Differential Involvement of Left Temporolateral and Temporomesial Structures in Verbal Declarative Learning and Memory: Evidence from Temporal Lobe Epilepsy

Helmstaedter, Christoph; Grunwald, T.; Lehnertz, Klaus; Gleißner, Ulrike; Elger, Christian E.

doi:10.1006/brcg.1997.0930

Cited by 204 publications

(155 citation statements)

References 34 publications

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“…Nevertheless, many other studies claim that SelAH confers lower cognitive morbidity, mostly involving language and verbal memory. In fact, many of these studies agree that ATL is particularly cognitively harmful when performed on the dominant hemisphere 6,7,23,27,28,29 -an observation that was also noted in our series.…”

Section: Discussionsupporting

confidence: 86%

Anterior temporal lobectomy versus selective amygdalohippocampectomy in patients with mesial temporal lobe epilepsy

Nascimento

Gatto

Silvado

et al. 2015

Arq. Neuro-Psiquiatr.

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Objective To contribute our experience with surgical treatment of patients with mesial temporal lobe epilepsy (mTLE) undergoing anterior temporal lobectomy (ATL) or selective amygdalohippocampectomy (SelAH). Method This is a retrospective observational study. The sample included patients with medically refractory mTLE due to unilateral mesial temporal sclerosis who underwent either ATL or SelAH, at Hospital de Clinicas – UFPR, from 2005 to 2012. We report seizure outcomes, using Engel classification, cognitive outcomes, using measurements of verbal and visuospatial memories, as well as operative complications. Result Sixty-seven patients (33 ATL, 34 SelAH) were studied; median follow-up was 64 months. There was no statistically significant difference in seizure or neuropsychological outcomes, although verbal memory was more negatively affected in ATL operations on patients’ dominant hemispheres. Higher number of major complications was observed in the ATL group (p = 0.004). Conclusion Seizure and neuropsychological outcomes did not differ. ATL appeared to be associated with higher risk of complications.

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Section: Discussionsupporting

confidence: 86%

Anterior temporal lobectomy versus selective amygdalohippocampectomy in patients with mesial temporal lobe epilepsy

Nascimento

Gatto

Silvado

et al. 2015

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

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“…This separation of function is also seen in data from intracranial recordings Helmstaedter et al, 1997). Using scalp recordings, Olichney et al (2002b) reported that a group of patients with right temporal lobe epilepsy had normal N400 semantic context effects as well as normal N400 and LPC repetition effects.…”

Section: Page 21mentioning

confidence: 67%

Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400

Duncan

Barry

Connolly

et al. 2009

Clinical Neurophysiology

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845

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“…These include comparisons between congruous and incongruous sentence completions , related and unrelated word pairs (Nobre et al, 1994;Nobre and McCarthy, 1995), high-and lowfrequency words (Fernandez et al, 1998), content and function words , and repeated versus initial presentations of isolated words (Smith et al, 1986;Puce et al, 1991;Halgren et al, 1994a,b;Elger et al, 1997;Helmstaedter et al, 1997;Fernandez et al, 1998;Grunwald et al, 1998). Many of these studies have converged to suggest an N400 generator in the anterior medial temporal lobe (AMTL).…”

Section: Figmentioning

confidence: 99%

N400-like Magnetoencephalography Responses Modulated by Semantic Context, Word Frequency, and Lexical Class in Sentences

et al. 2002

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Words have been found to elicit a negative potential at the scalp peaking at ϳ400 ms that is strongly modulated by semantic context. The current study used whole-head magnetoencephalography (MEG) as male subjects read sentences ending with semantically congruous or incongruous words. Compared with congruous words, sentence-terminal incongruous words consistently evoked a large magnetic field over the left hemisphere, peaking at ϳ450 ms. Source modeling at this latency with conventional equivalent current dipoles (ECDs) placed the N400m generator in or near the left superior temporal sulcus. A distributed solution constrained to the cortical surface suggested a sequence of differential activation, beginning in Wernicke's area at ϳ250 ms, spreading to anterior temporal sites at ϳ270 ms, to Broca's area by ϳ300 ms, to dorsolateral prefrontal cortices by ϳ320 ms, and to anterior orbital and frontopolar cortices by ϳ370 ms. Differential activity was exclusively left-sided until >370 ms, and then involved right anterior temporal and orbital cortices. At the peak of the N400m, activation in the left hemisphere was estimated to be widespread in the anterior temporal, perisylvian, orbital, frontopolar, and dorsolateral prefrontal cortices. In the right hemisphere, the orbital, as well as, weakly, the right anterior temporal cortices were activated. Similar but weaker field patterns were evoked by intermediate words in the sentences, especially to low-frequency words occurring in early sentence positions where there is little preceding context. The locations of the N400m sources identified with the distributed solution correspond well with those previously demonstrated with direct intracranial recordings, and suggested by functional magnetic resonance imaging (fMRI). These results help identify a distributed cortical network that supports online semantic processing. © 2002 Elsevier Science (USA)

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Differential Involvement of Left Temporolateral and Temporomesial Structures in Verbal Declarative Learning and Memory: Evidence from Temporal Lobe Epilepsy

Cited by 204 publications

References 34 publications

Anterior temporal lobectomy versus selective amygdalohippocampectomy in patients with mesial temporal lobe epilepsy

Anterior temporal lobectomy versus selective amygdalohippocampectomy in patients with mesial temporal lobe epilepsy

Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400

N400-like Magnetoencephalography Responses Modulated by Semantic Context, Word Frequency, and Lexical Class in Sentences

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