Differential regeneration of myocardial infarction depending on the progression of disease and the composition of biomimetic hydrogel

Yoon, So Jeong; Hong, Soyoung; Yao, Fang; Song, Myeongjin; Son, Kuk Hui; Son, Ho Sung; Kim, Sook Kyoung; Sun, Kyung; Park, Yongdoo

doi:10.1016/j.jbiosc.2014.04.001

Cited by 24 publications

(14 citation statements)

References 41 publications

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“…It is significant that the nanofiber network structure of hydrogels provides a possibility of the combination with nanocomposites (Johnson et al, 2011). At the same time, in addition to the degradability of the injectable hydrogel (Tous et al, 2011), the particle size of the hydrogel (Yoon et al, 2014) is equally important to cardiovascular repair effects so that nanocomposite with hydrogel considered as a carrier plays a great potential role in the field of cardiovascular tissue engineering (Kurdi et al, 2010). We will review the common types of active nanomaterials complexed in injectable hydrogels for tissue repair as followed (Figure 3).…”

Section: Injectable Hydrogel-based Nanocompositesmentioning

confidence: 99%

Injectable Hydrogel-Based Nanocomposites for Cardiovascular Diseases

Liao

Yang

Deng

et al. 2020

Front. Bioeng. Biotechnol.

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Cardiovascular diseases (CVDs), including a series of pathological disorders, severely affect millions of people all over the world. To address this issue, several potential therapies have been developed for treating CVDs, including injectable hydrogels as a minimally invasive method. However, the utilization of injectable hydrogel is a bit restricted recently owing to some limitations, such as transporting the therapeutic agent more accurately to the target site and prolonging their retention locally. This review focuses on the advances in injectable hydrogels for CVD, detailing the types of injectable hydrogels (natural or synthetic), especially that complexed with stem cells, cytokines, nano-chemical particles, exosomes, genetic material including DNA or RNA, etc. Moreover, we summarized the mainly prominent mechanism, based on which injectable hydrogel present excellent treating effect of cardiovascular repair. All in all, it is hopefully that injectable hydrogel-based nanocomposites would be a potential candidate through cardiac repair in CVDs treatment.

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Section: Injectable Hydrogel-based Nanocompositesmentioning

confidence: 99%

Injectable Hydrogel-Based Nanocomposites for Cardiovascular Diseases

Liao

Yang

Deng

et al. 2020

Front. Bioeng. Biotechnol.

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“…The main disadvantage of this polymer refers to their week mechanical properties, but these properties can be improved by modifying the molecular structure and composition with various functionalization [3,7,[35][36][37].…”

Section: Hyaluronic Acid (Ha)mentioning

confidence: 99%

Hydrogels for Cardiac Tissue Repair and Regeneration

Grigore¹

2017

J Cardiovasc Med Cardiol

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The main cause of death in the world continues to be cardiovascular disease, which affects annually over 900,000 people and in the entire word approximately 50% of the people suffering myocardial infarction (MI) die within 5 years. MI causes a number of cardiac pathologies like hypertension, blocked coronary arteries and valvular heart diseases resulting ischemic cardiac injury. In the last years, cardiac tissue engineering has made considerable progress, because this progress have been made towards developing injectable hydrogels for the purpose of cardiac repair and/or regeneration. This study aims to provide an updated survey of the major progress in the fl ied of injectable cardiac tissue engineering, including biomaterials (natural, synthetic or hybrid hydrogels), their advantages or disadvantages and the main seeding cell sources. Also, this review focuses on the progress made in the fi eld of hydrogels for cardiac tissue repair and/or regeneration for MI over the last years.

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“…The molecular weight of the hyaluronic acid construct highly impacts infarcted myocardium recovery and its beneficial effects on cardiac function because the unit size affects mechanical properties, angiogenic processess, and other effects of the biomaterial itself [ 121 , 122 ] (Table 3 ). A comparative study of scaffolds that comprised 50 kDa, 130 kDa, and 170 kDa hyaluronic acid units demonstrated that scaffolds composed of 50 kDa units showed the best effects, reducing apoptosis and infarct size from 29.4 % to 3.72 % and increasing ventricular wall thickness fourfold and heart function (LV end-diastolic pressure and Tau-weiss parameter), as analyzed 28 days after therapy [ 121 ]. These results were consistent with previous studies that described lower apoptotic rates and higher angiogenic activities with scaffolds composed of low molecular weight hyaluronic acid [ 122 , 123 ].…”

Section: Natural Scaffold Materials For Myocardial Regenerationmentioning

confidence: 99%

“…These results were consistent with previous studies that described lower apoptotic rates and higher angiogenic activities with scaffolds composed of low molecular weight hyaluronic acid [ 122 , 123 ]. Additionally, this study also evaluated the effects of the 50 kDa hyaluronic acid scaffold, alone or loaded with VEGF, on cardiac regeneration in both sub-acute and chronic MI animal models [ 121 ]. The effects on myocardial recovery and angiogenesis were similar between groups; therefore, VEGF addition did not act synergistically to achieve a significantly different outcome and hyaluronic acid is responsible for the described cardiac benefits [ 121 ].…”

Section: Natural Scaffold Materials For Myocardial Regenerationmentioning

confidence: 99%

In vivo experience with natural scaffolds for myocardial infarction: the times they are a-changin’

2015

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Treating a myocardial infarction (MI), the most frequent cause of death worldwide, remains one of the most exciting medical challenges in the 21st century. Cardiac tissue engineering, a novel emerging treatment, involves the use of therapeutic cells supported by a scaffold for regenerating the infarcted area. It is essential to select the appropriate scaffold material; the ideal one should provide a suitable cellular microenvironment, mimic the native myocardium, and allow mechanical and electrical coupling with host tissues. Among available scaffold materials, natural scaffolds are preferable for achieving these purposes because they possess myocardial extracellular matrix properties and structures. Here, we review several natural scaffolds for applications in MI management, with a focus on pre-clinical studies and clinical trials performed to date. We also evaluate scaffolds combined with different cell types and proteins for their ability to promote improved heart function, contractility and neovascularization, and attenuate adverse ventricular remodeling. Although further refinement is necessary in the coming years, promising results indicate that natural scaffolds may be a valuable translational therapeutic option with clinical impact in MI repair.

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Differential regeneration of myocardial infarction depending on the progression of disease and the composition of biomimetic hydrogel

Cited by 24 publications

References 41 publications

Injectable Hydrogel-Based Nanocomposites for Cardiovascular Diseases

Injectable Hydrogel-Based Nanocomposites for Cardiovascular Diseases

Hydrogels for Cardiac Tissue Repair and Regeneration

In vivo experience with natural scaffolds for myocardial infarction: the times they are a-changin’

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