Differential inhibition of proliferation of human squamous cell carcinoma, gliosarcoma and embryonic fibroblast-like lung cells in culture by plant flavonoids

Kandaswami, Chithan; Perkins, Eddie; Drzewiecki, G.; Soloniuk, Donald S.; Middleton, Elliott

doi:10.1097/00001813-199210000-00013

Cited by 67 publications

(28 citation statements)

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“…Flavonoids are polyphenols present in vegetables, fruit, and beverages of plant origin which have antioxidant, antimutagenic, and antiproliferative properties (1)(2)(3)(4)(5). They may thus have a potential protective role in various chronic diseases, including common cancers (6)(7)(8)(9), and explain, at least in part, the well-established associations between high consumption of vegetables and fruit and reduced risk of several neoplasms (10,11).…”

Section: Introductionmentioning

confidence: 99%

Flavonoids and Breast Cancer Risk in Italy

Bosetti

Spertini

Parpinel

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

167

111

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Few epidemiologic studies have investigated the potential relation between flavonoids and breast cancer risk. We have applied recently published data on the composition of foods and beverages in terms of six principal classes of flavonoids (i.e., flavanones, flavan-3-ols, flavonols, flavones, anthocyanidines, and isoflavones) on dietary information collected in a large-case control study of breast cancer conducted in Italy between 1991 and 1994. The study included 2,569 women with incident, histologically confirmed breast cancer, and 2,588 hospital controls. Odds ratios (OR) and 95% confidence intervals were estimated by multiple logistic regression models. After allowance for major confounding factors and energy intake, a reduced risk of breast cancer was found for increasing intake of flavones (OR, 0.81, for the highest versus the lowest quintile; P-trend, 0.02), and flavonols (OR, 0.80; P-trend, 0.06).

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Section: Introductionmentioning

confidence: 99%

Flavonoids and Breast Cancer Risk in Italy

Bosetti

Spertini

Parpinel

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

167

111

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“…Flavonoids constitute a group of interesting polyphenolic compounds with a wide distribution in fruits and vegetables (27,28) and have been shown to exert a wide range of beneficial effects on human health, including protection against cardiovascular diseases and different forms of cancers (18). In the past decade, some flavonoids have been implicated in the modulation of P-gp-type MDR in cancers and shown to inhibit a variety of ATP-binding proteins such as plasma membrane ATPase (24,44), cyclic AMP-dependent protein kinase (25), and protein kinase C (17).…”

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confidence: 99%

Flavonoid Dimers as Bivalent Modulators for Pentamidine and Sodium StiboglucanateResistance in Leishmania

Wong

Chan

Burkett

et al. 2007

Antimicrob Agents Chemother

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Drug resistance by overexpression of ATP-binding cassette (ABC) transporters is an impediment in the treatment of leishmaniasis. Flavonoids are known to reverse multidrug resistance (MDR) in Leishmania and mammalian cancers by inhibiting ABC transporters. Here, we found that synthetic flavonoid dimers with three (compound 9c) or four (compound 9d) ethylene glycol units exhibited a significantly higher reversing activity than other shorter or longer ethylene glycol-ligated dimers, with ϳ3-fold sensitization of pentamidine and sodium stibogluconate (SSG) resistance in Leishmania, respectively. This modulatory effect was dosage dependent and not observed in apigenin monomers with the linker, suggesting that the modulatory effect is due to its bivalent nature. The mechanism of reversal activity was due to increased intracellular accumulation of pentamidine and total antimony in Leishmania. Compared to other MDR modulators such as verapamil, reserpine, quinine, quinacrine, and quinidine, compounds 9c and 9d were the only agents that can reverse SSG resistance. In terms of reversing pentamidine resistance, 9c and 9d have activities comparable to those of reserpine and quinacrine. Modulators 9c and 9d exhibited reversal activity on pentamidine resistance among LeMDR1 ؊/؊ , LeMDR1 ؉/؉ , and LeMDR1-overexpressed mutants, suggesting that these modulators are specific to a non-LeMDR1 pentamidine transporter. The LeMDR1 copy number is inversely related to pentamidine resistance, suggesting that it might be involved in importing pentamidine into the mitochondria. In summary, bivalency could be a useful strategy for the development of more potent ABC transporter modulators and flavonoid dimers represent a promising reversal agent for overcoming pentamidine and SSG resistance in parasite Leishmania.

