Differential serotonergic innervation of the suprachiasmatic nucleus and the intergeniculate leaflet and its role in circadian rhythm modulation

Meyer-Bernstein, Elizabeth L.; Morin, L.P.

doi:10.1523/jneurosci.16-06-02097.1996

Cited by 289 publications

(186 citation statements)

References 52 publications

Supporting

Mentioning

167

Contrasting

Unclassified

Order By: Relevance

“…Recent evidence from studies of rodents also highlights the role of serotonin in modulating circadian activity patterns through serotonergic projections to the endogenous circadian pacemaker (Klein et al 1991;Miller et al 1996), the suprachiasmatic nucleus (MeyerBernstein et al 1997;Meyer-Bernstein and Morin 1996). For example, 5-HT is believed to regulate the phasic effects of light on circadian rhythms (Kennaway et al 1996;Meyer-Bernstein and Morin 1996;Prosser et al 1993;Selim et al 1993;Smale et al 1990).…”

Section: Men With Low Cns Serotonin Turnover As Measured By Cerebrosmentioning

confidence: 99%

“…Finally, experimentally induced lesions of the ralphe system lead to nerve terminal decreases in 5-HT and 5-HIAA which are directly proportional to the degree of insomnia produced by the lesions (Jouvet 1974). These findings support the view that increases in CNS serotonin turnover rate promote sleep, in particular NREM sleep, and that deficits in serotonergic transmission are associated with insomnia, high levels of nighttime activity and/or other sleep disturbances (Jouvet 1974;Koella 1985).Recent evidence from studies of rodents also highlights the role of serotonin in modulating circadian activity patterns through serotonergic projections to the endogenous circadian pacemaker (Klein et al 1991;Miller et al 1996), the suprachiasmatic nucleus (MeyerBernstein et al 1997;Meyer-Bernstein and Morin 1996). For example, 5-HT is believed to regulate the phasic effects of light on circadian rhythms (Kennaway et al 1996;Meyer-Bernstein and Morin 1996;Prosser et al 1993;Selim et al 1993;Smale et al 1990).…”

mentioning

confidence: 93%

“…For example, 5-HT is believed to regulate the phasic effects of light on circadian rhythms (Kennaway et al 1996;Meyer-Bernstein and Morin 1996;Prosser et al 1993;Selim et al 1993;Smale et al 1990). Also, fluoxetine-induced increases in serotonergic transmission decrease the duration of circadian periods (Possidente et al 1996), and serotonergic afferents to the suprachiasmatic nucleus are necessary to synchronize nonphotic activity cues into circadian patterns (Edgar et al 1997).…”

mentioning

confidence: 99%

See 2 more Smart Citations

CSF 5-HIAA and Nighttime Activity in Free-Ranging Primates

Mehlman

2000

Neuropsychopharmacology

View full text Add to dashboard Cite

Men with low CNS serotonin turnover, as measured by cerebrospinal fluid 5-hydroxyindoleacetic acid : Sleep, serotonin, impulsivity, primate, aggression Psychiatric research suggests that a reduced turnover rate of serotonin in the central nervous system (CNS), as measured by cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA), is a risk factor for impaired impulse control, violent behavior, and premature mortality from suicide and violence (Faustman et al. 1990;Kruesi et al. 1990;Lidberg et al. 1985;Linnoila et al. Received February 12, 1999; revised June 16, 1999; accepted August 20, 1999. Dr. P.T. Mehlman and Dr. G.C. Westergaard are to be considered as co-first authors whose names are interchangeable. Dr. Mehlman was the Principal Investigator when the study was designed, the data were collected and analyzed, and was the first author when this manuscript was originally submitted. Dr. Westergaard was the Principal Investigator when the manuscript was revised and resubmitted for publication in this journal. Virkkunen et al. 1994). Research using nonhuman primates has replicated and extended many of these findings (Higley et al. 1996a;Higley et al. 1992a;Higley et al. 1996b;Kaplan et al. 1994;Mehlman et al. 1995;Mehlman et al. 1994;Mehlman et al. 1997;Raleigh 1987;Raleigh et al. 1983a;Raleigh et al. 1983b;Raleigh et al. 1980;Raleigh and McGuire 1994). Further, this research has demonstrated that inter-individual differences in CSF 5-HIAA concentrations are stable across time and experimental settings and can be attributed to genetic and early environmental influences that produce lasting modifications in the CNS serotonin response (Higley et al. 1996b;Higley et al. 1994;Higley et al. 1996a).Serotonin-mediated behavioral deficits are thought to result in part from an inability to maintain a homeostatic response in a number of physiological systems (Virkkunen et al. 1989a;Virkkunen and Narvanen 1987;Virkkunen et al. 1994). Various lines of evidence indicate that central serotonin neurotransmission contributes to regulation of sleep-wake cycles and circadian activity patterns. For example, several decades of research has shown that the sleep-wake cycle is partially modulated by serotonin release from projections of the ralphe nuclei (Jacobs 1991;Jouvet 1974;Jouvet 1967;Koella 1985;Koella and Czicman 1966;Maeda et al. 1989;Puizillout et al. 1981). Further, administration of p-chlorophenylalanine (PCPA), which inhibits the synthesis of serotonin, causes a reduction in total sleep in the cat (Jouvet 1974), rat (Torda 1967), and monkey (Weitzman et al. 1968). Finally, experimentally induced lesions of the ralphe system lead to nerve terminal decreases in 5-HT and 5-HIAA which are directly proportional to the degree of insomnia produced by the lesions (Jouvet 1974). These findings support the view that increases in CNS serotonin turnover rate promote sleep, in particular NREM sleep, and that deficits in serotonergic transmission are associated with insomnia, high levels of nighttime activity and/or...

