Differential Role of Apoptosis and Autophagy Associated with Anticancer Effect of Lupulone (Hop &amp;#946;-Acid) Derivatives on Prostate Cancer Cells

Mouratidis, Petros; Colston, Kay W.; Charolidi, Nicoletta; Pirianov, Grisha

doi:10.2174/1871520614666140623123006

Cited by 12 publications

(12 citation statements)

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“…In this study, it was suggested that higher levels of ATG4B are essential for maximal growth of prostate cancer cells. Another study showed that siRNA-mediated knockdown of ATG4B in prostate cancer cells resulted in increased apoptosis, further supporting the notion that inhibition of ATG4B may be beneficial for reducing prostate cancer growth [95]. This is in contrast to another study that suggested miRNA34A-mediated chemoresistance in prostate cancer cells is-at least in part-mediated by reduced ATG4B expression.…”

Section: Prostate Cancermentioning

confidence: 76%

On ATG4B as Drug Target for Treatment of Solid Tumours—The Knowns and the Unknowns

Agrotis

Ketteler

2019

Cells

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Autophagy is an evolutionary conserved stress survival pathway that has been shown to play an important role in the initiation, progression, and metastasis of multiple cancers; however, little progress has been made to date in translation of basic research to clinical application. This is partially due to an incomplete understanding of the role of autophagy in the different stages of cancer, and also to an incomplete assessment of potential drug targets in the autophagy pathway. While drug discovery efforts are on-going to target enzymes involved in the initiation phase of the autophagosome, e.g., unc51-like autophagy activating kinase (ULK)1/2, vacuolar protein sorting 34 (Vps34), and autophagy-related (ATG)7, we propose that the cysteine protease ATG4B is a bona fide drug target for the development of anti-cancer treatments. In this review, we highlight some of the recent advances in our understanding of the role of ATG4B in autophagy and its relevance to cancer, and perform a critical evaluation of ATG4B as a druggable cancer target.

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Section: Prostate Cancermentioning

confidence: 76%

On ATG4B as Drug Target for Treatment of Solid Tumours—The Knowns and the Unknowns

Agrotis

Ketteler

2019

Cells

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“…Crosstalk between autophagy and other forms of programmed cell death such as apoptosis may occur [21,40,41]. We therefore investigated whether induction of apoptosis might be associated with the response of colon cancer cells to heat.…”

Section: Discussionmentioning

confidence: 99%

A study of thermal dose-induced autophagy, apoptosis and necroptosis in colon cancer cells

Mouratidis

Rivens

Haar

2015

International Journal of Hyperthermia

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“…Humuluslupulus(HOP) extract is rich in phenolic compounds, its components include alpha-acid (humulone), beta-acid (lupulone), xanthoflavonoids, xanthohumunol and isoxanthohumunol [12][13][14][15][16][17][18]. The HOP extract or its components possess antioxidant and anticarcinogenic properties, through the stimulation of apoptosis and inhibition of angiogenesis [13][14][15][16][17][18]. Humulone prevents angiogenesis in embryo chorioallantoic membranes, and inhibits the expression of VEGF in endothelial and tumor cells [13].…”

Section: Issn: 2638-3535mentioning

confidence: 99%

Effects of Humulus lupulus extract or its Components on Viability, Lipid Peroxidation, and expression of Vascular Endothelial Growth Factor in Melanoma Cells and Fibroblasts

Philips¹,

Philips²,

Lozano³

et al. 2017

Madridge J Clin Res

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Cancer and aging are associated with altered cell viability and angiogenesis, which is mediated by vascular endothelial growth factor (VEGF). These alterations have been associated with cellular oxidative stress. Humuluslupulus (HOP) extract, and its components, which include alpha-acid, beta-acid, xanthoflavonoids, xanthohumunol, and isoxanthohumunol, exhibit antioxidant activity. This research examined the effects of HOP extract or its components on direct antioxidant activity, and on cell viability, lipid peroxidation, and expression of VEGF in melanoma cells, and dermal fibroblasts. The HOP extract, and its components exhibited direct antioxidant activity. In melanoma cells, HOP extract, and its components significantly inhibited cell viability and stimulated extracellular lipid hydroperoxides at all examined concentrations; and with few exceptions did not significantly alter intracellular lipid peroxidation or the expression of VEGF. In dermal fibroblasts, HOP extract and its components significantly inhibited cell viability and intracellular lipid peroxidation, and stimulated the expression at VEGF at the highest examined concentration; and with few exceptions did not significantly alter extracellular lipid peroxidation. It is inferred that HOP extract, and its components differentially and beneficially regulate the cellular biochemistry of melanoma cells, and fibroblasts for the management of cancer, and aging.

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Differential Role of Apoptosis and Autophagy Associated with Anticancer Effect of Lupulone (Hop β-Acid) Derivatives on Prostate Cancer Cells

Cited by 12 publications

References 0 publications

On ATG4B as Drug Target for Treatment of Solid Tumours—The Knowns and the Unknowns

On ATG4B as Drug Target for Treatment of Solid Tumours—The Knowns and the Unknowns

A study of thermal dose-induced autophagy, apoptosis and necroptosis in colon cancer cells

Effects of Humulus lupulus extract or its Components on Viability, Lipid Peroxidation, and expression of Vascular Endothelial Growth Factor in Melanoma Cells and Fibroblasts

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