), and primary thyroid sarcomas (rare) [2, 3]. Papillary thyroid microcarcinoma (PTMC) is a specific subgroup of the PTC with the largest dimension ≤1.0 cm according to the definition by the WHO [4, 5].…”