Differential roles of YTHDF1 and YTHDF3 in embryonic stem cell-derived cardiomyocyte differentiation

Wang, Shen; Zhang, Jun; Xiang, Wu; Lin, Xianrong; Liu, Xiaomin; Zhou, Jun

doi:10.1080/15476286.2020.1850628

Cited by 43 publications

(34 citation statements)

References 30 publications

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“…On the contrary, YTHDF3 knockout accelerates differentiation by promoting the expression of cardiomyocyte specific genes. It is worth noting that YTHDF3 seems to regulate cell differentiation by inhibiting YTHDF1, supporting the opposite role of YTHDF1 and YTHDF3 in cell fate determination (Wang et al, 2020).…”

Section: A Regulation Of Embryonic Developmentmentioning

confidence: 70%

Genetic Regulation of N6-Methyladenosine-RNA in Mammalian Gametogenesis and Embryonic Development

Chang

Man

Wang

et al. 2022

Front. Cell Dev. Biol.

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Emerging evidence shows that m6A is the most abundant modification in eukaryotic RNA molecules. It has only recently been found that this epigenetic modification plays an important role in many physiological and pathological processes, such as cell fate commitment, immune response, obesity, tumorigenesis, and relevant for the present review, gametogenesis. Notably the RNA metabolism process mediated by m6A is controlled and regulated by a series of proteins termed writers, readers and erasers that are highly expressed in germ cells and somatic cells of gonads. Here, we review and discuss the expression and the functional emerging roles of m6A in gametogenesis and early embryogenesis of mammals. Besides updated references about such new topics, readers might find in the present work inspiration and clues to elucidate epigenetic molecular mechanisms of reproductive dysfunction and perspectives for future research.

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Section: A Regulation Of Embryonic Developmentmentioning

confidence: 70%

Genetic Regulation of N6-Methyladenosine-RNA in Mammalian Gametogenesis and Embryonic Development

Chang

Man

Wang

et al. 2022

Front. Cell Dev. Biol.

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“… 81 A study revealed that loss of YTHDF1 triggered significant impairment of cardiomyocyte differentiation. 82 …”

Section: The Roles Of Ythdf1 In Other Nontumor Diseasesmentioning

confidence: 99%

The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases

Chen

Zhong

Xia

et al. 2021

Molecular Therapy - Nucleic Acids

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“…YTHDF1, YTHDF3, YTHDC1 and HNRNPA2/B1 are readers reported to be involved in the regulation of m 6 A in ESCs. Interestingly, YTHDF1 and YTHDF3 not only displayed differential roles in regulating the pluripotency of ESCs, but also showed converse contribution to the cardiac differentiation ( Wang S. et al, 2021 ). Depletion of Ythdf3 in mESCs led to loss of pluripotency with accelerated cardiac differentiation through facilitating the cardiomyocyte-specific genes expression and displayed increased cell proliferation.…”

Section: The Role Of M 6 a In Embryonic Stem Cellsmentioning

confidence: 99%

“…While, Ythdf1 loss resulted in marked impairment of cardiomyocytes differentiation, as well as slightly decreased proliferation. Remarkably, YTHDF3 appears to mediate cellular differentiation partially by suppressing YTHDF1, demonstrating the contrasting but interrelated roles of YTHDF1 and YTHDF3 in determination of cell fate ( Wang S. et al, 2021 ). Additionally, YTHDC1 could recognize the m 6 A-marked LINE1 RNAs in the nucleus and regulate the formation of the LINE1-NCL-KAP1 complex to modulate the RNA scaffold, thus ensuring the appropriate transcriptome and developmental potency of mESCs and early embryos ( Chen C. et al, 2021 ).…”

Section: The Role Of M 6 a In Embryonic Stem Cellsmentioning

confidence: 99%

N6-Methyladenosine RNA Modification: A Potential Regulator of Stem Cell Proliferation and Differentiation

Wei

Zeng

Yang

et al. 2022

Front. Cell Dev. Biol.

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Stem cell transplantation (SCT) holds great promise for overcoming diseases by regenerating damaged cells, tissues and organs. The potential for self-renewal and differentiation is the key to SCT. RNA methylation, a dynamic and reversible epigenetic modification, is able to regulate the ability of stem cells to differentiate and regenerate. N6-methyladenosine (m6A) is the richest form of RNA methylation in eukaryotes and is regulated by three classes of proteins: methyltransferase complexes, demethylase complexes and m6A binding proteins. Through the coordination of these proteins, RNA methylation precisely modulates the expression of important target genes by affecting mRNA stability, translation, selective splicing, processing and microRNA maturation. In this review, we summarize the most recent findings on the regulation of m6A modification in embryonic stem cells, induced pluripotent stem cells and adult stem cells, hoping to provide new insights into improving SCT technology.

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Differential roles of YTHDF1 and YTHDF3 in embryonic stem cell-derived cardiomyocyte differentiation

Cited by 43 publications

References 30 publications

Genetic Regulation of N6-Methyladenosine-RNA in Mammalian Gametogenesis and Embryonic Development

Genetic Regulation of N6-Methyladenosine-RNA in Mammalian Gametogenesis and Embryonic Development

The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases

N6-Methyladenosine RNA Modification: A Potential Regulator of Stem Cell Proliferation and Differentiation

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