Differential Microbicidal Effects of Bimetallic Iron–Copper Nanoparticles on <i>Escherichia coli</i> and MS2 Coliphage

Kim, Hyung-Eun; Lee, Hye-Jin; Kim, Min‐Sik; Kim, Tae‐Wan; Lee, Hongshin; Kim, Hak-Hyeon; Cho, Min; Hong, Seok-Won; Lee, Chang Ha

doi:10.1021/acs.est.8b06077

Cited by 32 publications

(15 citation statements)

References 35 publications

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“…Indeed, CuO-impregnated masks have shown remarkable anti-influenza virus (H1N1 and H9N2) activity under simulated breathing conditions, and the activity of these materials toward SARS-CoV-2 should be investigated. The viral disinfectant properties of Ag NPs and CuO NPs is further enhanced when they are combined with Fe as bimetallic particles, due to coupled redox reactions between the two metals …”

Section: Nanotechnology Tools To Inactivate Sars-cov-2 In Different E...mentioning

confidence: 99%

Toward Nanotechnology-Enabled Approaches against the COVID-19 Pandemic

et al. 2020

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The COVID-19 outbreak has fueled a global demand for effective diagnosis and treatment as well as mitigation of the spread of infection, all through large-scale approaches such as specific alternative antiviral methods and classical disinfection protocols. Based on an abundance of engineered materials identifiable by their useful physicochemical properties through versatile chemical functionalization, nanotechnology offers a number of approaches to cope with this emergency. Here, through a multidisciplinary Perspective encompassing diverse fields such as virology, biology, medicine, engineering, chemistry, materials science, and computational science, we outline how nanotechnology-based strategies can support the fight against COVID-19, as well as infectious diseases in general, including future pandemics. Considering what we know so far about the life cycle of the virus, we envision key steps where nanotechnology could counter the disease. First, nanoparticles (NPs) can offer alternative methods to classical disinfection protocols used in healthcare settings, thanks to their intrinsic antipathogenic properties and/or their ability to inactivate viruses, bacteria, fungi, or yeasts either photothermally or via photocatalysis-induced reactive oxygen species (ROS) generation. Nanotechnology tools to inactivate SARS-CoV-2 in patients could also be explored. In this case, nanomaterials could be used to deliver drugs to the pulmonary system to inhibit interaction between angiotensin-converting enzyme 2 (ACE2) receptors and viral S protein. Moreover, the concept of “nanoimmunity by design” can help us to design materials for immune modulation, either stimulating or suppressing the immune response, which would find applications in the context of vaccine development for SARS-CoV-2 or in counteracting the cytokine storm, respectively. In addition to disease prevention and therapeutic potential, nanotechnology has important roles in diagnostics, with potential to support the development of simple, fast, and cost-effective nanotechnology-based assays to monitor the presence of SARS-CoV-2 and related biomarkers. In summary, nanotechnology is critical in counteracting COVID-19 and will be vital when preparing for future pandemics.

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Section: Nanotechnology Tools To Inactivate Sars-cov-2 In Different E...mentioning

confidence: 99%

Toward Nanotechnology-Enabled Approaches against the COVID-19 Pandemic

et al. 2020

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“…Divalent elements are catalysts of Fenton reaction producing reactive oxygen species [73]. Based on the premise that both iron and copper produce ROS, NPs have been loaded and aimed against microbes, viruses and fungi [74,75]. Bacteria internalize the nanoparticle complexes that lead to cellular death.…”

Section: Antimicrobial Treatmentmentioning

confidence: 99%

Iron, Copper, and Zinc Homeostasis: Physiology, Physiopathology, and Nanomediated Applications

2021

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Understanding of how the human organism functions has preoccupied researchers in medicine for a very long time. While most of the mechanisms are well understood and detailed thoroughly, medicine has yet much to discover. Iron (Fe), Copper (Cu), and Zinc (Zn) are elements on which organisms, ranging from simple bacteria all the way to complex ones such as mammals, rely on these divalent ions. Compounded by the continuously evolving biotechnologies, these ions are still relevant today. This review article aims at recapping the mechanisms involved in Fe, Cu, and Zn homeostasis. By applying the knowledge and expanding on future research areas, this article aims to shine new light of existing illness. Thanks to the expanding field of nanotechnology, genetic disorders such as hemochromatosis and thalassemia can be managed today. Nanoparticles (NPs) improve delivery of ions and confer targeting capabilities, with the potential for use in treatment and diagnosis. Iron deficiency, cancer, and sepsis are persisting major issues. While targeted delivery using Fe NPs can be used as food fortifiers, chemotherapeutic agents against cancer cells and microbes have been developed using both Fe and Cu NPs. A fast and accurate means of diagnosis is a major impacting factor on outcome of patients, especially when critically ill. Good quality imaging and bed side diagnostic tools are possible using NPs, which may positively impact outcome.

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“…It was assumed that E. coli is strongly affected by the cytotoxicity of Cu(I), whereas MS2 is inactivated primarily due to the oxidative damages of protein capsid and RNA by Cu(II). [ 390 ]…”

Section: Nanotechnology Potential To Inactivate Viruses Under Differe...mentioning

confidence: 99%

Nanoscience versus Viruses: The SARS‐CoV‐2 Case

Gościańska

Freund

Wuttke

2021

Adv Funct Materials

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The outbreak of the coronavirus (SARS‐CoV‐2) pandemic, its rapid spread, and its fatal consequences clearly showed mankind the overwhelming power of nature, and the importance of interdisciplinary research to counter it. Herein, it will be pointed out what challenges arise in fighting nanosized viruses, which feature an outstanding ability to alter their structure and properties to adapt to infection processes, and why nanoscience is extremely powerful to address them. To learn from the past and to be best prepared for the future, this review highlights how the incredible potential of nanoscience can be tapped by mimicking natures’ viruses for the development of maximally efficient pharmaceuticals, e.g., COVID‐19 vaccines, by designing preventive and protective equipment, e.g., face masks, as well as developing nanosensors for early detection of infections.

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Differential Microbicidal Effects of Bimetallic Iron–Copper Nanoparticles on Escherichia coli and MS2 Coliphage

Cited by 32 publications

References 35 publications

Toward Nanotechnology-Enabled Approaches against the COVID-19 Pandemic

Toward Nanotechnology-Enabled Approaches against the COVID-19 Pandemic

Iron, Copper, and Zinc Homeostasis: Physiology, Physiopathology, and Nanomediated Applications

Nanoscience versus Viruses: The SARS‐CoV‐2 Case

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