Differential integrative omic analysis for mechanism insights and biomarker discovery of abnormal Savda syndrome and its unique Munziq prescription

Abstract

Research has shown that many cancers have acommon pathophysiological origin and often present with similar symptoms. In terms of Traditional Uighur Medicine (TUM) Hilit (body fluid) theory, abnormal Savda syndrome (ASS) formed by abnormal Hilit is the common phenotype of complex diseases and in particular tumours. Abnormal Savda Munziq (ASMq), one representative of TUM, has been effective in the treatment of cancer since ancient times. Despite the physiopathology of ASS, the relationship between causative factors and the molecular mechanism of ASMq are not fully understood. The current study expanded upon earlier work by integrating traditional diagnostic approaches with others utilizing systems biology technology for the analysis of proteomic (iTRAQ) and metabolomic (1H-NMR) profiles of Uighur Medicine target organ lesion (liver) tumours. The candidate proteins were analyzed by enrichment analysis of the biological process and biomarker filters. Subsequently, 3Omics web-based tools were used to determine the relationships between proteins and appropriate metabolites. ELISA assay and IHC methods were used to verify the proteomic result; the protein von Willebrand factor (vWF) may be the “therapeutic window” of ASMq and biomarkers of ASS. This study is likely to be of great significance for the standardization and modernization of TUM.

ASMq protects against early burn wound progression in rats by alleviating oxidative stress and secondary mitochondria‑associated apoptosis via the Erk/p90RSK/Bad pathway

“…When the internal environment changes, these four body fluids become AS, which can be harmful to various organs (10). With advancements of science and technology, research into Uyghur traditional medicine has become more in-depth, with significant progress in drug extraction and component analysis (33)(34)(35). ASMq, a natural compound of traditional Uyghur Medicine, has been reported to exhibit anti-inflammatory, antioxidant and anti-apoptotic effects, and decreases oxidative damage by free radicals (10)(11)(12)(13)(14)(15)(16)(17).…”

Multi-omics Data Integration, Interpretation, and Its Application

“…87 Inter-omics analysis and visualization of this platform aided in deriving biomarkers and insights into abnormal Savda syndrome treatment using traditional Uyghur medicines (TUM). 95…”

Research on Establishment of Abnormal Phlegmatic Syndrome with Premature Ovarian Failure Rat Model and Effects of Balgham Munziq Treatment

“…Meanwhile, those four Hilits also maintain the normal physiological status of the body. Nonetheless, once the balance between Hilits is broken, this would cause many different diseases [ 19 , 20 ]. BMq, a traditional Uighur herbal medicine recipe, has been widely used in UM for a long time [ 21 ].…”