DIFFERENTIAL PATTERNS OF CIRCULATING INTERCELLULAR ADHESION MOLECULE-1 (cICAM-1) AND VASCULAR CELL ADHESION MOLECULE-1 (cVCAM-1) DURING LIVER ALLOGRAFT REJECTION1,2

Lang, Thomas; Krams, Sheri M.; Villanueva, Janeth C.; Cox, Kenneth L.; So, Samuel; Martinez, Olivia M.

doi:10.1097/00007890-199502270-00025

Cited by 25 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ninova et al believed serum sICAM-1 detection was beneficial to the AR diagnosis and the estimation of anti-rejection therapy effectiveness [3] . Many scholars considered that the increased serum sICAM-1 could be found in infection, ischemia-reperfusion and rejection, while that in bile was seen in AR only, suggesting the detection of sICAM-1 levels in bile might be a higher specific diagnostic index for AR than in serum [5,6,1,3] . Many scholars considered that the increased serum sICAM-1 could be found in infection, ischemia-reperfusion and rejection, while that in bile was seen in AR only, suggesting the detection of sICAM-1 levels in bile might be a higher specific diagnostic index for AR than in serum [5,6,1,3] .…”

Section: Discussionmentioning

confidence: 99%

The role of sICAM-1 detection in the diagnosis of acute rejection following liver transplantation

Chen

2006

J. Huazhong Univ. Sc. Technol.

View full text Add to dashboard Cite

In order to evaluate the applied value of soluble intracellular adhesion molecule-1 (sICAM-1) in acute rejection (AR) following liver transplantation, the expression of sICAM-1 protein was sequentially detected by using ELISA in serum and bile of 43 patients receiving liver transplantation. In AR group, the expression levels of sICAM-1 protein were increased 3 days before and immediately on the establishment of AR diagnosis, and there was significant difference in the expression of bile between AR group and control group (P<0.01). After reversion of AR with hormone intensive therapy, there was significant difference in the sICAM-1 protein expression of serum and bile between AR group and control group. It was concluded that the sequential detection of sICAM-1 protein level in serum and bile was a reliable and noninvasive method for the early diagnosis of AR after liver transplantation and was valuable to observe the curative effects of anti-AR therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

The role of sICAM-1 detection in the diagnosis of acute rejection following liver transplantation

Chen

2006

J. Huazhong Univ. Sc. Technol.

View full text Add to dashboard Cite

show abstract

“…An increase of intercellular adhesion molecule 1 (ICAM‐1) and E‐selectin in serum was observed in relation to ACR. However, neither E‐selectin nor ICAM‐1 could differentiate ACR from an infectious episode. A differentiation was seen between patients with ACR and CMV infection, where ICAM‐1 levels did not increase .…”

Section: Acute Cellular Rejectionmentioning

confidence: 95%

Biomarkers for the diagnosis of acute cellular rejection in liver transplant recipients: A review

Verhelst

Troisi

Colle

et al. 2012

Hepatology Research

View full text Add to dashboard Cite

The gold standard for the diagnosis of acute cellular rejection (ACR) is a liver biopsy. The quest for an alternative noninvasive biomarkers has been long and is ongoing. However, an efficient and useful biomarker has not been developed yet. In this manuscript, we review all possible candidate biomarkers that have been studied in recent years, starting with cytokines and ending with an overview of different newly discovered "omics". Promising paths are being explored but a valid non-invasive biomarker has not been discovered yet.

show abstract

“…Thus, IHC has been used not only to identify bile duct epithelium in the liver, but also to determine the origin of various cell types of hepatic structures (32 Stamenkovic (89). The ligand VCAM-1 is increased on endothelial cells during liver graft rejection and inflammation (55,71,106) and on bile duct epithelium during primary biliary cirrhosis (106). VLA-4 is expressed on certain activated or mature lymphocytes (73).…”

Section: Unpublished Data)mentioning

confidence: 99%

“…Monocytes use either VLA-4 or CD11/ CD 18 to migrate across human endothelium (65). The ligand ICAM-1 is expressed on endothelium, hepatocytes, and bile duct epithelium with cytokine administration or inflammation (13,55,67,77,106 (25). Expression of the Pi form of glutathione-S-transferase may suggest hepatocyte de-differentiation (1, 57).…”

Section: Unpublished Data)mentioning

confidence: 99%

The Use of Immunohistochemistry for Evaluating the Liver

Hall

Rojko

1996

Toxicol Pathol

View full text Add to dashboard Cite

Immunohistochemistry has been utilized in recent years primarily for diagnosis of infectious diseases of the liver, especially in humans. The utility of immunohistochemistry has extended to experimental and toxicologic pathology in a variety of areas: identification of cell phenotype, cell receptors, cytokine and chemikine production, and functional cell changes such as enzyme induction. In addition, markers for experimental carcinogenesis studies are detectable by immunohistochemical changes as well as novel antigen induction such as placental glutathione-S-transferase, oncofetal proteins, oncogene products, and typing of neoplasms. Immunohistochemistry is also used to detect the origin and function of various cell types in developmental and toxicity studies. Careful use of immunohistochemical procedures in conjunction with routine pathology and molecular techniques enhance the ability of the toxicologic pathologist to diagnose unique conditions and to understand mechanisms of lesion development.

show abstract

DIFFERENTIAL PATTERNS OF CIRCULATING INTERCELLULAR ADHESION MOLECULE-1 (cICAM-1) AND VASCULAR CELL ADHESION MOLECULE-1 (cVCAM-1) DURING LIVER ALLOGRAFT REJECTION1,2

Cited by 25 publications

References 0 publications

The role of sICAM-1 detection in the diagnosis of acute rejection following liver transplantation

The role of sICAM-1 detection in the diagnosis of acute rejection following liver transplantation

Biomarkers for the diagnosis of acute cellular rejection in liver transplant recipients: A review

The Use of Immunohistochemistry for Evaluating the Liver

Contact Info

Product

Resources

About