Differential responses of endothelial integrity upon the intake of microencapsulated garlic, tomato extract or a mixture: a single-intake, randomized, double-blind, placebo-controlled crossover trial

Kim, Yunyoung; Kim, Kyeong Jin; Park, Soo-yeon; Lim, Yeni; Kwon, Oran; Lee, Jin Hee; Kim, Ji Yeon

doi:10.1039/c8fo01431k

Cited by 7 publications

(13 citation statements)

References 43 publications

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“…All the RCTs were in English and were carried out between 1993 and 2018. In total, five studies were performed in Asia (Aslani, Entezari, Askari, Maghsoudi, & Maracy, 2016; Bordia, Verma, & Srivastava, 1998; Zhang et al, 2001; Ziaei, Hantoshzadeh, Rezasoltani, & Lamyian, 2001), four in European countries (Kiesewetter et al, 1993; Kim et al, 2018; Scharbert, Kalb, Duris, Marschalek, & Kozek‐Langenecker, 2007; Szulińska et al, 2018; Zhang et al, 2001), three in the United States (Budoff et al, 2004; Steiner & Li, 2001; Womack, Lawton, Redmond, Todd, & Hargens, 2015), and one in Australia (Morris, Burke, Mori, Vandongen, & Beilin, 1995). The sample size of the included studies varied from 18 to 92.…”

Section: Resultsmentioning

confidence: 99%

“…Studies included participants with coronary artery disease (Bordia et al, 1998; Budoff et al, 2004), cerebrovascular disease (Kiesewetter et al, 1993), moderate hyperlipidemia (Aslani et al, 2016), and high risk of preeclampsia (Ziaei et al, 2001), as well as healthy individuals (Morris et al, 1995; Steiner & Li, 2001; Womack et al, 2015) and trainer male runners (Zhang et al, 2001). One study was conducted only on women (Ziaei et al, 2001), three studies included men (Kim et al, 2018; Womack et al, 2015; Zhang et al, 2001), and eight studies included both genders (Aslani et al, 2016; Bordia et al, 1998; Budoff et al, 2004; Kiesewetter et al, 1993; Morris et al, 1995; Scharbert et al, 2007; Steiner & Li, 2001; Szulińska et al, 2018). The parallel design was used in nine studies, while other studies used the crossover design (Kim et al, 2018; Scharbert et al, 2007; Steiner & Li, 2001).…”

Section: Resultsmentioning

confidence: 99%

“…One study was conducted only on women (Ziaei et al, 2001), three studies included men (Kim et al, 2018; Womack et al, 2015; Zhang et al, 2001), and eight studies included both genders (Aslani et al, 2016; Bordia et al, 1998; Budoff et al, 2004; Kiesewetter et al, 1993; Morris et al, 1995; Scharbert et al, 2007; Steiner & Li, 2001; Szulińska et al, 2018). The parallel design was used in nine studies, while other studies used the crossover design (Kim et al, 2018; Scharbert et al, 2007; Steiner & Li, 2001). The combination effect of garlic with other foods was appraised in two studies.…”

Section: Resultsmentioning

confidence: 99%

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A systematic review of randomized controlled trials related to the effects of garlic supplementation on platelet aggregation

Mollahosseini

Hosseini-Marnani

Panjeshahin

et al. 2022

Phytotherapy Research

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The increment of platelet aggregation factors has been considered a key phenomenon in atherosclerosis. Studies have shown that garlic (Allium sativum) is associated with a reduction in platelet aggregation and thrombosis. Hence, the present systematic review was conducted to evaluate the effect of garlic on platelet aggregation. All randomized controlled trials (RCTs) with keywords related to garlic and platelet aggregation were thoroughly searched in electronic databases including PubMed, Scopus, ISI Web of Science, and Google Scholar up to January 2021. Moreover, the references of all related articles were screened to discover more relevant studies. The quality of each study was reported based on Cochrane Collaboration’s tool. In total, 12 studies met the inclusion criteria from 18,235 identified articles (including 595 participants). Most of the studies assessed platelet aggregation in response to different inducers. Of the 12 clinical trials, six studies depicted the beneficial effect of garlic on reducing platelet aggregation. The summary of the quality assessment indicated that most of the studies had high‐quality scores. Regarding the small number of RCTs and heterogeneity between studies, it is impossible to make a proper conclusion about the impacts of garlic on platelet aggregation. Therefore, further precise trials with a standard design are necessary to validate the anti‐thrombotic effect of garlic.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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A systematic review of randomized controlled trials related to the effects of garlic supplementation on platelet aggregation

