Differential scanning calorimetry study on drug release from an inulin-based hydrogel and its interaction with a biomembrane model: pH and loading effect

Castelli, Francesco; Sarpietro, Maria Grazia; Micieli, Dorotea; Ottimo, Sara; Pitarresi, Giovanna; Tripodo, Giuseppe; Carlisi, Bianca; Giammona, Gaetano

doi:10.1016/j.ejps.2008.06.005

Cited by 67 publications

(45 citation statements)

References 22 publications

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“…To characterize the hydrogels, the most common techniques used are water uptake [Lohakan et al, 2010;; mechanical properties [Baker et al, 2010;Jiang et al, 2010;Xu et al, 2010]; scanning electron microscopy (SEM) [Moura et al, 2009;Ferrer et al, 2010;Gao et al, 2010;Li et al, 2010;Zhao et al, 2010]; Fourier transform infrared (FTIR) spectroscopy [Kim et al, 2010;; nuclear magnetic resonance (NMR) [Yin et al, 2010]; differential scanning calorimetry (DSC) [Castelli et al, 2008;Rao et al, 2010]; thermogravimetric analysis (TGA) [Rodkate et al, 2010]; structural properties [Panic et al, 2010] through average molar mass between crosslinks (M c ), crosslink density (q), and number of elastically effective chains, completely included in a perfect network, per unit volume (V e ); and controlled release of drugs [Koutroumanis et al, 2010;Liu & Lin, 2010;Sajeesh et al, 2010;Tanigo et al, 2010]; and agrochemicals [Saraydin et al, 2000;Bajpai & Giri, 2003;Bajpai et al, 2006;Wang et al, 2007;Pourjavadi et al, 2009].…”

Section: Characterization Of Hydrogelsmentioning

confidence: 99%

Biodegradable Hydrogel as Delivery Vehicle for the Controlled Release of Pesticide

Aouada¹,

Moura²,

Mattoso³

2011

Pesticides - Formulations, Effects, Fate

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Section: Characterization Of Hydrogelsmentioning

confidence: 99%

Biodegradable Hydrogel as Delivery Vehicle for the Controlled Release of Pesticide

Aouada¹,

Moura²,

Mattoso³

2011

Pesticides - Formulations, Effects, Fate

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“…The significant disappearance and/or reduction in peak intensity was observed in solid dispersion XRPD patterns (Figure 4). This reduction in drug crystallinity was a factor in enhancing drug solubility and dissolution (Hancock & Zografi, 1997;Damian & Blaton et al, 2000;Castelli & Sarpietro et al, 2008).…”

Section: Powder X-ray Diffractionmentioning

confidence: 99%

Effervescent tablet formulation for enhanced patient compliance and the therapeutic effect of risperidone

2014

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1 full factorial design. Trehalose, Inulin, pregelatinized starch, carboxymethylcellulose sodium and Eudragit E100 were used as hydrophilic carriers at different ratios. Rotovap, lyophilization and the kneading-oven were applied as solvent evaporation techniques. Differential scanning calorimetry, X-ray powder diffraction, Fourier transform infrared spectroscopy and scanning electron microscopy showed that the drug was present as amorphous material entrapped within the carrier matrix. Eight tablet blends were prepared using different effervescent mixture ratios with or without binder and lubricant/glidant mixture. All of the blends had acceptable flowability, acceptable effervescence times and immediate drug release that could not be achieved by any of the control formulas. The formula of choice contained 40% effervescent mixture, 5% starch, 1% boric acid, 1% aspartame and sufficient lactose. The relative bioavailability (RB) of risperidone from this formula was 161.41% with a significantly higher extent of absorption compared to the market conventional tablets. This formula may be promising in improving patient compliance and drug efficiency.

