Differential Patterns of Hypoperfusion in Subtypes of Mild Cognitive Impairment

Caffarra, Paolo; Ghetti, Caterina; Concari, Letizia; Venneri, Annalena

doi:10.2174/1874440000802010020

Cited by 30 publications

(24 citation statements)

References 54 publications

(52 reference statements)

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“…For instance, Caffarra et al (2008) accomplished a follow-up study where asd-MCI, a-md-MCIs, and "dysexecutive MCI" patients underwent SPECT evaluation at baseline. Both amnestic groups showed significant hypoperfusion in the left hippocampus and parahippocampal gyrus, but a-mdMCIs showed an additional hypoperfusion in left posterior cingulated gyrus.…”

Section: Discussionmentioning

confidence: 99%

MEG spectral analysis in subtypes of mild cognitive impairment

López

Cuesta

Garcés

et al. 2014

AGE

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Mild cognitive impairment (MCI) has been described as an intermediate stage between normal aging and dementia. Previous studies characterized the alterations of brain oscillatory activity at this stage, but little is known about the differences between single and multidomain amnestic MCI patients. In order to study the patterns of oscillatory magnetic activity in amnestic MCI subtypes, a total of 105 subjects underwent an eyes-closed resting-state magnetoencephalographic recording: 36 healthy controls, 33 amnestic single domain MCIs (a-sd-MCI), and 36 amnestic multidomain MCIs (a-md-MCI). Relative power values were calculated and AGE (2014) compared among groups. Subsequently, relative power values were correlated with neuropsychological tests scores and hippocampal volumes. Both MCI groups showed an increase in relative power in lower frequency bands (delta and theta frequency ranges) and a decrease in power values in higher frequency bands (alpha and beta frequency ranges), as compared with the control group. More importantly, clear differences emerged from the comparison between the two amnestic MCI subtypes. The a-md-MCI group showed a significant power increase within delta and theta ranges and reduced relative power within alpha and beta ranges. Such pattern correlated with the neuropsychological performance, indicating that the a-md-MCI subtype is associated not only with a "slowing" of the spectrum but also with a poorer cognitive status. These results suggest that a-md-MCI patients are characterized by a brain activity profile that is closer to that observed in Alzheimer disease. Therefore, it might be hypothesized that the likelihood of conversion to dementia would be higher within this subtype.

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Section: Discussionmentioning

confidence: 99%

MEG spectral analysis in subtypes of mild cognitive impairment

López

Cuesta

Garcés

et al. 2014

AGE

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“…Hence, the findings in the current study differ in their locations. However, if CBF studies in early AD are examined in detail, it becomes evident that rCBF changes in many cases have also involved increases and decreases in the frontal lobe cortex [21,24,26,29,[48][49][50]. These areas have been reported as secondary findings and not highlighted as the more expected, concurrent posterior changes.…”

Section: Discussionmentioning

confidence: 99%

“…the superior posterior MFC [21,26,29,49,50]. In one of these studies, Caffarra et al [50] reported that all studied MCI subtypes had decreased rCBF in these regions, including individuals with dysexecutive MCI who also had the highest conversion rate to AD.…”

Section: Discussionmentioning

confidence: 99%

CSF Biomarkers Correlate with Cerebral Blood Flow on SPECT in Healthy Elderly

Stomrud

Forsberg

Hägerström

et al. 2012

Dement Geriatr Cogn Disord

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Background: The preclinical patterns of biological markers for Alzheimer’s disease (AD) in vivo need further exploration. The aim of this study was therefore to investigate CSF biomarkers, regional cerebral blood flow (rCBF) and cognitive performance in cognitively healthy older individuals. Method: Within a 2-week period, 32 cognitively healthy older individuals underwent CSF analysis, rCBF measurement and cognitive testing. The CSF was analysed for β-amyloid_1–42 (Aβ42), total tau protein (T-tau) and hyperphosphorylated tau protein (P-tau). The rCBF results were analysed with statistical parametric mapping to investigate rCBF covariance with the other measurements. Results: High CSF P-tau and T-tau levels correlated with decreased rCBF in the right superior posterior medial frontal lobe whereas high CSF P-tau levels also correlated with increased rCBF in the left fronto-temporal border zone area. No significant covariance was seen between rCBF and CSF Aβ42. Neither CSF P-tau and T-tau levels nor rCBF in the current right frontal and left posterior locations were associated with cognitive performance. Conclusions: Our findings suggest a possible correlation between tau pathology and blood flow abnormalities in individuals without any overt cognitive symptoms. An association with AD development is possible but other explanatory mechanisms cannot be excluded.

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“…This conflicting evidence might be related to the inclusion of samples composed of both single-and multiple domain aMCI patients in the meta-analysis. Recent evidence suggests that multiple domain aMCI patients are further along the path in the Alzheimer's disease process than individuals in the single-domain aMCI state and are characterized by alterations that are not only restricted to the left medial temporal lobe (Brambati et al 2009;Caffarra et al 2008;Seo et al 2007;Whitwell et al 2007). Thus, the restrictive inclusion of subjects with carefully diagnosed single-domain aMCI for the present study might explain the lateralization to the left hemisphere.…”

Section: Group Differences In White Matter Measuresmentioning

confidence: 99%

Impaired and preserved aspects of feedback learning in aMCI: contributions of structural connectivity

et al. 2015

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Distinct lines of research demonstrated that patients with amnestic mild cognitive impairment (aMCI), a potential precursor of Alzheimer disease (AD), are particularly impaired in remembering relations between items and that the use of emotional targets can facilitate memory in patients with AD. We link these findings by examining learning through positive and negative feedback in patients with aMCI, and explore its anatomic underpinnings with diffusion tensor imaging and tractography. Compared to healthy controls, patients with single-domain aMCI were impaired in learning from positive feedback, while learning from negative outcomes was preserved. Among pathways within the brain circuit involved in feedback learning, abnormal white matter microstructure was observed in tracts, which connect left-hemispheric amygdala with hippocampus and entorhinal cortex. In all participants, reduced white matter integrity in this left fiber tract was specifically associated with learning from positive outcomes. Microstructure of right-hemispheric tracts between amygdala and entorhinal cortex was related to learning from negative feedback, and was not compromised in aMCI patients. Our results provide new insight into how anatomical connections might contribute to impaired and preserved aspects of learning behaviors in the early AD process and indicate potential compensatory mechanisms.

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Differential Patterns of Hypoperfusion in Subtypes of Mild Cognitive Impairment

Cited by 30 publications

References 54 publications

MEG spectral analysis in subtypes of mild cognitive impairment

MEG spectral analysis in subtypes of mild cognitive impairment

CSF Biomarkers Correlate with Cerebral Blood Flow on SPECT in Healthy Elderly

Impaired and preserved aspects of feedback learning in aMCI: contributions of structural connectivity

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