Differential temporal and spatial post‐injury alterations in cerebral cell morphology and viability

Amtul, Zareen; Najdat, Abdullah N.; Hill, David J.; Arany, Edith

doi:10.1002/cne.24955

Cited by 3 publications

(1 citation statement)

References 91 publications

(145 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The defective blood-brain barrier (BBB) function (Amtul et al., 2018 ) or vascular phenotype or both leads to dysregulated cerebral blood flow (CBF) (Yang et al., 2014 ) resulting in proteinaceous storage disorders in the brain and cerebral vessels (Amtul et al., 2019 ; 2020 ) of Alzheimer’s patients (Zlokovic, 2008 ). Aggregation of monomeric amyloid β-peptide (Aβ) into Aβ fibrils/oligomeric species of Aβ plaques is a critical step in the pathophysiology of Alzheimer’s disease (AD) (Meinhardt et al., 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Engineering of fluorescent or photoactive Trojan probes for detection and eradication of β-Amyloids

2020

Self Cite

View full text Add to dashboard Cite

Trojan horse technology institutes a potentially promising strategy to bring together a diagnostic or cell-based drug design and a delivery platform. It provides the opportunity to re-engineer a novel multimodal, neurovascular detection probe, or medicine to fuse with blood-brain barrier (BBB) molecular Trojan horse. In Alzheimer’s disease (AD) this could allow the targeted delivery of detection or therapeutic probes across the BBB to the sites of plaques and tangles development to image or decrease amyloid load, enhance perivascular Aβ clearance, and improve cerebral blood flow, owing principally to the significantly improved cerebral permeation. A Trojan horse can also be equipped with photosensitizers, nanoparticles, quantum dots, or fluorescent molecules to function as multiple targeting theranostic compounds that could be activated following changes in disease-specific processes of the diseased tissue such as pH and protease activity, or exogenous stimuli such as, light. This concept review theorizes the use of receptor-mediated transport-based platforms to transform such novel ideas to engineer systemic and smart Trojan detection or therapeutic probes to advance the neurodegenerative field.

show abstract

Section: Introductionmentioning

confidence: 99%

Engineering of fluorescent or photoactive Trojan probes for detection and eradication of β-Amyloids

2020

Self Cite

View full text Add to dashboard Cite

show abstract

Exosomes derived from bone marrow mesenchymal stem cells protect the injured spinal cord by inhibiting pericyte pyroptosis

Zhou

Wen

et al. 2022

Neural Regen Res

View full text Add to dashboard Cite

The effect of NO-generating compounds on the lymphocytes’ ATP content and the relationship with the levels of autoantibodies to glutamate receptors in children who have suffered a traumatic brain injury

Sorokina,

Reutov,

Karaseva

et al. 2024

RPJ

View full text Add to dashboard Cite

Introduction. Inflammation and activation of the immune system are the main cause of secondary injuries in traumatic brain injury (TBI). Given the central role of nitric oxide (NO) in the neuronal Glu cascade with significant changes in the content of ATP in neurons, as well as the presence of GluRc NMDA-type in lymphocytes, it is relevant to determine the effect of NO on the lymphocytes’ adenosine triphosphate (ATP) content. The aim of the work was to determine the effect of different concentrations of NO-generating compounds (NaNO2 and S-nitrosocysteine) on the content of intra- (hcATP) and extracellular ATP (ecATP) in human lymphocytes and to establish links between NO formed during TBI and the initiation of autoimmune processes in children with TBI of varying severity. Materials and methods. Blood samples from 36 TBI children were used for analysis. Lymphocytes were isolated in a ficol gradient according to a standard procedure. The ATP concentration in the tris-acetate buffer (pH 7.76) was determined on a Lucy-1 luminometer using luciferin luciferase (Promega). The ATP concentration was expressed in nmol/mg of protein, which was determined by the Bradford method using Fluka kits. Results. An increase in the level of ATP in lymphocytes immediately after TBI was found to be a positive factor reflecting the activation of lymphocytes. At the same time, a higher level of autontibodies (aAT) to GluRc immediately after severe TBI is a favourable sign for the TBI outcome and coincides with an increase in CGAP in lymphocytes. Prolonged negative trend in ATP content in lymphocytes with similar changes in serum ATP concentrations in severe TBI is an indicator of an unfavourable outcome of severe TBI in children. Conclusion. A moderate increase in NO in the blood immediately after TBI contributes to an increase in CGAP in lymphocytes and aAT to GluRc, which activates the immune response and protects the brain from hypoxic damage.

show abstract

Differential temporal and spatial post‐injury alterations in cerebral cell morphology and viability

Cited by 3 publications

References 91 publications

Engineering of fluorescent or photoactive Trojan probes for detection and eradication of β-Amyloids

Engineering of fluorescent or photoactive Trojan probes for detection and eradication of β-Amyloids

Exosomes derived from bone marrow mesenchymal stem cells protect the injured spinal cord by inhibiting pericyte pyroptosis

The effect of NO-generating compounds on the lymphocytes’ ATP content and the relationship with the levels of autoantibodies to glutamate receptors in children who have suffered a traumatic brain injury

Contact Info

Product

Resources

About