Differential susceptibility to obesity between male, female and ovariectomized female mice

Hong, June Seok; Stubbins, Renee; Smith, Rebekah R; Harvey, Alison E.; Núñez, Nomelí P.

doi:10.1186/1475-2891-8-11

Cited by 251 publications

(220 citation statements)

References 10 publications

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“…21,32 Briefly, the surgical procedure comprised: (1) hair removal over the surgical areas, (2) small incisions (~1.0 cm) were made into the skin halfway between the middle of the back and the base of the tail on both left and right sides, (3) whole ovary removal with a scalpel inserted between the fallopian tubes and the uterine horns, (4) surgical skin closure. 33 Sham operations were also performed in the control group, in which all of the other procedures were exactly the same, except for the removal of the ovaries. Two weeks after OVX, ZOL (Zometa, Novartis, Basel, Switzerland) was injected into the peritoneal cavity (1.6 μg/kg) of the OVX+ZOL group 34 , and continued once a week totally 6 times.…”

Section: Methodsmentioning

confidence: 99%

Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid

Sirisoontorn

Hotokezaka

Hashimoto

et al. 2012

American Journal of Orthodontics and Dentofacial Orthopedics

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Section: Methodsmentioning

confidence: 99%

Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid

Sirisoontorn

Hotokezaka

Hashimoto

et al. 2012

American Journal of Orthodontics and Dentofacial Orthopedics

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“…The research in this area to date shows that male and female mice exhibit profound differences in anatomical adipose tissue distribution and expansion. Studies have shown that even when controlling for diet and other environmental conditions, male mice show significantly greater expansion of total body mass including subcutaneous adipose tissue (SAT), visceral adipose tissue, and liver than their female counterparts (12,14).…”

Section: Sexually Dimorphic Responses In High-fat Dietmentioning

confidence: 99%

Sexually dimorphic myeloid inflammatory and metabolic responses to diet-induced obesity

Griffin

Lanzetta

Eter

et al. 2016

American Journal of Physiology-Regulatory, Integrative and Comp

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Most murine studies are skewed toward the use of male mice to study obesity-induced metabolic dysfunction because of similar protection in female mice. We have investigated dietary obesity in a mouse model and have directly compared inflammatory responses in males and females. In this review we will summarize what is known about sex differences in diet-induced inflammation and will summarize our data on this topic. It is clear that sex differences in high-fat diet-induced inflammatory activation are due to cell intrinsic differences in hematopoietic responses to obesogenic cues, but further research is needed to understand what leads to sexually dimorphic responses. diabetes; high-fat diet; myelopoisis; obesity; sexual dimorphism GLOBAL OBESITY RATES have risen drastically in the past several decades with around one in every three individuals currently categorized as obese (34). The overall incidence of obesityrelated diseases such as diabetes and cardiovascular disease (CVD) also continues to rise as a result (3a). Obesity manifests as the result of an imbalance of caloric intake and energy expenditure. A major contributing factor to the increase in obesity rates is an increase in the consumption of calorie-dense foods rich in saturated fatty acids (4). With increased consumption of high-fat foods, individuals accrue body fat and thus have an elevated risk of developing obesity-related diseases. In this brief review we will emphasize the effects of diet-induced obesity, focusing primarily on sexually dimorphic responses of high-fat diet (HFD) priming of the immune system. An individual's response to HFD is dependent on several factors including sex, age, and ethnicity. What has become increasingly striking is that there is a clear sexual dimorphism in obesity and diabetes rates. While obesity rates are higher in women (34), men have higher rates of cardiovascular disease (CVD) and Type 2 diabetes (30, 36), suggesting that females are protected from the adverse effects of obesity (30). This is of particular importance because when investigating diabetes and CVD, many preclinical studies have been performed in males alone, leaving gaps in our knowledge of sexually dimorphic responses to obesity (45). Therefore, guidelines and therapies are being created based on investigations in males but are being implemented in men and women (13).It is important to investigate males and females to understand the contributing factors to these sex-specific differences. Previous studies have focused on altered hormone environments, anatomical fat distribution (17, 19), and energy expenditure differences. Women have been found to have 10% higher total body fat content compared with males of the same body mass index (BMI) (15). This dimorphism is especially profound in poor socioeconomic conditions, whereas richer environments show a smaller variance in adiposity between the sexes (11). This suggests that estrogen largely influences fat accumulation regardless of socioeconomic status (11). Additionally, when adiposity matched, fema...

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“…Interestingly, the increases of fat mass and body weight were only found in the male rats. It has been reported that male mice are more susceptible to obesity than female mice, and ovarian hormones might provide protection against weight gain [25]. In addition, the ovary is one of the most dynamic endocrine organs in females.…”

Section: Discussionmentioning

confidence: 99%

Wpływ tributylocyny na przyjmowanie pokarmu i ekspresję neuropeptydów w mózgu szczurów

Zhang

Chen

2015

Endokrynologia Polska

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Introduction: Tributyltin (TBT) is a largely diffused environmental pollutant. Several studies have demonstrated that TBT is involved in the development of obesity. However, few studies addressing the effects of TBT on the brain neuropeptides involved in appetite and body weight homeostasis have been published. Material and methods: Experiments were carried out on female and male Sprague-Dawley rats. Animals were exposed to TBT (0.5 μg/kg body weight) for 54 days. The hepatic triglyceride and total cholesterol were determined using commercial enzyme kits. The NPY, AgRP, POMC and CART mRNA expression in brains were quantified by real-time PCR. Results: TBT exposure resulted in significant increases in the hepatic total cholesterol and triglyceride concentration of both male and female rats. Interestingly, increases in body weight and fat mass were only found in the TBT-treated male rats. TBT exposure also led to a significant increase in food intake by the female rats, while no change was observed in the male rats. Moreover, the neuropeptides expression was different between males and females after TBT exposure. TBT induced brain NPY expression in the female rats, and depressed brain POMC, AgRP and CART expression in the males. Conclusions: TBT can increase food intake in female rats, which is associated with the disturbance of NPY in brains. TBT had sex-different effects on brain NPY, AgRP, POMC and CART mRNA expression, which indicates a complex neuroendocrine mechanism of TBT.

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Differential susceptibility to obesity between male, female and ovariectomized female mice

Cited by 251 publications

References 10 publications

Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid

Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid

Sexually dimorphic myeloid inflammatory and metabolic responses to diet-induced obesity

Wpływ tributylocyny na przyjmowanie pokarmu i ekspresję neuropeptydów w mózgu szczurów

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