1995
DOI: 10.1073/pnas.92.10.4377
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Differential subcellular mRNA targeting: deletion of a single nucleotide prevents the transport to axons but not to dendrites of rat hypothalamic magnocellular neurons.

Abstract: It has previously been shown that mRNA encoding the arginine vasopressin (AVP)

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Cited by 50 publications
(35 citation statements)
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“…In conclusion, the discovery of NF-M mRNA within the goldfish M-axon increases the number of known axonally localized mRNAs, including oxytocin mRNA in the rat hypothalamoneurohypophyseal tract [9], caudodorsal cell hormone mRNA in the central nervous system of the mollusc Lymnea stagnalis [5], kinesin mRNA in the squid giant axon [6], and arginine vasopressin precursor mRNA in rat hypothalamo magnocellular neurons [19]. The presence of mRNA in the M-axon is particularly significant given previous reports of tRNA, rRNA, polyribosomes, and protein synthesis in the M-axon [13][14][15].…”
mentioning
confidence: 87%
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“…In conclusion, the discovery of NF-M mRNA within the goldfish M-axon increases the number of known axonally localized mRNAs, including oxytocin mRNA in the rat hypothalamoneurohypophyseal tract [9], caudodorsal cell hormone mRNA in the central nervous system of the mollusc Lymnea stagnalis [5], kinesin mRNA in the squid giant axon [6], and arginine vasopressin precursor mRNA in rat hypothalamo magnocellular neurons [19]. The presence of mRNA in the M-axon is particularly significant given previous reports of tRNA, rRNA, polyribosomes, and protein synthesis in the M-axon [13][14][15].…”
mentioning
confidence: 87%
“…The M-axon is a particularly advantageous preparation because more basic components of the translational machinery (transfer RNA (tRNA), ribosomal RNA (rRNA), and ribosomes) have been identified in the M-axon [13][14][15] compared to any other vertebrate axon. However, no direct evidence has been published for any mRNAs that could function as templates for protein synthesis in M-axoplasm, although mRNAs have been reported in other vertebrate axons [9,19] for which the presence of translational machinery …”
mentioning
confidence: 99%
“…The lack of axonal ribosomes has led to an assumption that translation does not occur in axons, however, some evidence for axonal protein synthesis is beginning to accumulate (reviewed in Van Minnen, 1994). It has also been hypothesized that axonal targeting of mRNA down-regulates protein synthesis by removing these mRNAs from the translating ribosomes (Jirikowski et al, 1990;Mohr et al, 1995). Whether FMRP has any functional significance in the axon still remains to be elucidated; however, it may play a role in the localization or regulation of some axonal mRNAs.…”
Section: Fmrp In Dendritic and Axonal Compartmentsmentioning
confidence: 99%
“…Although axons do not contain ribosomes, they do contain many mRNAs (Perrone-Capano et al, 1987). Some mRNA species have been identified that appear to be specifically targeted to axons, including those for ␤-actin (Olink-Coux and Hollenbeck, 1996), vasopressin (Trembleau et al, 1994;Mohr et al, 1995), oxytocin (Jirikowski et al, 1990), and BC1 (Tiedge et al, 1993). The lack of axonal ribosomes has led to an assumption that translation does not occur in axons, however, some evidence for axonal protein synthesis is beginning to accumulate (reviewed in Van Minnen, 1994).…”
Section: Fmrp In Dendritic and Axonal Compartmentsmentioning
confidence: 99%
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