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“…In conclusion, this study suggests that flavanone intake is inversely associated with esophageal cancer risk and may account, with vitamin C, for the protective effect of fruit, especially citrus fruit, on esophageal cancer. ' 2006 Wiley-Liss, Inc.Key words: flavonoids; squamous cell esophageal cancer; flavanones; case-control study; risk factors Flavonoids are a large group of compounds contained in foods and beverages of plant origin, which cannot be synthesized by humans.1,2 As several flavonoids have antioxidant properties, as well as antimutagenic and antiproliferative properties in vitro, [3][4][5] these compounds have been investigated for possible inverse associations with chronic diseases, including various types of cancer, [6][7][8][9][10][11] and may explain at least in part, the protective effect of vegetable and fruit against cancer.12,13 Over 4,000 different flavonoids have been described, and they have been grouped into 6 classes, i.e. flavanones, flavan-3-ols, flavonols, flavones, anthocyanidines and isoflavones.…”

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confidence: 99%

Flavonoids and risk of squamous cell esophageal cancer

Rossi

Garavello

Talamini

et al. 2007

Intl Journal of Cancer

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The relation between 5 classes of flavonoids (flavanones, flavan-3-ols, flavonols, flavones and anthocyanidines) and esophageal cancer was investigated using data from a case-control study conducted between 1992 and 1997 in 3 areas of northern Italy. The study included 304 cases (275 men, 29 women) with a first diagnosis of squamous-cell carcinoma of the esophagus and 743 controls (593 men, 150 women) with no history of cancer, admitted for acute illnesses, unrelated to tobacco and alcohol consumption, to major hospitals of the areas under surveillance. Dietary habits were investigated using a validated food frequency questionnaire. Odds ratios (ORs) and 95% confidence intervals (CI) were computed after allowance for age, sex, study centre, years of education, alcohol drinking, tobacco smoking, body mass index and energy intake. An inverse association emerged between flavanone intake and esophageal cancer risk (OR 5 0.38 for the highest vs. the lowest quintile, 95% CI 5 0.23-0.66). The inverse relation between flavanones and esophageal cancer tended to be stronger in those who drank 6 drinks/day. In conclusion, this study suggests that flavanone intake is inversely associated with esophageal cancer risk and may account, with vitamin C, for the protective effect of fruit, especially citrus fruit, on esophageal cancer. ' 2006 Wiley-Liss, Inc.Key words: flavonoids; squamous cell esophageal cancer; flavanones; case-control study; risk factors Flavonoids are a large group of compounds contained in foods and beverages of plant origin, which cannot be synthesized by humans.1,2 As several flavonoids have antioxidant properties, as well as antimutagenic and antiproliferative properties in vitro, [3][4][5] these compounds have been investigated for possible inverse associations with chronic diseases, including various types of cancer, [6][7][8][9][10][11] and may explain at least in part, the protective effect of vegetable and fruit against cancer.12,13 Over 4,000 different flavonoids have been described, and they have been grouped into 6 classes, i.e. flavanones, flavan-3-ols, flavonols, flavones, anthocyanidines and isoflavones.14 Until recently, the lack of a comprehensive nutritional database has however hindered a thorough epidemiological investigation of their role in cancer prevention.As concerns esophageal cancer, several studies have reported a protective effect of fruit and vegetables. 15,16 To our knowledge, only 2 studies have investigated the relation between flavonoids and esophageal cancer risk, showing conflicting results. A casecontrol study from Uruguay, 17 including 66 esophageal cancer cases (of unspecified histology), found an inverse association between flavonoids and esophageal cancer risk [odds ratio (OR) 5 0.4 for the highest vs. the lowest tertile, 95% confidence interval, CI, 0.3-0.6]; while another study, conducted in China, 18 on a cohort that had generated 42 esophageal cancer cases (mostly squamous cell carcinomas) reported no association between urinary polyphenol markers deriving from tea...

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Differential inhibition of proliferation of human squamous cell carcinoma, gliosarcoma and embryonic fibroblast-like lung cells in culture by plant flavonoids

Cited by 67 publications

References 0 publications

Flavonoids and Breast Cancer Risk in Italy

Flavonoids and Breast Cancer Risk in Italy

Flavonoid Dimers as Bivalent Modulators for Pentamidine and Sodium StiboglucanateResistance in Leishmania

Flavonoids and risk of squamous cell esophageal cancer

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