ASMq protects against early burn wound progression in rats by alleviating oxidative stress and secondary mitochondria‑associated apoptosis via the Erk/p90RSK/Bad pathway

Zhou, Hanlei; Fang, Quan; Li, Nan; Yu, Meirong; Chen, Hongming; Guo, Songxue

doi:10.3892/mmr.2021.12029

Cited by 6 publications

(3 citation statements)

References 45 publications

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“…In the laboratory, Zhou et al, using a rat model, discovered, after the application of nanofat to burn wounds not only healed faster due to increased rates of cell proliferation but also formed more new micro vessels due to the upregulation of vascular endothelial growth factor production. 32 Clinically, Rigotti et al demonstrated the histological effects of ASCs on aged facial skin. 18 …”

Section: Discussionmentioning

confidence: 99%

LaMiNa: A Creative Synergistic Approach to Facial Rejuvenation

Claytor

Sheck²,

Jones

et al. 2023

Aesthetic Surgery Journal Open Forum

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Background Treating facial aging with CO2 lasering or microneedling are cornerstones of facial rejuvenation. Skin rejuvenation utilizing thermal and mechanical treatments have historically been considered too injurious to be combined at a single setting. Autologous nanofat has been shown to deliver wound healing properties. We investigated the safety and efficacy of co-terminus CO2 lasering and microneedling to resolve fine lines and rhytids in facial skin with addition of autologous nanofat to aid in recovery. Objectives Combination treatments may result in better results with faster recovery. We investigated the safety and efficacy of co-terminus CO2 lasering and microneedling to resolve fine lines and rhytids in facial skin with addition of autologous nanofat to aid in recovery. Methods Twenty-three patients underwent facial treatment with CO2 lasering followed by microneedling and application of autologous nanofat (LaMiNa). One volunteer patient had tissue biopsies of treatment areas to demonstrate histologic tissue level changes. Results All patients verbally reported no pain (NRS 0/10) following procedure and had rapid recovery within an average of 5 days. Pathology results demonstrated that CO2 and microneedling had persistent epidermal disruption and perineural inflammation at 4 days while the introduction of autologous nanofat at the time of CO2 and microneedling resulted in full recovery of epidermis and resolution of perineural inflammation. Conclusions Triple therapy (LaMiNa) with thermal CO2 remodeling and mechanical microneedling penetration have accelerated and pain free recovery with the addition of autologous nanofat. Histologic analysis reveals that epidermal recovery is accelerated and perineural inflammation is reduced with the addition of autologous nanofat following skin remodeling from combined CO2 and microneedling.

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Section: Discussionmentioning

confidence: 99%

LaMiNa: A Creative Synergistic Approach to Facial Rejuvenation

Claytor

Sheck²,

Jones

et al. 2023

Aesthetic Surgery Journal Open Forum

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“…The unphosphorylated form of Bad, a Bcl‐2 family member, can bind to Bcl‐xL or Bcl‐2 and inhibit their anti‐apoptotic potential, enhancing cytochrome C release and caspase activation (Cook et al, 2017; Danial, 2008; Kheirallah et al, 2013). Several studies have shown that the ERK1/2‐P90RSK‐Bad pathway may protect against apoptosis (Fang et al, 2019; Park et al, 2018; Zhou et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Pretreatment with Notoginsenoside R1 attenuates high‐altitude hypoxia‐induced cardiac injury via activation of the ERK1/2‐P90RSK‐Bad signaling pathway in rats

