Differential identification of Anaplasma in cattle and potential of cattle to serve as reservoirs of Anaplasma capra, an emerging tick-borne zoonotic pathogen

Seo, Min-Goo; Ouh, In-Ohk; Lee, Haeseung; Geraldino, Paul John L.; Rhee, Man Hee; Kwon, Oh-Deog; Kwak, Dongmi

doi:10.1016/j.vetmic.2018.10.008

Cited by 37 publications

(38 citation statements)

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“…H. longicornis is mainly obtained from grasses and herbaceous vegetation, H. flava is frequently obtained from forests, and I. nipponensis is obtained from both habitats across South Korea [17]. All three ticks identified in this study are vectors and hosts for many TBPs and can transmit them to animals and humans in South Korea [6][7][8][9][10][11][12][13].…”

Section: Discussionmentioning

confidence: 84%

“…A. bovis is not considered a zoonotic pathogen, and it could be identified in cattle having subclinical signs, including lymphadenopathy, depression, fever, and abnormal conditions [20]. A. bovis was previously detected in South Korea in ticks (7.5%, 20/266 pools) from Korean water deer [7], in cattle (1.0%, 12/1219) [10], and in H. longicornis ticks (1.0%, 5/506 pools) [6]. Additionally, it has been detected in H. longicornis ticks (26.4%, 77/292) from goats in North Korea [8].…”

Section: Discussionmentioning

confidence: 99%

“…There is a rapidly increasing number of reservoir-adapted pathogens among various species of ticks, which are known or suspected vectors of zoonotic TBPs. Previous studies have investigated the Pathogens 2020, 9, 71 2 of 12 presence of TBPs in South Korea by assessing ticks and cattle, using molecular methods [6][7][8][9][10][11][12][13]. The native Korean goat (NKG, Capra hircus coreanae) is an individual breed of goat primarily raised for natural health supplements and meat in South Korea, and it is known to be an essential natural reservoir host of several TBPs that influence human, wildlife, and domestic animal populations [14,15].…”

Section: Introductionmentioning

confidence: 99%

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Molecular and Phylogenetic Analysis of Tick-Borne Pathogens in Ticks Parasitizing Native Korean Goats (Capra hircus coreanae) in South Korea

2020

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Tick-borne pathogens (TBPs) are considered zoonotic re-emerging pathogens, with ticks playing important roles in their transmission and ecology. Previous studies in South Korea have examined TBPs residing in ticks; however, there is no phylogenetic information on TBPs in ticks parasitizing native Korean goat (NKG; Capra hircus coreanae). The present study assessed the prevalence, risk factors, and co-infectivity of TBPs in ticks parasitizing NKGs. In total, 107 hard ticks, including Haemaphysalis longicornis, Ixodes nipponensis, and Haemaphysalis flava, were obtained from NKGs in South Korea between 2016 and 2019. In 40 tested tick pools, genes for four TBPs, namely Coxiella-like endosymbiont (CLE, 5.0%), Candidatus Rickettsia longicornii (45.0%), Anaplasma bovis (2.5%), and Theileria luwenshuni (5.0%) were detected. Ehrlichia, Bartonella spp., and severe fever with thrombocytopenia syndrome virus were not detected. To our knowledge, this is the first study to report CLE and T. luwenshuni in H. flava ticks in South Korea. Considering the high prevalence of Candidatus R. longicornii in ticks parasitizing NKGs, there is a possibility of its transmission from ticks to animals and humans. NKG ticks might be maintenance hosts for TBPs, and we recommend evaluation of the potential public health threat posed by TBP-infected ticks.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Molecular and Phylogenetic Analysis of Tick-Borne Pathogens in Ticks Parasitizing Native Korean Goats (Capra hircus coreanae) in South Korea

2020

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“…The gltA gene of the Cheongju strain shared a similarity of 99.5% (with two substitutions, A/G at position 456 and T/C at position 533) with gltA sequences KM206274, KJ700628 and MH029895 isolated from a human, goat and tick, respectively [12,23]. Sequences of the Chungbuk strain showed a similarity of 98-99% with KX685885, KX685886 and MF071308 of A. capra from ticks and sheep [13,19]. Both strains clustered with their homologous sequences in the A. capra clade (Fig.…”

