Differential Inotropic-Chronotropic Action of Carteolol

Chiba, Shigetoshi

doi:10.1254/jjp.27.585

Japanese Journal of Pharmacology

1977

DOI: 10.1254/jjp.27.585

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Differential Inotropic-Chronotropic Action of Carteolol

Shigetoshi Chiba

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1978

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Cited by 9 publications

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“…properties (quinidine-like effect) (5,12,13,43). Table 1 summarizes its pharmacologic profile relative to several other currently available B-blocking drugs.…”

mentioning

confidence: 99%

Carteolol

Sander

Giles

1986

Cardiovascular Drug Reviews

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“…properties (quinidine-like effect) (5,12,13,43). Table 1 summarizes its pharmacologic profile relative to several other currently available B-blocking drugs.…”

mentioning

confidence: 99%

Carteolol

Sander

Giles

1986

Cardiovascular Drug Reviews

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Antihypertensive Effect of Carteolol in Thiazide‐Treated Hypertensive Subjects

Velasquez

Byrne

Hoffmann

1985

The Journal of Clinical Pharma

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The antihypertensive effect of carteolol, a new potent nonselective beta-adrenergic antagonist, was investigated in a double-blind, parallel study of 35 patients with mild-to-moderate, essential hypertension whose blood pressures were not adequately controlled with a diuretic. Patients were randomly assigned to receive placebo, carteolol 5 mg, or carteolol 20 mg once a day in addition to hydrochlorothiazide 50 mg for six weeks. Thirty-four patients completed the study: 11 patients received placebo (group 1), 12 patients received carteolol 5 mg (group 2), and 11 patients received carteolol 20 mg (group 3). After six weeks of treatment, the two groups that received carteolol had significant reductions in systolic (SBP) and diastolic (DBP) blood pressure from baseline in both the supine and standing positions. In group 2, mean SBP decreases for supine and standing positions were 11 +/- 2.1 and 11 +/- 1.9 mm Hg, respectively (P less than .01) and 8 +/- 1.2 and 9 +/- 1.3 mm Hg, respectively, for DBP (P less than .01); whereas in group 3, values were 8 +/- 2.8 and 12 +/- 3.0 mm Hg for SBP, in 5 +/- 1.9 and 9 +/- 3.1 mm Hg, respectively, for DBP (P less than .01). The hypotensive effect was associated with slight but significant decreases in heart rate (P less than .01 in group 2 and P less than .05 in group 3). Reductions in SBP and DBP with the 20-mg dose were not significantly different from those with the 5-mg dose.2+ moderate hypertension.

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Concentration-effect and time-effect relationships of carteolol

Ishizaki¹,

Ohnishi

Sasaki³

et al. 1983

Eur J Clin Pharmacol

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The concentration-beta blocking effect and time-effect relationships of carteolol were examined in eight normal adults given 15 mg i.v. and 20 mg orally on separate occasions. Resting and post-exercise blood pressures and heart rates were assessed before and at various times up to 48 h after each dose. Carteolol, a beta-blocker with some partial agonist activity, produced an insignificant, transient increase in heart rate 2 to 6 h after both doses, and a fall (p less than 0.05) in diastolic blood pressure 4 and 6 h after the intravenous dose and 6 h after the oral dose in the resting supine position, as compared to the corresponding baseline values. All values of the post-exercise heart rate and the double product after each of the doses were significantly (p less than 0.001) below the baseline values for the entire period (48 h) of observation. A significant correlation between the log plasma carteolol concentration (log C) and its beta-blocking effect (E: p less than 0.001, r = 0.508 i.v.; p less than 0.001, r = 0.626, p.o.) was found. The r-values for individuals were higher (0.852 to 0.977, intravenous; 0.817 to 0.981, oral) than for the group as a whole. The slope (m) of the relationship, E = m X log C + r, showed a certain variance within and between individuals.(ABSTRACT TRUNCATED AT 250 WORDS)

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Differential Inotropic-Chronotropic Action of Carteolol

Cited by 9 publications

References 6 publications

Carteolol

Carteolol

Antihypertensive Effect of Carteolol in Thiazide‐Treated Hypertensive Subjects

Concentration-effect and time-effect relationships of carteolol

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