Zhao

Jia

Shen

et al. 2023

Phytotherapy Research

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High‐altitude cardiac injury (HACI) is one of the common tissue injuries caused by high‐altitude hypoxia that may be life threatening. Notoginsenoside R1 (NG‐R1), a major saponin of Panax notoginseng, exerts anti‐oxidative, anti‐inflammatory, and anti‐apoptosis effects, protecting the myocardium from hypoxic injury. This study aimed to investigate the protective effect and molecular mechanism of NG‐R1 against HACI. We simulated a 6000 m environment for 48 h in a hypobaric chamber to create a HACI rat model. Rats were pretreated with NG‐R1 (50, 100 mg/kg) or dexamethasone (4 mg/kg) for 3 days and then placed in the chamber for 48 h. The effect of NG‐R1 was evaluated by changes in Electrocardiogram parameters, histopathology, cardiac biomarkers, oxidative stress and inflammatory indicators, key protein expression, and immunofluorescence. U0126 was used to verify whether the anti‐apoptotic effect of NG‐R1 was related to the activation of ERK pathway. Pretreatment with NG‐R1 can improve abnormal cardiac electrical conduction and alleviate high‐altitude‐induced tachycardia. Similar to dexamethasone, NG‐R1 can improve pathological damage, reduce the levels of cardiac injury biomarkers, oxidative stress, and inflammatory indicators, and down‐regulate the expression of hypoxia‐related proteins HIF‐1α and VEGF. In addition, NG‐R1 reduced cardiomyocyte apoptosis by down‐regulating the expression of apoptotic proteins Bax, cleaved caspase 3, cleaved caspase 9, and cleaved PARP1 and up‐regulating the expression of anti‐apoptotic protein Bcl‐2 through activating the ERK1/2‐P90RSK‐Bad pathway. In conclusion, NG‐R1 prevented HACI and suppressed apoptosis via activation of the ERK1/2‐P90RSK‐Bad pathway, indicating that NG‐R1 has therapeutic potential to treat HACI.

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“…These re show that cinnamon aqueous extract, acting on the transcription factors NF-KB and 1, has an important anti-cancer effect in vivo [1]. Even if aqueous cinnamon extrac not lead to morphological changes in cells 24 h from exposure, a progressive augme apoptotic cells has been observed [18] and it seems that the apoptosis rate gradual creases depending on the time from cinnamon administration; in fact, in order to v this condition, neoplastic cells of colorectal adenocarcinoma have been treated with natural compound and showed a similar time-related pattern in increasing apoptosis Furthermore, aqueous cinnamon extract proved to be capable of stimulating the ex sion of pro-apoptotic genes such as Bim and Bax [19][20][21][22][23][24][25][26].…”

Section: Inhibition Of Nf-kb and Ap-1mentioning

confidence: 99%

The Anti-Cancer Effect of Cinnamon Aqueous Extract: A Focus on Hematological Malignancies

Caserta

Genovese

Cicero

et al. 2023

Life

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Cinnamon is an evergreen and tropical plant of the family Lauraceae, growing particularly in Sri Lanka, whose aqueous extract has been tested in different studies to evaluate its possible use as an anti-cancer compound. Both in vitro and in vivo experiments seem to confirm that it acts on various cellular pathways, contributing to down-regulating the activity of molecules that stimulate the proliferation and survival of cells such as the transcription factors NF-KB and AP-1, COX-2, dihydrofolate reductase and pro-angiogenic substances such as VEGF, while up-regulating the function of immune cells against tumors, such as cytotoxic CD8+ T cells. In hematological malignancies, aqueous cinnamon extract has been studied in order to understand if it is possible to count on its help, alone or in combination with traditional drugs such as doxorubicin, to treat patients. The aim of our work is to investigate results from in vitro and in vivo studies about the possible anti-cancer effect of aqueous cinnamon extract in hematological malignancies and the different pathways involved in its action. The possibility of using cinnamon extract in clinical practice is discussed; even if its use could appear very interesting, more studies are necessary to clear the real potentiality of this substance in cancer.

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ASMq protects against early burn wound progression in rats by alleviating oxidative stress and secondary mitochondria‑associated apoptosis via the Erk/p90RSK/Bad pathway

Cited by 6 publications

References 45 publications

LaMiNa: A Creative Synergistic Approach to Facial Rejuvenation

LaMiNa: A Creative Synergistic Approach to Facial Rejuvenation

Pretreatment with Notoginsenoside R1 attenuates high‐altitude hypoxia‐induced cardiac injury via activation of the ERK1/2‐P90RSK‐Bad signaling pathway in rats

The Anti-Cancer Effect of Cinnamon Aqueous Extract: A Focus on Hematological Malignancies

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