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“…Inulin, a β(2-1) linked polysaccharide of D-fructose, is a naturallyoccurring, linear biopolymer found in many plants [1,2]. Inulin is used in various dairy products as a texture improvement agent and is found in a variety of vegetables and fruits such as onion, garlic, banana and chicory [3,4].…”

mentioning

confidence: 99%

“…The inulin-based particles were shown to be non-cytotoxic in fibroblast cell culture, and degradable under acidic and basic conditions. Furthermore, gallic acid and caffeine were used as model drugs for loading and release studies from these particles, illustrating their potential as drug carriers with controlled release.© 2014 Published by Elsevier B.V.Inulin, a β(2-1) linked polysaccharide of D-fructose, is a naturallyoccurring, linear biopolymer found in many plants [1,2]. Inulin is used in various dairy products as a texture improvement agent and is found in a variety of vegetables and fruits such as onion, garlic, banana and chicory [3,4].…”

mentioning

confidence: 99%

“…Inulin is used in various dairy products as a texture improvement agent and is found in a variety of vegetables and fruits such as onion, garlic, banana and chicory [3,4]. Inulin is assumed to be an important food additive due to prebiotic and other protective effects [1][2][3][4]. Therefore, the degradation of inulin as food additive is affected by the food processing temperature and the pH of the medium [5][6][7].…”

mentioning

confidence: 99%

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Synthesis and Properties of Inulin Based Microgels

Şahiner

Sagbas

Yoshida

et al. 2014

Colloids and Interface Science Communications

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Cross-linked inulin (X-inulin) microparticles were synthesized in reverse micelles using water-in-oil microemulsion polymerization. Linear inulin was crosslinked with divinyl sulfone (DVS) in a sodium bis(2-ethylhexyl) sulfosuccinate (AOT) inverse microemulsion under basic conditions. These particles were demonstrated to be excellent scaffolds for the in situ synthesis of CdS quantum dots (Q-dots). The inulin-based particles were shown to be non-cytotoxic in fibroblast cell culture, and degradable under acidic and basic conditions. Furthermore, gallic acid and caffeine were used as model drugs for loading and release studies from these particles, illustrating their potential as drug carriers with controlled release.© 2014 Published by Elsevier B.V.Inulin, a β(2-1) linked polysaccharide of D-fructose, is a naturallyoccurring, linear biopolymer found in many plants [1,2]. Inulin is used in various dairy products as a texture improvement agent and is found in a variety of vegetables and fruits such as onion, garlic, banana and chicory [3,4]. Inulin is assumed to be an important food additive due to prebiotic and other protective effects [1][2][3][4]. Therefore, the degradation of inulin as food additive is affected by the food processing temperature and the pH of the medium [5][6][7]. The advantages of inulin are safety, nontoxicity, ability to form gels, hydrophilicity, biocompatibility, and biodegradability [8][9][10]. Polysaccharides are often used to prepare microparticles because of their excellent properties for nutritional and medicinal applications. Natural biopolymers such as polysaccharides have been widely used as active agent carriers i.e., in drug delivery systems, tissue engineering, pharmaceuticals, and cosmetics [9,[11][12][13][14]. Moreover, hydrogel microparticles with high water absorption capacity can also interact with active agents such as drugs via suitable functional groups for controlled delivery [12].In this study, we describe the preparation and characterization of X-inulin particles and some of their applications. Cross-linked inulin hydrogel particles were synthesized using water-in-oil microemulsion system according to the previously reported method [13] that was the same as preparation of hyaluronic acid, carboxymethyl cellulose and κ-carrageenan particles [14]. Degradation of X-inulin particles was investigated by placing about 20 mg of dried X-inulin particles in a 10 mL buffer solution at pH 2.4 and 10.9 prepared from sodium citrate and hydrochloric acid, and sodium phosphate (Na 2 HPO 4 ) and NaOH, respectively in water bath at 37°C under constant shaking. At certain time intervals, the particles were removed from buffer solutions, centrifuged at 10 000 rpm, and washed with water and after three cycles of centrifugation in acetone, the particles were dried at 50°C until constant weight was attained. Finally, the X-inulin weight losses against incubation time were graphed. To prepare Q-dots within X-inulin particles, 0.2 M 40 mL CdCl 2 solution was prepared, and to this solution, 50...

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Differential scanning calorimetry study on drug release from an inulin-based hydrogel and its interaction with a biomembrane model: pH and loading effect

Cited by 67 publications

References 22 publications

Biodegradable Hydrogel as Delivery Vehicle for the Controlled Release of Pesticide

Biodegradable Hydrogel as Delivery Vehicle for the Controlled Release of Pesticide

Effervescent tablet formulation for enhanced patient compliance and the therapeutic effect of risperidone

Synthesis and Properties of Inulin Based Microgels

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