show abstract

Section: Men With Low Cns Serotonin Turnover As Measured By Cerebrosmentioning

confidence: 99%

mentioning

confidence: 93%

mentioning

confidence: 99%

See 1 more Smart Citation

CSF 5-HIAA and Nighttime Activity in Free-Ranging Primates

Mehlman

2000

Neuropsychopharmacology

View full text Add to dashboard Cite

show abstract

“…Two afferent pathways to the SCN that may contribute to phase shifting and entrainment by arousing, nonphotic stimuli include the geniculohypothalamic tract, which is a set of fibers containing NPY, GABA, and possibly other transmitters emanating from the thalamic intergeniculate leaflet (IGL) (Harrington et al, 1985;Morin et al, 1992), and a serotonergic input from the midbrain raphe nuclei (Azmitia and Segal, 1978;Meyer-Bernstein and Morin, 1996). Elimination of NPY input to the SCN by IGL ablation in hamsters and mice is reported to attenuate nonphotic shifting or prevent entrainment in response to running induced by triazolam, novel wheels, or home cage wheels (Johnson et al, 1988;Janik and Mrosovsky, 1994;Wickland and Turek, 1994;Edgar et al, 1997).…”

mentioning

confidence: 99%

Both Neuropeptide Y and Serotonin Are Necessary for Entrainment of Circadian Rhythms in Mice by Daily Treadmill Running Schedules

1997

View full text Add to dashboard Cite

This study investigated the role of the suprachiasmatic nucleus (SCN) circadian pacemaker and its neuropeptide Y (NPY) and serotonin (5-HT) afferents in entrainment (synchronization) of mouse circadian rhythms by treadmill running. Blind C57BL/6j mice were run in treadmills for 3 hr/d for 3-10 weeks after receiving radio-frequency lesions of the SCN or the intergeniculate leaflet (IGL, the source of SCN NPY) or infusions of the 5-HT neurotoxin 5,7-DHT into the SCN area. Of 25 intact mice, 22 entrained and three showed period (, the mean duration of the circadian cycle) modulations to scheduled running. Arrhythmic SCN-ablated mice did not synchronize to scheduled running in a way suggestive of circadian pacemaker mediation. Of 15 mice with IGL lesions, only two with partial lesions entrained. Mice with complete IGL lesions (five), confirmed by immunocytochemistry, showed no entrainment or changes. Of 19 mice with 5-HT lesions, only two with partial lesions entrained. All but two mice with complete (10) or nearly complete (4) 5-HT denervation, confirmed by immunocytochemistry, showed modulations during the treadmill schedule. Failure to entrain was not explained by group differences in before the treadmill schedules. The results indicate that the SCN and both NPY and 5-HT are necessary for entrainment to 24 hr schedules of forced running but that complete loss of 5-HT does not prevent modulations of pacemaker motion by behavioral stimuli. Treadmill entrainment in mice may involve synergistic interactions between 5-HT and NPY afferents at some site within the circadian system.