Section: Phylogenetic Analysismentioning

confidence: 95%

“…The provisional name Anaplasma capra was assigned after its initial characterization in goats (Capra aegagrus hircus) in China [12]. Later, it was isolated from sheep, goats and cattle in different geographical regions [15][16][17][18][19] as well as from various tick species (Haemaphysalis qinghaiensis, H. longicornis, Ixodes persulcatus) [12,[20][21][22][23]. Infection of A. capra was also reported in six wild animals in China including three takins (Budorcas taxicolor), two Reeves's muntjacs (Muntiacus reevesi) and one forest musk deer (Moschus berezovskii) [24].…”

Section: Introductionmentioning

confidence: 99%

Novel variants of the newly emerged Anaplasma capra from Korean water deer (Hydropotes inermis argyropus) in South Korea

et al. 2019

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Background: Anaplasma spp. are tick-borne Gram-negative obligate intracellular bacteria that infect humans and a wide range of animals. Anaplasma capra has emerged as a human pathogen; however, little is known about the occurrence and genetic identity of this agent in wildlife. The present study aimed to determine the infection rate and genetic profile of this pathogen in wild animals in the Republic of Korea. Methods: A total of 253 blood samples [198 from Korean water deer (Hydropotes inermis argyropus), 53 from raccoon dogs (Nyctereutes procyonoides) and one sample each from a leopard cat (Prionailurus bengalensis) and a roe deer (Capreolus pygargus)] were collected at Chungbuk Wildlife Center during the period 2015-2018. Genomic DNA was extracted from the samples and screened for presence of Anaplasma species by PCR/sequence analysis of 429 bp of the 16S rRNA gene marker. Anaplasma capra-positive isolates were genetically profiled by amplification of a longer fragment of 16S rRNA (rrs) as well as partial sequences of citrate synthase (gltA), heat-shock protein (groEL), major surface protein 2 (msp2) and major surface protein 4 (msp4). Generated sequences of each gene marker were aligned with homologous sequences in the database and phylogenetically analyzed. Results: Anaplasma capra was detected in blood samples derived from Korean water deer, whereas samples from other animal species were negative. The overall infection rate in tested samples was 13.8% (35/253) and in the water deer the rate was 17.8% (35/198), distributed along the study period from 2015 to 2018. Genetic profiling and a phylogenetic analysis based on analyzed gene markers revealed the occurrence of two distinct strains, clustered in a single clade with counterpart sequences of A. capra in the database. Conclusions: Anaplasma capra infection were detected in Korean water deer in the Republic of Korea, providing insight into the role of wildlife as a potential reservoir for animal and human anaplasmosis. However, further work is needed in order to evaluate the role of Korean water deer as a host/reservoir host of A. capra.

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Molecular survey of Anaplasma and Ehrlichia species in livestock ticks from Kassena-Nankana, Ghana; with a first report of Anaplasma capra and Ehrlichia minasensis

et al. 2023

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Differential identification of Anaplasma in cattle and potential of cattle to serve as reservoirs of Anaplasma capra, an emerging tick-borne zoonotic pathogen

Cited by 37 publications

References 35 publications

Molecular and Phylogenetic Analysis of Tick-Borne Pathogens in Ticks Parasitizing Native Korean Goats (Capra hircus coreanae) in South Korea

Molecular and Phylogenetic Analysis of Tick-Borne Pathogens in Ticks Parasitizing Native Korean Goats (Capra hircus coreanae) in South Korea

Novel variants of the newly emerged Anaplasma capra from Korean water deer (Hydropotes inermis argyropus) in South Korea

Molecular survey of Anaplasma and Ehrlichia species in livestock ticks from Kassena-Nankana, Ghana; with a first report of Anaplasma capra and Ehrlichia minasensis

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