Exosomes derived from bone marrow mesenchymal stem cells protect the injured spinal cord by inhibiting pericyte pyroptosis

Zhou, Yan; Wen, Lulu; Li, Yanfei; Wu, Kaimin; Duan, Ranran; Yao, Yaobing; Jing, Lijun; Gong, Zhe; Teng, Jie; Jia, Yong

doi:10.4103/1673-5374.314323

Cited by 68 publications

(7 citation statements)

References 67 publications

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“…Therefore, the targeting of pyroptosis in other cell types may im- prove histological and functional outcomes after SCI. Zhou et al [115] reported that exosomes derived from bone marrow mesenchymal stem cells effectively reduced pericellular pyroptosis, improved the integrity of the blood-spinal barrier, and promoted functional recovery after SCI. It was also reported that astrocytes play a role in neuroinflammation.…”

Section: Other Cell Typesmentioning

confidence: 99%

Pyroptosis in Spinal Cord Injury: Implications for Pathogenesis and Therapeutic Approaches

Gu,

Yu,

Zou

et al. 2024

Front. Biosci. (Landmark Ed)

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Section: Other Cell Typesmentioning

confidence: 99%

Pyroptosis in Spinal Cord Injury: Implications for Pathogenesis and Therapeutic Approaches

Gu,

Yu,

Zou

et al. 2024

Front. Biosci. (Landmark Ed)

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“…Extracellular vesicles (EVs) are extracellular lipid membrane-bound particles that contain host cell-derived protein or nucleic acid messengers, and have an effect on target cells via paracrine or autocrine regulatory functions [17]. This new type of therapy has the potential to change the microenvironment of healing tissue, reducing the inflammatory process and promoting regeneration, as shown in various studies across different organ systems, such as neural [18], musculoskeletal [19], and cardiac [20] tissues. This systematic review explores whether mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) can facilitate tendon/ligament repair in vivo.…”

Section: Of 30mentioning

confidence: 99%

Mesenchymal Stem Cell-Derived Extracellular Vesicles in Tendon and Ligament Repair—A Systematic Review of In Vivo Studies

Tennyson

Zhang

et al. 2021

Cells

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Tendon and ligament injury poses an increasingly large burden to society. This systematic review explores whether mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) can facilitate tendon/ligament repair in vivo. On 26 May 2021, a systematic search was performed on PubMed, Web of Science, Cochrane Library, Embase, to identify all studies that utilised MSC-EVs for tendon/ligament healing. Studies administering EVs isolated from human or animal-derived MSCs into in vivo models of tendon/ligament injury were included. In vitro, ex vivo, and in silico studies were excluded, and studies without a control group were excluded. Out of 383 studies identified, 11 met the inclusion criteria. Data on isolation, the characterisation of MSCs and EVs, and the in vivo findings in in vivo models were extracted. All included studies reported better tendon/ligament repair following MSC-EV treatment, but not all found improvements in every parameter measured. Biomechanics, an important index for tendon/ligament repair, was reported by only eight studies, from which evidence linking biomechanical alterations to functional improvement was weak. Nevertheless, the studies in this review showcased the safety and efficacy of MSC-EV therapy for tendon/ligament healing, by attenuating the initial inflammatory response and accelerating tendon matrix regeneration, providing a basis for potential clinical use in tendon/ligament repair.

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“…Regarding concomitant injuries there are currently no data, but further reduced cell survival due to compromised local perfusion and dysregulated systemic and local energy metabolism such as hyperglycaemia is very likely. Concerning secrotomic capacity, it has been shown that inflammatory cytokines inhibit the proangiogenic capacity of the soluble component of the MSC secretome [ 280 ], and that the secretomic capacity of BM-MSCs is crucial for the promotion of neuronal survival after TSCI [ 281 ].…”

Section: Tbi Tsci and Mscsmentioning

confidence: 99%

Future Perspectives in Spinal Cord Repair: Brain as Saviour? TSCI with Concurrent TBI: Pathophysiological Interaction and Impact on MSC Treatment

Köhli

Otto

Jahn

et al. 2021

Cells

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Traumatic spinal cord injury (TSCI), commonly caused by high energy trauma in young active patients, is frequently accompanied by traumatic brain injury (TBI). Although combined trauma results in inferior clinical outcomes and a higher mortality rate, the understanding of the pathophysiological interaction of co-occurring TSCI and TBI remains limited. This review provides a detailed overview of the local and systemic alterations due to TSCI and TBI, which severely affect the autonomic and sensory nervous system, immune response, the blood–brain and spinal cord barrier, local perfusion, endocrine homeostasis, posttraumatic metabolism, and circadian rhythm. Because currently developed mesenchymal stem cell (MSC)-based therapeutic strategies for TSCI provide only mild benefit, this review raises awareness of the impact of TSCI–TBI interaction on TSCI pathophysiology and MSC treatment. Therefore, we propose that unravelling the underlying pathophysiology of TSCI with concomitant TBI will reveal promising pharmacological targets and therapeutic strategies for regenerative therapies, further improving MSC therapy.

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Exosomes derived from bone marrow mesenchymal stem cells protect the injured spinal cord by inhibiting pericyte pyroptosis

Cited by 68 publications

References 67 publications

Pyroptosis in Spinal Cord Injury: Implications for Pathogenesis and Therapeutic Approaches

Pyroptosis in Spinal Cord Injury: Implications for Pathogenesis and Therapeutic Approaches

Mesenchymal Stem Cell-Derived Extracellular Vesicles in Tendon and Ligament Repair—A Systematic Review of In Vivo Studies

Future Perspectives in Spinal Cord Repair: Brain as Saviour? TSCI with Concurrent TBI: Pathophysiological Interaction and Impact on MSC Treatment

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