Mollahosseini

Hosseini-Marnani

Panjeshahin

et al. 2022

Phytotherapy Research

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“…Based on the hypothesis that LPQ180 has a positive effect on lipid metabolism by improving intestinal microbiota composition and related metabolites, we conducted a double-blind, randomized, controlled trial to determine the effects of LPQ180 consumption postprandial lipid responses after oral lipid tolerance test (OLTT) using TNO fat challenge formula [13] in men and women over 20 years of age with a healthy and slightly higher fasting TG levels (<200 mg/dL). In addition, the effect on fecal environments was evaluated.…”

Section: Introductionmentioning

confidence: 99%

Effects of Lactobacillus plantarum Q180 on Postprandial Lipid Levels and Intestinal Environment: A Double-Blind, Randomized, Placebo-Controlled, Parallel Trial

et al. 2020

Self Cite

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Probiotics can improve the intestinal environment by enhancing beneficial bacteria to potentially regulate lipid levels; however, the underlying mechanisms remain unclear. The aim of this study was to investigate the effect of Lactobacillus plantarum Q180 (LPQ180) on postprandial lipid metabolism and the intestinal microbiome environment from a clinical perspective. A double-blind, randomized, placebo-controlled study was conducted including 70 participants of both sexes, 20 years of age and older, with healthy blood triacylglyceride (TG) levels below 200 mg/dL. Treatment with LPQ180 for 12 weeks significantly decreased LDL-cholesterol (p = 0.042) and apolipoprotein (Apo)B-100 (p = 0.003) levels, and decreased postprandial maximum concentrations (Cmax) and areas under the curve (AUC) of TG, chylomicron TG, ApoB-48, and ApoB-100. LPQ180 treatment significantly decreased total indole and phenol levels (p = 0.019). In addition, there was a negative correlation between baseline microbiota abundance and lipid marker change, which was negatively correlated with metabolites. This study suggests that LPQ180 might be developed as a functional ingredient to help maintain healthy postprandial lipid levels through modulating gut environment.

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“…The effects of lycopene and tomato on lipid metabolism have been shown in previous clinical trials; however, almost all trials used tomato juice or tomato extract as the test food in double-blind, placebo-controlled studies [10,11,12]. This is because it is difficult to produce a placebo for raw tomato and to deliver such food products to subjects.…”

Section: Introductionmentioning

confidence: 99%

Effect of 12-Week Daily Intake of the High-Lycopene Tomato (Solanum Lycopersicum), a Variety Named “PR-7”, on Lipid Metabolism: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study

Nishimura

Tominaga²,

Ishikawa-Takano

et al. 2019

Nutrients

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Tomato (Solanum lycopersicum) is a rich source of lycopene, a carotenoid that confers various positive biological effects such as improved lipid metabolism. Here, we conducted a randomized, double-blind, placebo-controlled, parallel-group comparative study to investigate the effects of regular and continuous intake of a new high-lycopene tomato, a variety named PR-7, for 12 weeks, based on 74 healthy Japanese subjects with low-density lipoprotein cholesterol (LDL-C) levels ≥120 to <160 mg/dL. The subjects were randomly assigned to either the high-lycopene tomato or placebo (lycopene-free tomato) group. Each subject in the high-lycopene group ingested 50 g of semidried PR-7 (lycopene, 22.0–27.8 mg/day) each day for 12 weeks, while subjects in the placebo group ingested placebo semidried tomato. Medical interviews were conducted, vital signs were monitored, body composition was determined, and blood and saliva samples were taken at weeks 0 (baseline), 4, 8, and 12. The primary outcome assessed was LDL-C. The intake of high-lycopene tomato increased lycopene levels in this group compared to levels in the placebo group (p < 0.001). In addition, high-lycopene tomato intake improved LDL-C (p = 0.027). The intake of high-lycopene tomato, PR-7, reduced LDL-C and was confirmed to be safe.

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Differential responses of endothelial integrity upon the intake of microencapsulated garlic, tomato extract or a mixture: a single-intake, randomized, double-blind, placebo-controlled crossover trial

Abstract: This study investigated the effect of microencapsulated garlic and/or tomato on endothelial dysfunction induced by the PhenFlex test (PFT) in healthy male smokers.

Cited by 7 publications

References 43 publications

A systematic review of randomized controlled trials related to the effects of garlic supplementation on platelet aggregation

A systematic review of randomized controlled trials related to the effects of garlic supplementation on platelet aggregation

Effects of Lactobacillus plantarum Q180 on Postprandial Lipid Levels and Intestinal Environment: A Double-Blind, Randomized, Placebo-Controlled, Parallel Trial

Effect of 12-Week Daily Intake of the High-Lycopene Tomato (Solanum Lycopersicum), a Variety Named “PR-7”, on Lipid Metabolism: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study

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