Differentially expressed plasmatic microRNAs in Brazilian patients with Coronavirus disease 2019 (COVID-19): preliminary results

Nicoletti, Aline de Souza; Visacri, Marília Berlofa; Ronda, Carla da Silva Correa da Regina; Vasconcelos, Pedro; Quintanilha, Júlia Coelho França; Souza, Rafael Nogueira de; Ventura, Deise de Souza; Eguti, Adriana; Silva, Lilian Ferreira de Souza; Perroud, Maurício W.; Catharino, Rodrigo Ramos; Reis, Leonardo Oliveira; Santos, Luiz Augusto Dos; Durán, Nélson; Fávaro, Wagner José; Lancellotti, Marcelo; Costa, José Luiz; Moriel, Patrícia; Pincinato, Eder de Carvalho

doi:10.1007/s11033-022-07338-9

Cited by 18 publications

(14 citation statements)

References 42 publications

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“…65 de Nicoletti et al found several differentially expressed miRNAs between COVID-19 patients and uninfected controls as well as depending on COVID-19 severity (Table 1). 66 Only four patients per group were analyzed and it was not mentioned whether correction for multiple testing was applied.…”

Section: Diagnostic Biomarkersmentioning

confidence: 99%

Host miRNAs as biomarkers of SARS-CoV-2 infection: a critical review

et al. 2023

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Section: Diagnostic Biomarkersmentioning

confidence: 99%

Host miRNAs as biomarkers of SARS-CoV-2 infection: a critical review

et al. 2023

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“…Collected data showed that of these, most of the studies were published during the year 2021 ( n = 16), 53–68 followed by 2022 ( n = 15), 69–83 with the least numbers in the year 2020 ( n = 4) 53,84–87 (Figure 2a). Although the selected studies were published globally, most of them were reported from China ( n = 8), followed by Italy ( n = 7), Spain ( n = 4), and USA ( n = 3).…”

Section: Resultsmentioning

confidence: 99%

Differentially‐regulated miRNAs in COVID‐19: A systematic review

Ahmad

Gull

Baby

et al. 2023

Reviews in Medical Virology

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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for coronavirus disease of 2019 that infected more than 760 million people worldwide with over 6.8 million deaths to date. COVID-19 is one of the most challenging diseases of our times due to the nature of its spread, its effect on multiple organs, and an inability to predict disease prognosis, ranging from being completely asymptomatic to death. Upon infection, SARS-CoV-2 alters the host immune response by changing host-transcriptional machinery. MicroRNAs (miRNAs) are regarded as post-transcriptional regulators of gene expression that can be perturbed by invading viruses. Several in vitro and in vivo studies have reported such dysregulation of host miRNA expression upon SARS-CoV-2 infection. Some of this could occur as an anti-viral response of the host to the viral infection. Viruses themselves can counteract that response by mounting their own pro-viral response that facilitates virus infection, an aspect which may cause pathogenesis. Thus, miRNAs could serve as possible disease biomarkers in infected people. In the current review, we have summarised and analysed the existing data about miRNA dysregulation in patients infected with SARS-CoV-2 to determine their concordance between studies, and identified those that could serve as potential biomarkers during infection, disease progression, and death, even in people with other comorbidities. Having such biomarkers can be vital in not only predicting prognosis, but also the development of novel miRNA-based anti-virals and Abbreviations: 3 0 UTR, 3 0 untranslated regions; 5 0 UTR, 5 0

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“…Since miR-146a and miR-150 surfaced as prominent sepsis-related miRNAs in our review, we specifically searched the literature for their role, if any, in COVID-19 disease. Two reports found circulating miR-150 to be downregulated (as was the case in most sepsis reportssee Table 1) in COVID-19 (Akula et al 2022;Nicoletti et al 2022). Sabattinelli et al looked at miR-146a in the serum of 30 COVID-19 positive patients and 29 healthy controls.…”

Section: Deregulated Mirnas and Their Role In Covid-19 Diseasementioning

confidence: 97%

Role of miRNA dysregulation in sepsis

Formosa

Turgeon

Santos

2022

Mol Med

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Background Sepsis is defined as a state of multisystem organ dysfunction secondary to a dysregulated host response to infection and causes millions of deaths worldwide annually. Novel ways to counteract this disease are needed and such tools may be heralded by a detailed understanding of its molecular pathogenesis. MiRNAs are small RNA molecules that target mRNAs to inhibit or degrade their translation and have important roles in several disease processes including sepsis. Main body The current review adopted a strategic approach to analyzing the widespread literature on the topic of miRNAs and sepsis. A pubmed search of “miRNA or microRNA or small RNA and sepsis not review” up to and including January 2021 led to 1140 manuscripts which were reviewed. Two hundred and thirty-three relevant papers were scrutinized for their content and important themes on the topic were identified and subsequently discussed, including an in-depth look at deregulated miRNAs in sepsis in peripheral blood, myeloid derived suppressor cells and extracellular vesicles. Conclusion Our analysis yielded important observations. Certain miRNAs, namely miR-150 and miR-146a, have consistent directional changes in peripheral blood of septic patients across numerous studies with strong data supporting a role in sepsis pathogenesis. Furthermore, a large body of literature show miRNA signatures of clinical relevance, and lastly, many miRNAs deregulated in sepsis are associated with the process of endothelial dysfunction. This review offers a widespread, up-to-date and detailed discussion of the role of miRNAs in sepsis and is meant to stimulate further work in the field due to the potential of these small miRNAs in prompt diagnostics, prognostication and therapeutic agency.

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Differentially expressed plasmatic microRNAs in Brazilian patients with Coronavirus disease 2019 (COVID-19): preliminary results

Cited by 18 publications

References 42 publications

Host miRNAs as biomarkers of SARS-CoV-2 infection: a critical review

Host miRNAs as biomarkers of SARS-CoV-2 infection: a critical review

Differentially‐regulated miRNAs in COVID‐19: A systematic review

Role of miRNA dysregulation in sepsis

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