Differential Sensitivity of Cones to Iron-Mediated Oxidative Damage

Rogers, Brian S.; Symons, R.C. Andrew; Komeima, Keiichi; Shen, Jikui; Xiao, Weihong; Swaim, Mara; Gong, Yuanyuan; Kachi, Shu; Campochiaro, Peter A.

doi:10.1167/iovs.06-0528

Cited by 69 publications

(48 citation statements)

References 21 publications

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“…Alternatively, angiotensin II is known to stimulate the local gene expression of proteins related to iron metabolism, 34 which may upregulate ion transporters and facilitate iron uptake. Iron overload leads to oxidative damage, 35 thus the anthocyanin-rich bilberry extract might inhibit this pathway to protect photoreceptor cells from oxidative stress. Therefore, anthocyanin-rich bilberry extract may inhibit multiple pathways in the retina to protect visual function.…”

Section: Vision Preservation By Bilberry Extract S Miyake Et Almentioning

confidence: 99%

Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: cellular and molecular mechanism

Miyake

Takahashi

Sasaki

et al. 2012

Laboratory Investigation

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Anthocyanin-rich bilberry extract, a plant-derived antioxidant, has been utilized as a popular supplement for ocular health worldwide. However, it is unclear whether this extract has any biological effect on visual function, and the mechanism for such an effect is completely unknown. In this study, we generated a mouse model of endotoxin-induced uveitis (EIU) that shows retinal inflammation, as well as uveitis, by injecting lipopolysaccharide. We pretreated the mice with anthocyanin-rich bilberry extract and analyzed the effect on the retina. Anthocyanin-rich bilberry extract prevented the impairment of photoreceptor cell function, as measured by electroretinogram. At the cellular level, we found that the EIU-associated rhodopsin decreased and the shortening of outer segments in photoreceptor cells were suppressed in the bilberry-extract-treated animals. Moreover, the extract prevented both STAT3 activation, which induces inflammation-related rhodopsin decrease, and the increase in interleukin-6 expression, which activates STAT3. In addition to its anti-inflammatory effect, the anthocyanin-rich bilberry extract ameliorated the intracellular elevation of reactive oxygen species and activated NF-kB, a redox-sensitive transcription factor, in the inflamed retina. Our findings indicate that anthocyanin-rich bilberry extract has a protective effect on visual function during retinal inflammation.

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Section: Vision Preservation By Bilberry Extract S Miyake Et Almentioning

confidence: 99%

Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: cellular and molecular mechanism

Miyake

Takahashi

Sasaki

et al. 2012

Laboratory Investigation

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“…Interestingly, studies have revealed that not only can an environmental stress such as exposure to hyperoxia result in structural damage to the retina, but other mechanisms that may involve the generation of reactive oxygen species, such as the reaction of iron with oxygen, can also result in such an effect. For example, intravitreal injection with FeSO 4 has been shown to cause selective thinning of the ONL [25] as well as impaired retinal function. Similarly, intravitreous injection of paraquat (an herbicide known to generate reactive oxygen species) was shown to cause thinning of the ONL and INL along with vacuolization, folds in the ONL and functional impairment [26].…”

Section: Managing Rop: Lessons From Oirmentioning

confidence: 99%

Postnatal hyperoxia and the developing rat retina: beyond the obvious vasculopathy

2009

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Although a great deal of emphasis has been placed on the vasculopathy that is associated with oxygen-induced retinopathy (OIR), our studies also revealed significant and irreversible structural (retinal histology) and functional (scotopic and photopic electroretinograms) impairments that were significantly more severe in pigmented Long-Evans rats compared to the more commonly used albino Sprague Dawley rats. In the following pages, we will highlight what we have learned about the retinal pathophysiological processes of OIR taking place in strains of both rats with the hope that this will trigger investigations into new therapeutic strategies to complement those geared at preventing the vasculopathy.

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“…Rod cells play an essential role in both vision and health of other cells in the retina Bissig et al, 2013;Cingolani et al, 2006;Curcio et al, 1996;Dong et al, 2006;Du et al, 2013;Kassen et al, 2009;Kolesnikov et al, 2010;Komeima et al, 2006;Rogers et al, 2007;Shen et al, 2005;Usui et al, 2009b). Rod cells have two major and highly compartmentalized functions related to vision: light detection in its posterior outer segments and synaptic terminal neurotransmitter release at its anterior pole; the extracellular space surrounding the outer segments [i.e., the subretinal space (SRS)] is also a key compartment for maintaining a healthy dark current and visual cycle (Adijanto et al, 2009;Cao et al, 1996;Li et al, 1994b).…”

Section: Introductionmentioning

confidence: 99%

“…Rod cell-based oxidative stress has been implicated as a common pathogenic event underlying eventual histopathology in DR and RP, among other retinopathies ( Fig. 1) (Cingolani et al, 2006;Dong et al, 2006;Du et al, 2013;Kassen et al, 2009;Komeima et al, 2006;Rogers et al, 2007;Shen et al, 2005;Usui et al, 2009b). A likely source of rod cell oxidative stress is the ellipsoid region of the inner segment which contain~75% of retinal mitochondria (Johnson, Jr. et al, 2007;Medrano and Fox, 1995;Perkins et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

MRI of rod cell compartment-specific function in disease and treatment in vivo

Berkowitz

Bissig

Roberts

2016

Progress in Retinal and Eye Research

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Rod cell oxidative stress is a major pathogenic factor in retinal disease, such as diabetic retinopathy (DR) and retinitis pigmentosa (RP). Personalized, non-destructive, and targeted treatment for these diseases remains elusive since current imaging methods cannot analytically measure treatment efficacy against rod cell compartment-specific oxidative stress in vivo. Over the last decade, novel MRI-based approaches that address this technology gap have been developed. This review summarizes progress in the development of MRI since 2006 that enables earlier evaluation of the impact of disease on rod cell compartment-specific function and the efficacy of anti-oxidant treatment than is currently possible with other methods. Most of the new assays of rod cell compartment-specific function are based on endogenous contrast mechanisms, and this is expected to facilitate their translation into patients with DR and RP, and other oxidative stress-based retinal diseases.

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Differential Sensitivity of Cones to Iron-Mediated Oxidative Damage

Cited by 69 publications

References 21 publications

Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: cellular and molecular mechanism

Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: cellular and molecular mechanism

Postnatal hyperoxia and the developing rat retina: beyond the obvious vasculopathy

MRI of rod cell compartment-specific function in disease and treatment in vivo

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