show abstract

“…3 Effects of Antidepressants 353 Stankov et al 1993), the serotonergic system also plays a critical role in circadian modulation. The SCN receives dense projections from the raphe serotonergic neurons originating in the brainstem (Jacobs and Azmitia 1992;Meyer-Bornstein and Morin 1996;Van De Kar and Lorens 1979). Lesions of the median raphe serotonergic system using the neurotoxic agent 5,7-dihydroxytryptamine (5,7-DHT) produce a severe disruption in rodent circadian locomotor (wheel running) activity, resulting in a decrease in amplitude and a 20% longer activity phase (Morin and Blanchard 1991;Smale et al 1990).…”

mentioning

confidence: 99%

Effects of Antidepressants on 5-HT7 Receptor Regulation in the Rat Hypothalamus

Mullins

Gianutsos

1999

Neuropsychopharmacology

147

101

View full text Add to dashboard Cite

Recent evidence suggests that a novel serotonin receptor 5-HT 7 localized in the hypothalamus downregulates in response to treatment with the antidepressant fluoxetine (Sleight et al. 1995). This receptor has also been implicated in the regulation of circadian rhythms (Lovenberg et al. 1993). Here Depression may involve many possible abnormalities corresponding to multiple biological correlates of dysfunction or dysregulation in either one or several brain neurotransmitter systems (Cooper et al. 1996;Nair and Sharma 1989), a property that may contribute to the apparent disparity in symptomology and response to antidepressant therapy. The strict classical notions of neurotransmitter dysregulation hypotheses that associate depression with a deficiency of a vailable neurotransmitter or subresponsivity of mainly noradrenergic and/ or serotonergic receptor systems are recently being expanded to include disturbances in biological rhythm regulation. Impairment of the efficiency of rhythm maintenance or rhythm desynchronization has been suggested by many to lead to mental fatigue and depression (Goodwin et al. 1982;Hallonquist et al. 1986;Healy 1987;Partonen 1994;Schwartz 1993;Wirz-Justice and Campbell 1982;Wirz-Justice et al. 1995). Clinically, it has been extensively documented that the timing and structure of rhythms in physiological, behavioral, and endocrinological functions seem to be abnormal in depression (Coiro et al. 1993;Duncan 1996;File 1990;Kupfer 1995;Nair and Sharma 1989;Wehr et al. 1979). Furthermore, studies investigating the patterns of circadian rhythms of patients diagnosed with depression have been undertaken with the premise of disturbed rhythmicity as a central theme underlying the etiology of some affective disorders (Duncan 1996;Goodwin et al. 1982;Healy 1987;Siever and Davis, 1985;Souetre et al. 1988).Although melatonin is generally thought to be a primary modulator of circadian function through the suprachiasmatic nucleus (SCN) of the hypothalamus (Armstrong and Redman 1993;Binkley 1993;Cassone et al. 1993;Dubocovich 1991;Ibata et al. 1997;Reiter 1993; From the Bristol-Myers Squibb Company (ULM, ASE), Neuroscience Drug Discovery, Wallingford, Connecticut; and University of Connecticut, Department of Pharmaceutical Sciences (GG), Storrs, Connecticut, USA.Address correspondence to: U. Lena Mullins, Ph.D., BristolMyers Squibb Company, Neuroscience Drug Discovery, Department 408, 5 Research Parkway, Wallingford, Connecticut 06492, USA.Received January 1, 1999; revised March 23, 1999; accepted March 26, 1999. N EUROPSYCHOPHARMACOLOGY 1999 -VOL . 21 , NO . 3 Effects of Antidepressants 353 Stankov et al. 1993), the serotonergic system also plays a critical role in circadian modulation. The SCN receives dense projections from the raphe serotonergic neurons originating in the brainstem (Jacobs and Azmitia 1992;Meyer-Bornstein and Morin 1996;Van De Kar and Lorens 1979). Lesions of the median raphe serotonergic system using the neurotoxic agent 5,7-dihydroxytryptamine (5,7-DHT) produce a sever...

show abstract

Differential serotonergic innervation of the suprachiasmatic nucleus and the intergeniculate leaflet and its role in circadian rhythm modulation

Cited by 289 publications

References 52 publications

CSF 5-HIAA and Nighttime Activity in Free-Ranging Primates

CSF 5-HIAA and Nighttime Activity in Free-Ranging Primates

Both Neuropeptide Y and Serotonin Are Necessary for Entrainment of Circadian Rhythms in Mice by Daily Treadmill Running Schedules

Effects of Antidepressants on 5-HT7 Receptor Regulation in the Rat Hypothalamus

Contact Info

Product

Resources

About