Injectable Hydrogel-Based Nanocomposites for Cardiovascular Diseases

Liao, Xiaoshan; Yang, Xushan; Deng, Hong; Hao, Yuting; Mao, Lianzhi; Zhang, Rongjun; Liao, Wenzhen; Yuan, Miaomiao

doi:10.3389/fbioe.2020.00251

Cited by 43 publications

(33 citation statements)

References 191 publications

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“…ECM molecules are isolated and utilized directly as injectable hydrogels by intramyocardial injection or intracoronary perfusions. In these approaches, the injectable materials were supplemented with various materials such as DNA/RNA and cell active factors along with cardiac cells and growth factors as well, as shown in Figure 6, which synergistically helped in the repair of the cardiac tissues [51] .…”

Section: Ecm Hydrogels In Cardiac Tissue Repairmentioning

confidence: 99%

“…Representation of cardiac tissues using hydrogels, cardiac cells and growth factors. Adapted with permission from Liao et al [51] can be utilized to coat it over stents for antifouling properties. ECM-based materials are considered the best tool for cardiac tissue repair; however, their poor mechanical strength limits their use alone for the synthesis of stents for PCI.…”

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

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Nanomaterial-based hydrogels for coronary interventions: a mini review

Saxena¹,

Pandey²

2020

Mini-invasive Surg

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Myocardial infarction (MI) has become a major health concern these days. Elevated levels of cholesterol due to improper diet cause severe damage to human health, resulting in the narrowing of blood vessels leading to MI. Different approaches have been used based on surgical and non-surgical treatments for these blockages to cure MI. In this regard, injectable and non-injectable hydrogel-based percutaneous coronary intervention has shown promising applicability for the treatment of cardiac damage and its repair. In this report, we summarize a few hydrogels based on natural polymers such as chitosan, alginate, polyethylene glycol and extracellular matrices to be used for percutaneous coronary intervention in the treatment of MI. Their structure, biological properties and biocompatibilities are discussed, and their existing challenges are also detailed. In addition, the probable solutions to overcome certain set backs are also highlighted.

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Section: Ecm Hydrogels In Cardiac Tissue Repairmentioning

confidence: 99%

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Nanomaterial-based hydrogels for coronary interventions: a mini review

Saxena¹,

Pandey²

2020

Mini-invasive Surg

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“…Cardiovascular diseases remain the leading cause of death worldwide and include pathological disorders such as acute myocardial infarction (AMI) and heart failure [1]. Current treatment options focus primarily on slowing disease progression and ameliorating symptoms, but therapies that regenerate or reverse myocardial remodeling have yet to be developed and/or implemented in clinical practice [2].…”

Section: Introductionmentioning

confidence: 99%

Injectable Hydrogels for Improving Cardiac Cell Therapy—In Vivo Evidence and Translational Challenges

Hoeeg

Dolatshahi-Pirouz

Follin

2021

Gels

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Cell therapy has the potential to regenerate cardiac tissue and treat a variety of cardiac diseases which are currently without effective treatment. This novel approach to treatment has demonstrated clinical efficiency, despite low retention of the cell products in the heart. It has been shown that improving retention often leads to improved functional outcome. A feasible method of improving cell graft retention is administration of injectable hydrogels. Over the last decade, a variety of injectable hydrogels have been investigated preclinically for their potential to improve the effects of cardiac cell therapy. These hydrogels are created with different polymers, properties, and additional functional motifs and differ in their approaches for encapsulating different cell types. Only one combinational therapy has been tested in a clinical randomized controlled trial. In this review, the latest research on the potential of injectable hydrogels for delivery of cell therapy is discussed, together with potential roadblocks for clinical translation and recommendations for future explorations to facilitate future translation.

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“…In this contest, nanotechnologies could help to reduce the current limitations associated to cell therapies. In particular, one of the most promising approaches is based on the in vitro cells’ loading into 3D-scaffolds, such as hydrogels or patches, to improve their engraftment in the injured site, reducing their clearance rate and increasing their differentiation potential [ 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Cardiac Stem Cell-Loaded Delivery Systems: A New Challenge for Myocardial Tissue Regeneration

Mancuso

Barone

Cristiano

et al. 2020

IJMS

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Cardiovascular disease (CVD) remains the leading cause of death in Western countries. Post-myocardial infarction heart failure can be considered a degenerative disease where myocyte loss outweighs any regenerative potential. In this scenario, regenerative biology and tissue engineering can provide effective solutions to repair the infarcted failing heart. The main strategies involve the use of stem and progenitor cells to regenerate/repair lost and dysfunctional tissue, administrated as a suspension or encapsulated in specific delivery systems. Several studies demonstrated that effectiveness of direct injection of cardiac stem cells (CSCs) is limited in humans by the hostile cardiac microenvironment and poor cell engraftment; therefore, the use of injectable hydrogel or pre-formed patches have been strongly advocated to obtain a better integration between delivered stem cells and host myocardial tissue. Several approaches were used to refine these types of constructs, trying to obtain an optimized functional scaffold. Despite the promising features of these stem cells’ delivery systems, few have reached the clinical practice. In this review, we summarize the advantages, and the novelty but also the current limitations of engineered patches and injectable hydrogels for tissue regenerative purposes, offering a perspective of how we believe tissue engineering should evolve to obtain the optimal delivery system applicable to the everyday clinical scenario.

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Injectable Hydrogel-Based Nanocomposites for Cardiovascular Diseases

Cited by 43 publications

References 191 publications

Nanomaterial-based hydrogels for coronary interventions: a mini review

Nanomaterial-based hydrogels for coronary interventions: a mini review

Injectable Hydrogels for Improving Cardiac Cell Therapy—In Vivo Evidence and Translational Challenges

Cardiac Stem Cell-Loaded Delivery Systems: A New Challenge for Myocardial Tissue Regeneration

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